Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia

Belisário, André Rolim; Sales, Rahyssa Rodrigues; Toledo, Nayara Evelin; Velloso-Rodrigues, Cibele; Silva, Célia Maria; Viana, Marcos Borato

doi:10.1016/j.bjhh.2016.09.017

Cited by 5 publications

(1 citation statement)

References 34 publications

(42 reference statements)

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“…The titles and abstracts of these studies were filtrated according to inclusion criteria. Finally, seventeen full text articles were eligible for this meta-analysis [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] (Fig. 1).…”

Section: Retrieved Studiesmentioning

confidence: 99%

Serum level of IL-10 and IL-10-1082G/A polymorphism are associated with the risk of ischemic stroke: A meta-analysis

Rui¹,

Sha

Wen

et al. 2020

Preprint

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BACKGROUND Stroke is one of the leading causes of disability and mortality among adults worldwide. The aim of the study was to confirm the relationship of serum interleukin-10 (IL-10) and its gene polymorphism with the risk of ischemic stroke (IS). METHODS PubMed and China Wanfang database were systematically searched up to September 2, 2019. Studies illustrating on the association between serum IL-10 or IL-10-1082G/A, IL-10-819C/T, IL-10- 592C/A polymorphisms and IS susceptibility were included in this study. Newcastle–Ottawa scale was used to assess the study quality. RevMan 5.3 was used for statistical analysis. RESULTS: Seventeen case-control studies were included in this meta-analysis which provides 3754 patients with IS and 5064 controls. Combined analysis indicated that patients with IS had lower serum level of IL-10 (Mean difference [MD]: -4.25; 95% confidence interval [CI]: -6.14 to -2.36, p<0.0001). An association was identified between IL-10-1082G/A polymorphism and the risk of IS, but no association was found between polymorphism of IL-10-819C/T or IL-10- 592C/A and the risk of IS when all ethnic groups were considered together. For IL-10-1082G/A polymorphism, individuals with AA-genotype might have an increased risk of IS among Chinese Han population while no such correlation was observed in other ethnic group. CONCLUSION This meta-analysis suggested that low serum level of IL-10 and IL-10-1082G/A polymorphism may be associated with the risk of IS. More clinical studies should be conducted to confirm the relationship between serum IL-10 level and the risk of IS in all ethnic groups.

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Section: Retrieved Studiesmentioning

confidence: 99%

Serum level of IL-10 and IL-10-1082G/A polymorphism are associated with the risk of ischemic stroke: A meta-analysis

Rui¹,

Sha

Wen

et al. 2020

Preprint

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Genetic Variation and Sickle Cell Disease Severity

Kirkham,

Estepp,

Weiss

et al. 2023

JAMA Netw Open

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ImportanceSickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are influenced by additional genetic factors. Despite decades of research, the genetics of SCD remain poorly understood.ObjectiveTo assess all reported genetic modifiers of SCD, evaluate the design of associated studies, and provide guidelines for future analyses according to modern genetic study recommendations.Data SourcesPubMed, Web of Science, and Scopus were searched through May 16, 2023, identifying 5290 publications.Study SelectionAt least 2 reviewers identified 571 original, peer-reviewed English-language publications reporting genetic modifiers of human SCD phenotypes, wherein the outcome was not treatment response, and the comparison was not between SCD subtypes or including healthy controls.Data Extraction and SynthesisData relevant to all genetic modifiers of SCD were extracted, evaluated, and presented following STREGA and PRISMA guidelines. Weighted z score meta-analyses and pathway analyses were conducted.Main Outcomes and MeasuresOutcomes were aggregated into 25 categories, grouped as acute complications, chronic conditions, hematologic parameters or biomarkers, and general or mixed measures of SCD severity.ResultsThe 571 included studies reported on 29 670 unique individuals (50% ≤ 18 years of age) from 43 countries. Of the 17 757 extracted results (4890 significant) in 1552 genes, 3675 results met the study criteria for meta-analysis: reported phenotype and genotype, association size and direction, variability measure, sample size, and statistical test. Only 173 results for 62 associations could be cross-study combined. The remaining associations could not be aggregated because they were only reported once or methods (eg, study design, reporting practice) and genotype or phenotype definitions were insufficiently harmonized. Gene variants regulating fetal hemoglobin and α-thalassemia (important markers for SCD severity) were frequently identified: 19 single-nucleotide variants in BCL11A, HBS1L-MYB, and HBG2 were significantly associated with fetal hemoglobin (absolute value of Z = 4.00 to 20.66; P = 8.63 × 10−95 to 6.19 × 10−5), and α-thalassemia deletions were significantly associated with increased hemoglobin level and reduced risk of albuminuria, abnormal transcranial Doppler velocity, and stroke (absolute value of Z = 3.43 to 5.16; P = 2.42 × 10−7 to 6.00 × 10−4). However, other associations remain unconfirmed. Pathway analyses of significant genes highlighted the importance of cellular adhesion, inflammation, oxidative and toxic stress, and blood vessel regulation in SCD (23 of the top 25 Gene Ontology pathways involve these processes) and suggested future research areas.Conclusions and RelevanceThe findings of this comprehensive systematic review and meta-analysis of all published genetic modifiers of SCD indicated that implementation of standardized phenotypes, statistical methods, and reporting practices should accelerate discovery and validation of genetic modifiers and development of clinically actionable genetic profiles.

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A meta-analysis on associations of IL-6 and IL-10 polymorphisms with susceptibility to ischemic stroke

Chen

Yang

2019

Journal of Neuroimmunology

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Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia

Cited by 5 publications

References 34 publications

Serum level of IL-10 and IL-10-1082G/A polymorphism are associated with the risk of ischemic stroke: A meta-analysis

Serum level of IL-10 and IL-10-1082G/A polymorphism are associated with the risk of ischemic stroke: A meta-analysis

Genetic Variation and Sickle Cell Disease Severity

A meta-analysis on associations of IL-6 and IL-10 polymorphisms with susceptibility to ischemic stroke

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