Interleukin-17 mediates lung injury by promoting neutrophil accumulation during the development of contagious caprine pleuropneumonia

Beware of Mycoplasma Anti-immunoglobulin Strategies

“…Through its action as a signaling molecule, IL-8 fosters the recruitment of neutrophils to the lung epithelium. These findings are convergent with the well-established neutrophil accumulation in lungs during infections by respiratory mycoplasmas ( 85 – 89 ). Neutrophils counteract the infection through phagocytosis and/or the release of neutrophil extracellular traps (NETs) ( 90 ).…”

Dynamic Changes of NCR− Type 3 Innate Lymphoid Cells and Their Role in Mice with Bronchopulmonary Dysplasia

“…IL-17, a key cytokine for accumulation and activation of neutrophils, can recruit neutrophils by inducing chemokines Cxcl1 and Cxxl9 [ 35 ]. It can regulate the migration of lung neutrophils, promote the generation of oxygen free radicals and extracellular traps in mouse neutrophils, and ultimately aggravate lung injury [ 36 , 37 ]. Besides, IL-17 can also induce the production of various inflammatory cytokines, such as tumor necrosis factor (TNF), IL-6, and GM-CSF [ 38 ], suggesting that IL-17 plays an important role in inflammation.…”

Bacterial Diseases Affecting Sheep and Goats

“…CCPP is one of the most contagious and virulent goat diseases. Ailment due to Mycoplasma capricolum capripneumoniae is febrile and respiratory in nature, marked by labored breathing and exasperate coughing (Ma et al 2020). Difficulty in breathing would cause patients to adopt a distinctive posture whereby neck is extended and legs are spread wide.…”

“…Stressful conditions and exposure to carrier animals facilitate spread of disease in the herd. Post-mortem findings often reveal straw-colored phlegm and pea-sized nodules in the thorax (Ma et al 2020). In most cases massive hepatization of infected lungs is seen along with mononuclear infiltration on histopathological slides.…”

“…While diagnosis could be confirmed by culturing fluid samples from lungs. Quinolones, Tetracyclines, and Macrolides could prove efficacious against M. capricolum capripneumoniae but animals may remain carriers for this disease (Ma et al 2020).…”