Interleukin-18 Promoter Polymorphisms in Patients With Behçet’s Disease

Lee, Yun Jong; Kang, Seong Wook; Park, Jeong Jin; Bae, Young Deok; Lee, Eun Young; Lee, Eun Bong

doi:10.1016/j.humimm.2006.07.012

Cited by 28 publications

(13 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore the ethnic variation of an allele frequency may partly account for the discrepancy in the results of association studies in various populations [40]. The frequency of rs187238C varies among different ethnic populations (Supplementary Table 3S) as reports for other SNPs [40] and is more than 2 times as high in Caucasians (25.0-27.3%) [10,11,29] as in Asians (10.7-12.0%) [38,[41][42][43]. This allele has a lower promoter activity [10] and is expected to suppress the expression of the IL18 gene and confer protection against HT.…”

Section: Discussionmentioning

confidence: 95%

The IL18 gene and Hashimoto thyroiditis in children

Huang

Ting

et al. 2013

Human Immunology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 95%

The IL18 gene and Hashimoto thyroiditis in children

Huang

Ting

et al. 2013

Human Immunology

View full text Add to dashboard Cite

“…Recently, Musabak and colleagues [23] and Lee and colleagues [24] independently showed the role of another proinflammatory cytokine, IL-18, in the pathogenesis of BD. It was proposed that IL-18 probably directs the immune response in BD toward the T helper 1 type pathway.…”

Section: Discussionmentioning

confidence: 99%

A panel of oxidative stress assays does not provide supplementary diagnostic information in Behcet's disease patients

Akçay

Sağın

Aksu

et al. 2012

Journal of Inflammation

View full text Add to dashboard Cite

BackgroundRecent findings suggest a role of oxidative stress in the pathogenesis of Behcet's disease (BD), but the utility of oxidative stress-associated assays in offering diagnostic information or in the monitoring of disease activity is largely unassessed.Objective and methodsWe aimed to measure oxidative and inflammatory markers, along with the markers of reactive nitrogen species, S-nitrosothiols and 3-nitrotyrosine, in BD patients (n = 100) and healthy volunteers (n = 50). These markers were evaluated in regard to their role in the pathogenesis of BD as well as their relation to clinical presentation, disease activity and duration.ResultsMedian values for erythrocyte sedimentation rate (ESR), C-reactive protein, leukocyte count, and IL-18 levels, as well as myeloperoxidase (MPO) activity, were statistically higher in the patient group compared to controls. Some inflammation markers (ESR, neutrophil and leukocyte counts) were statistically higher (p < 0.05) in the active period. In contrast, oxidative stress-associated measures (erythrocyte lipid peroxidation, antioxidant enzymes and measures of serum antioxidant capacity), revealed no statistically significant differences between the median values in BD patients versus healthy control subjects (p > 0.05 in all statistical comparisons), nor was there any difference in median levels of these oxidative stress markers in active disease versus disease remission. S-nitrosothiols and 3-nitrotyrosine were undetectable in BD plasma.ConclusionsThe application of oxidative stress-associated measures to BD blood samples offered no supplemental diagnostic or disease activity information to that provided by standard laboratory measures of inflammation. S-nitrosothiols and 3-nitrotyrosine appeared not to be markers for active BD; thus the search for biochemical markers that will indicate the active period should be continued with larger studies.

show abstract

“…This is contrary to the findings of Keskin, et al , who reported that allele “C” is the minor allele and BD-associated allele in rs1946518 from studies in an independent Turkish sample 10 . A genetic association of rs1946518 albeit with allele “C” was also reported in Korean patients with BD 11 . This association was not found in another independent Korean sample set 12 .…”

Section: To the Editormentioning

confidence: 62%