Dissociation of E∶T conjugates upon activation of human natural killers by factors acting at the “lethal blow” stage

Abstract

It is demonstrated that in the presence of human recombinant T-interferon and Creactive protein the activity of natural killers increases 9-43%, whereas the number of effector:target cell conjugates formed at the stage of recognizing and binding of target cells decreases 14-80%. There is a weak positive correlation (p =0.35) between the activity of natural killers and the number of effector:target cell conjugates,

Signal splitting as the basis for involvement of natural cytotoxicity system in endogenous biological retranslation

“…--high variability of functional activity of the natural killers (NK) manifested on the cell, organism (sex and age), and population levels [19,21,27]; --wide-range sensitivity of these cells to immunoregulatory peptides of different origin, such as interferons (IFN), interleukins (IL), C-reactive protein, serum components [13,22,[24][25][26];…”