Interleukin-11 Drives Early Lung Inflammation during Mycobacterium tuberculosis Infection in Genetically Susceptible Mice

Kapina, Marina A.; Shepelkova, Galina; Avdeenko, Vadim G.; Guseva, A. N.; Kondratieva, Tatiana; Evstifeev, Vladimir; Apt, Alexander S.

doi:10.1371/journal.pone.0021878

Cited by 24 publications

(15 citation statements)

References 31 publications

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“…In a mouse model of tuberculosis, IL-11 was increased during infection, and IL-11 inhibition decreased early neutrophil influx and TB disease severity [37, 42]. Here we also demonstrate that neutralization of IL-11 decreases neutrophil accumulation, but this outcome was not associated with changes in bacterial clearance.…”

Section: Discussion/conclusionsupporting

confidence: 50%

“…Several studies suggest that systemic IL-11 plays an important role in regulating tissue injury and inflammation during lung infections [10, 11, 17, 37]. Given that many IL-6 family cytokines are induced in murine models of bacterial pneumonia, and modulation of these cytokines results in disparate effects on host defense and resilience to lung injury [20–22], we sought to determine functional contributions of IL-11 in response to lung infection.…”

Section: Discussion/conclusionmentioning

confidence: 99%

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Roles of interleukin-11 during acute bacterial pneumonia

et al. 2019

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Interleukin-11 (IL-11) is an interleukin-6 (IL-6) family cytokine shown to play a protective role in acute inflammatory settings including systemic infection. In this study we addressed the role of IL-11 in acute bacterial pneumonia using a mouse model of E. coli pneumonia. Compared with other related cytokines, IL-11 protein was maintained at high levels in the lung at baseline, with only mild alterations in whole lung and BALF levels during acute infection. The primary source of IL-11 in the lung was the epithelium, but steady state production was not dependent on the inflammatory transcription factor nuclear factor kappa B in cells of either myeloid or epithelial lineage. Blockade of IL-11 with neutralizing antibodies resulted in a mild but significant decrease in neutrophil recruitment and increase in pulmonary edema during pneumonia, without detectable alterations in bacterial clearance. Exogenous IL-11 administration, however, had no effect at baseline or during infection. Overall, we conclude that maintenance of lung IL-11 concentrations may influence acute pulmonary inflammation during infection, albeit modestly.

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Section: Discussion/conclusionsupporting

confidence: 50%

Section: Discussion/conclusionmentioning

confidence: 99%

Roles of interleukin-11 during acute bacterial pneumonia

et al. 2019

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“…In several clinical and experimental studies, IL-11 exhibited anti-inflammatory activity (27,28). IL-11 mediates anti-inflammatory activities during chemotherapy-induced oral mucositis (29), acute intestinal ischemia (30) and in Clostridium difficile toxin A-associated intestinal toxicity (31).…”

Section: Correlation Between Il-11 Level and Clinicopathological Featmentioning

confidence: 99%

Interleukin-11, an interleukin-6-like cytokine, is a promising predictor for bladder cancer prognosis

Wu¹,

Tao

Ding

et al. 2012

Molecular Medicine Reports

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Abstract. Numerous studies have suggested that interleukin 11 (IL-11) has roles in human gastric, prostate and bone cancer and endometrial carcinoma. Hence, we evaluated the expression of IL-11 in bladder cancer and the correlation of IL-11 levels and clinico pathological features. The expression of IL-11 in primary human bladder cell culture, human bladder cancer cell lines, transitional cell carcinoma (TCC) and non-cancerous bladder tissues (NATs) were analyzed by western blotting. Enzyme-linked immunosorbent assay (ELISA) for urinary IL-11 was performed to compare the IL-11 levels in healthy subjects and subjects diagnosed with bladder cancer. Our study suggested that the expression of IL-11 in human bladder cancer cell lines and TCC was downregulated compared with primary human bladder cell culture and matched NATs. We also demonstrated reduced urinary levels of IL-11 in subjects with bladder cancer compared with healthy subjects. Furthermore, we revealed that the levels of IL-11 were associated with tumor grade and stage. The results suggested that reduced levels of IL-11 may play an important role in the carcinogenesis and progression of TCC. They also indicated that IL-11 may be a promising predictor for prognosis of TCC.

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“…To test this hypothesis, cytokines and chemokines previously reported to be involved in the host immune response and/or pathogenesis of TB were selected for evaluation. These included cytokines shaping host immunity (IL-1␤, IL-4, IL-6, IL-9, IL-10, IL-12, IL-13, IL-17A, IFN-␥, IL- (such as IL-1␣, IL-6, TNF-␣, IL-8, IL-11, and IL-1␤) (13,15,16).…”

mentioning

confidence: 99%