Interleukin‐10 responses from acute exercise in healthy subjects: A systematic review

Cabral-Santos, Carolina; Lima, Edson Alves de; Fernandes, Isabela Maia da Cruz; Pinto, Rafael Zambelli; Neto, José Cesar Rosa; Bishop, Nicolette C.; Lira, Fábio Santos

doi:10.1002/jcp.27920

Cited by 65 publications

(49 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies suggested that the effect of aerobic exercise on the cytokines' increase is different from the effect of strength/resistance exercise, with the latter being less evident (Santos et al, 2019). This is in line with our evidence.…”

Section: Implications For Practicesupporting

confidence: 93%

“…Regardless, levels of IL-10 tend to peak during recovery time from exercise, with the magnitude of the increase being related to the active muscle mass and exercise intensity. Overall, the duration of the exercise was the most important factor determining the magnitude of the exercise-induced increase of plasma IL-10, as recently reviewed by Santos et al (2019). This increase in IL-10 could be related to the prevention of potential deleterious chronic low-grade inflammation and tissue damage.…”

Section: Exercise-induced Effects On Cytokinesmentioning

confidence: 95%

See 1 more Smart Citation

Inflammatory Effects of High and Moderate Intensity Exercise—A Systematic Review

et al. 2020

View full text Add to dashboard Cite

Background: Exercise leads to a robust inflammatory response mainly characterized by the mobilization of leukocytes and an increase in circulating inflammatory mediators produced by immune cells and directly from the active muscle tissue. Both positive and negative effects on immune function and susceptibility to minor illness have been observed following different training protocols. While engaging in moderate activity may enhance immune function above sedentary levels, excessive amounts of prolonged, high-intensity exercise may impair immune function. Thus, the aim of the present review was to clarify the inflammatory effects in response to different exercise intensities. Methods: Search was performed on PubMed and was completed on July 31st, 2017. The studies were eligible if they met the predefined inclusion criteria: a) observational or interventional studies, b) conducted in healthy adults (18-65 years), c) written in Portuguese, English or Spanish, d) including moderate and/or intense exercise. Eighteen articles were included. The specific components that were examined included circulating blood levels of cytokines, leukocytes, creatine kinase (CK) and C-reactive protein (CRP). The methodological quality of the included studies was assessed. Results: Most of the intervention studies showed changes in the assessed biomarkers, although these changes were not consistent. White blood cells (WBC) had an increase immediately after intensive exercise (> 64% VO 2max), without alteration after moderate exercise (46-64% VO 2max). The results suggested an elevation of the pro-inflammatory cytokines, namely IL-6, followed by an elevation of IL-10 that were more evident after intense exercise bouts. CRP increased both after intense and moderate exercise, with peak increases up to 28 h. CK increased only after intensive and long exercising. Conclusion: In summary, intense long exercise can lead, in general, to higher levels of inflammatory mediators, and thus might increase the risk of injury and chronic inflammation. In contrast, moderate exercise or vigorous exercise with appropriate resting periods can achieve maximum benefit.

show abstract

Section: Implications For Practicesupporting

confidence: 93%

Section: Exercise-induced Effects On Cytokinesmentioning

confidence: 95%

Inflammatory Effects of High and Moderate Intensity Exercise—A Systematic Review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Thus, the exercise appears to be a low‐cost alternative to improve obesity‐related inflammatory disorders by increasing concentrations of IL‐10 and IL‐33. Confirming this, a recent systematic review highlighted the role of exercise for the increase of systemic IL‐10 levels . Here, a 1 week HIIT was able to increase the peripheral frequency of Treg and mTreg cells in obese individuals.…”

Section: Discussionmentioning

confidence: 99%

Cardiorespiratory fitness modulates the proportions of monocytes and T helper subsets in lean and obese men

