A meta-analysis on associations of IL-6 and IL-10 polymorphisms with susceptibility to ischemic stroke

Chen, Miao; Yang, Yongmei

doi:10.1016/j.jneuroim.2019.577004

Cited by 8 publications

(7 citation statements)

References 26 publications

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“…A sample size calculation was performed using the freely available G*Power version 3.1.9.2 application power analysis ( 33 ). To achieve a power of 95% at an α of 0.05, the sample size was calculated based on the previous reports ( 14 , 15 ). The estimated sample sizes were 367 and 420 subjects for the IL-6 and TNF-α genotypes, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…Inflammatory cytokines and chemokines have been used as predictors of stroke incidence and outcomes ( 12 , 13 ). Thus, the genetic variation of inflammatory cytokine genes has become a critical issue in research relating to the predictive risk factors of IS occurrence ( 14 , 15 ), as well as its severity and outcome ( 16 ), and this provides potential therapeutic options for the treatment of inflammatory diseases ( 17 , 18 ).…”

Section: Introductionmentioning

confidence: 99%

“…Single-nucleotide polymorphisms (SNPs) are the most commonly studied genetic variations for IS susceptibility ( 24 ), and functional SNPs located in a gene's promoter region regulate that gene's transcriptional expression ( 25 , 26 ). A meta-analysis revealed that the IL-6 -174G/C polymorphism was significantly associated with IS risk in Asian populations in both dominant and recessive inheritance models ( 14 ). However, other studies reported that the IL-6 -174G/C polymorphism was not associated with the risk of IS in North Indian ( 16 , 27 ) and Chinese populations ( 28 ).…”

Section: Introductionmentioning

confidence: 99%

“…However, there remains considerable controversy surrounding the two SNPs, IL-6 -174G/C and TNF-α -308G/A, which are located in the promoter region of the gene ( 14-16 , 32 ). These may be predictive risk factors of IS development and modify the gene's transcriptional activities, thereby contributing to changes in the gene's expression levels.…”

Section: Introductionmentioning

confidence: 99%

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Promoter polymorphism of TNF‑α (rs1800629) is associated with ischemic stroke susceptibility in a southern Thai population

et al. 2021

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Stroke represents the leading cause of disability and mortality amongst the elderly worldwide. Multiple risk factors, including both genetic and non-genetic components, as well as their interactions, are proposed as etiological factors involved in the development of ischemic stroke (IS). Promoter polymorphisms of the IL-6-174G/C (rs1800795) and TNF-α-308G/A (rs1800629) genes have been considered as predictive risk factors of IS; however, these have not yet been evaluated in a Thai population. The aims of this study were to investigate the association of IL-6-174G/C and TNF-α-308G/A polymorphisms with IS. Genomic DNA from 200 patients with IS and 200 controls were genotyped for IL-6-174G/C and TNF-α-308G/A polymorphisms using TaqMan™ SNP genotyping and quantitative PCR-high resolution melting analysis, respectively. It was found that the TNF-α-308 A allele was significantly associated with an increased risk of IS development compared with the G allele [odds ratio (OR)=2.044; 95% CI=1.154-3.620; P=0.014]. Moreover, the IS risk was significantly higher in the presence of TNF-α-308 GA or AA genotypes compared with that in the presence of GG genotypes with a dominant inheritance (OR=1.971; 95% CI=1.080-3.599; P=0.027). However, there was no association between IL-6-174G/C and the risk of IS development. The interaction study demonstrated that IL-6-174 GG and TNF-α-308 GG genotypes enhanced IS susceptibility when combined with hypertension, hyperlipidemia and alcohol consumption. Hypertensive and hyperlipidemic subjects with the TNF-α-308 GA and AA genotypes were more likely to develop IS compared with those who did not have these two conditions and had the GG genotype. In a matched study design (1:1), the IL-6-174 GC genotype was associated with higher IL-6 levels in the control group. Collectively, the present results highlight the utility of the TNF-α-308G/A polymorphism as a predictive genetic risk factor for development of IS.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Promoter polymorphism of TNF‑α (rs1800629) is associated with ischemic stroke susceptibility in a southern Thai population

et al. 2021

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“…Based on similarities in structure and receptor subunits, the IL-10 family comprises six members, including IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26 [32][33][34]. As an antiinflammatory cytokine, the neuroprotective effect of IL-10 on cerebral I/R injury has been identified in numerous studies [35,36]. In addition, IL-19 administration also reduced ischemia-induced brain infarct and neurological deficits in mice after experimental ischemic stroke, indicating that IL-19 Mediators of Inflammation is a novel therapeutic target for cerebral I/R injury [37].…”

Section: Discussionmentioning

confidence: 99%

Interleukin-22 Plays a Protective Role by Regulating the JAK2-STAT3 Pathway to Improve Inflammation, Oxidative Stress, and Neuronal Apoptosis following Cerebral Ischemia-Reperfusion Injury

Dong

Huang

et al. 2021

Mediators of Inflammation

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The interleukins (ILs) are a pluripotent cytokine family that have been reported to regulate ischemic stroke and cerebral ischemia/reperfusion (I/R) injury. IL-22 is a member of the IL-10 superfamily and plays important roles in tissue injury and repair. However, the effects of IL-22 on ischemic stroke and cerebral I/R injury remain unclear. In the current study, we provided direct evidence that IL-22 treatment decreased infarct size, neurological deficits, and brain water content in mice subjected to cerebral I/R injury. IL-22 treatment remarkably reduced the expression of inflammatory cytokines, including IL-1β, monocyte chemotactic protein- (MCP-) 1, and tumor necrosis factor- (TNF-) α, both in serum and the ischemic cerebral cortex. In addition, IL-22 treatment also decreased oxidative stress and neuronal apoptosis in mice after cerebral I/R injury. Moreover, IL-22 treatment significantly increased Janus tyrosine kinase (JAK) 2 and signal transducer and activator of transcription (STAT) 3 phosphorylation levels in mice and PC12 cells, and STAT3 knockdown abolished the IL-22-mediated neuroprotective function. These findings suggest that IL-22 might be exploited as a potential therapeutic agent for ischemic stroke and cerebral I/R injury.

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Electro-acupuncture treatment ameliorates intestinal inflammatory injury in cerebral ischemia–reperfusion rats via regulating the balance of Treg / γδ T cells

et al. 2023

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A meta-analysis on associations of IL-6 and IL-10 polymorphisms with susceptibility to ischemic stroke

Cited by 8 publications

References 26 publications

Promoter polymorphism of TNF‑α (rs1800629) is associated with ischemic stroke susceptibility in a southern Thai population

Promoter polymorphism of TNF‑α (rs1800629) is associated with ischemic stroke susceptibility in a southern Thai population

Interleukin-22 Plays a Protective Role by Regulating the JAK2-STAT3 Pathway to Improve Inflammation, Oxidative Stress, and Neuronal Apoptosis following Cerebral Ischemia-Reperfusion Injury

Electro-acupuncture treatment ameliorates intestinal inflammatory injury in cerebral ischemia–reperfusion rats via regulating the balance of Treg / γδ T cells

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