Interleukin-10 Production During and After Upper Abdominal Surgery

Kato, Masaru; Honda, Izumi; Suzuki, Hitoshi; Morikawa, Mamoru; Matsukawa, Shu; Hashimoto, Yuichi

doi:10.1016/s0952-8180(97)00264-x

Cited by 55 publications

(25 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, of the 17 cytokines examined, KC, GM-CSF, IL-6, IL-10, G-CSF, IL-5, IL-17, IFN-␥, and MIP-1␣ increased after sham operation compared with baseline. Cytokine production after surgical procedures is a well-described phenomenon in patients that has been linked to postsurgical multisystem organ failure and mortality (27,28). Abdominal surgery, in particular, is associated with increased serum IL-6, G-CSF (27), and IL-10 (28).…”

Section: Discussionmentioning

confidence: 99%

Acute Renal Failure after Bilateral Nephrectomy Is Associated with Cytokine-Mediated Pulmonary Injury

Hoke¹,

Douglas²,

Klein³

et al. 2007

Journal of the American Society of Nephrology

274

275

View full text Add to dashboard Cite

Clinical studies demonstrate that acute renal failure (ARF) is associated with increased mortality, which may be due to pulmonary complications. ARF may affect the lung via increased renal production or impaired clearance of mediators of lung injury, such as proinflammatory cytokines. Bilateral nephrectomy is a method to examine directly the deleterious systemic effects of absent renal clearance in ARF without the confounding effects that are associated with ischemia-reperfusion injury (e.g., ischemic ARF) or systemic toxicity (e.g., cisplatin-induced ARF). This study contrasts the effects of ischemic ARF and bilateral nephrectomy on serum cytokines and lung injury. It demonstrates that the acute absence of kidney function after both ischemic ARF and bilateral nephrectomy is associated with an increase in multiple serum cytokines, including IL-6 and IL-1␤, and that the cytokine profiles were distinct. Lung injury after ischemic ARF and bilateral nephrectomy was similar and was characterized by pulmonary vascular congestion and neutrophil infiltration. For investigation of the role of proinflammatory cytokines in pulmonary injury after ARF, the anti-inflammatory cytokine IL-10 was administered before bilateral nephrectomy. IL-10 treatment improved pulmonary architecture and was associated with a reduction in inflammatory markers, including bronchoalveolar lavage fluid total protein, pulmonary myeloperoxidase activity (a biochemical marker of neutrophils), and the chemokine macrophage inflammatory protein 2. These data demonstrate for the first time that the acute absence of kidney function results in pulmonary injury independent of renal ischemia and highlight the critical role of the kidney in the maintenance of serum cytokine balance and pulmonary homeostasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Acute Renal Failure after Bilateral Nephrectomy Is Associated with Cytokine-Mediated Pulmonary Injury

Hoke¹,

Douglas²,

Klein³

et al. 2007

Journal of the American Society of Nephrology

274

275

View full text Add to dashboard Cite

show abstract

“…At T6, T7 and T8 the serum levels after open nephrectomy were slightly higher than in patients undergoing laparoscopic unilateral or bilateral nephrectomy. Kato et al [33]found IL–10 to become elevated during and after upper abdominal surgery. However, a comparison to laparoscopy was not performed in this study.…”

Section: Discussionmentioning

confidence: 99%

Why Is Urological Laparoscopy Minimally Invasive?

Fornara

Doehn

Seyfarth³

et al. 2000

European Urology

113

View full text Add to dashboard Cite

“…It has generally been believed that pro-inflammatory cytokines rather than anti-inflammatory cytokines are the central cause of these diseases. For example, it is observed that the concentration of pro-inflammatory cytokine is elevated in patients with lethal septic shock, systemic inflammatory response syndrome, cachexia, transplant rejection and various inflammatory diseases [3,4,26,27]. In animal models, the administration of pro-inflammatory cytokine inhibitors (anti-TNF-a monoclonal antibody, anti-IL-8 monoclonal antibody, recombinant IL-1RA and so on) result in inhibition of both acute and chronic inflammatory responses [28][29][30].…”

Section: Discussionmentioning

confidence: 99%