Dorneles

Silva

Boeira

et al. 2019

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

Funding informationWe are grateful to the Brazilian agencies Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) -Finance Code 001, CAPES (CAPES-PNPD -23038007200/11-08) and Conselho Nacional de Desenvolvimento Cientifico e Tecnológico (CNPq) for financial support. PDL, AP, and PRTR also thank CNPq for fellowships.This study investigated the peripheral frequency of monocytes, CD4 + T cell subsets and the systemic levels of cytokines in lean and obese men with different levels of cardiorespiratory fitness (CRF). Mononuclear cells were obtained from 45 lean and 45 obese men who were assigned into six groups according to their body mass index and CRF (low, moderate, or high VO 2Peak ) to analyze the frequency of monocyte subsets and subpopulations of CD4 + T cells (Treg cells, CD4 + CD25 high CD127 low ; mTeff, CD4 + CD25-CD39+; mTreg, CD4 + CD25+CD39+). The systemic levels of interleukin (IL)-6, IL-10, IL-17a, IL-33, leptin, and tumor necrosis factor-alpha (TNF-α) were also evaluated. Seven sedentary obese men performed one week of high-intensity interval training (HIIT, 3 sessions/week), and blood samples were collected before and 24 hours after the last session for phenotypic analysis of T cells and monocytes. Obese individuals presented an inflammatory profile characterized by lower frequencies of Treg and mTreg cells and higher proportions of proinflammatory monocytes. However, higher CRF status increased the frequencies of Treg cells and mTreg cells and decreased the percentage of CD4 + mTeff cells and intermediate and non-classical monocytes in the peripheral blood from lean and obese men. Systemic lower levels of proinflammatory (IL-6 and TNF-) cytokines and higher concentrations of IL-10 and IL-33 were observed in moderate and higher CRF in all subjects. HIIT increased the proportions of circulating mTreg and Treg cells in sedentary obese individuals. The immunoregulatory role of CRF contributes to the maintenance of low levels of inflammatory mediators. K E Y W O R D S CD39, CD73, exercise, inflammation, monocyte subsets, obesity, T cells, Treg cells, VO 2 peak 1756 | DORNELES Et aL. SUPPORTING INFORMATIONAdditional supporting information may be found online in the Supporting Information section at the end of the article. How to cite this article: Dorneles GP, da Silva I, Boeira MC, et al. Cardiorespiratory fitness modulates the proportions of monocytes and T helper subsets in lean and obese men. Scand J Med Sci Sports.

show abstract

“…They may be useful markers for assessing the effects of physical exercise on the immune system. For instance, cytokine IL-6 augments anti-inflammatory cytokines (such as IL-10), which exhibit potent anti-inflammatory properties when produced during exercise [18], blocking a possible persistent inflammatory state while stimulating the production of interleukin-1 receptor antagonist (IL-1ra) [19].…”

Section: Discussionmentioning

confidence: 99%

Immune and Hormonal Response to High-intensity Exercise During Orienteering

et al. 2019

View full text Add to dashboard Cite

Orienteering is an endurance sport that combines physical and cognitive activity, during which the athlete must complete a course with several points distributed over unknown terrain in the shortest possible time. A number of studies have investigated the body’s physiological adaptations to the stress caused during competition, but not the immunological changes. To that end, the present study evaluated the immunological, physiological and pathological responses in athletes performing high-intensity physical exercise during an orienteering race. The 30 athletes tested belonged to the elite orienteering category and participated in the regional championship. Cortisol levels were determined before and after the competition to assess stress response, as were the cytokines IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ and IL-17 to evaluate the immune response. Cortisol levels increased after the competition, indicating a stress condition. IFN-γ, IL-6 and IL-10 levels also rose post competition. The results indicate that orienteers are exposed to high stress levels, and that this condition affects their immune and endocrine systems, triggering a predominantly anti-inflammatory response, likely an athlete’s mechanism of adaptation to the stress imposed by high-intensity physical exercise.

show abstract

Interleukin‐10 responses from acute exercise in healthy subjects: A systematic review

Cited by 65 publications

References 33 publications

Inflammatory Effects of High and Moderate Intensity Exercise—A Systematic Review

Inflammatory Effects of High and Moderate Intensity Exercise—A Systematic Review

Cardiorespiratory fitness modulates the proportions of monocytes and T helper subsets in lean and obese men

Immune and Hormonal Response to High-intensity Exercise During Orienteering

Contact Info

Product

Resources

About