Interleukin-10 gene -592C&gt;A polymorphism and susceptibility to gastric cancer

Qi, Ming; Liu, D.M.; Pan, Lishou; Lin, Yunfeng

doi:10.4238/2014.october.31.10

Cited by 14 publications

(12 citation statements)

References 25 publications

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“…IL-10 rs1800896 polymorphism G allele has been shown to cause higher IL-10 production [10], which may further lead to carcinogenesis. Some studies have illustrated that the IL-10 rs1800896 polymorphism was correlated with enhanced risk of nasopharyngeal carcinoma [25] and gastric cancer [26], diabetic nephropathy [27], and non-Hodgkin's lymphoma [28]. However, non significant correlation between the polymorphism and polycystic ovary syndrome [29], cervical cancer [30], periodontal diseases [31] has been revealed.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages

et al. 2017

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BackgroundThe association of interleukin-10 rs1800896 polymorphism with head and neck cancer risk and its clinical stages has been investigated by many published studies, but the results remain inconsistent. Therefore, we conducted this meta-analysis for further investigation.ResultsSix case-control studies involving 1,781 head and neck cancer patients and 1,978 controls were yielded. The results indicated an association between rs1800896 polymorphism and increased head and neck risk [odds ratio (95%confidence interval) for G vs. A, GA vs. AA, GG vs. AA, GA+GG vs. AA, and GG vs. AA + GA were 1.63 (1.30–2.04), 3.17 (2.11–4.76), 1.63 (1.17–2.26), 1.73 (1.25–2.39), and 2.73 (1.82–4.09), respectively]. The subgroup analyses all obtained similar results with overall populations. The results of clinical stages yielded a non-significant association. No publication bias was detected.Materials and MethodsThe PubMed and Chinese National Knowledge Infrastructure databases were searched up to December 27, 2016. Two authors independently selected studies, extracted and analyzed the data using the RevMan 5 software. Either a fixed effect or a random effect model was used to estimate pooled odds ratio and its 95% confidence intervals.ConclusionsWe concluded that interleukin-10 rs1800896 polymorphism was significantly associated with head and neck cancer risk but not with the clinical stages thereof.

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Section: Discussionmentioning

confidence: 99%

Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages

et al. 2017

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“…One such gene possibly associated with HCC is IL-10. Previous studies have reported associations between polymorphisms of this gene and the development of cancers, as well as several other diseases, including acute pancreatitis, coronary artery disease, and colorectal, gastric, oral, lung, esophageal, and breast cancers (Miteva et al, 2014;Qi et al, 2014;Hsu et al, 2015;Jia et al, 2015;Kumar et al, 2015;Vinod et al, 2015;Xu and Liu, 2015;Yang and Fa, 2015;Zhang et al, 2015b). For instance, Miteva et al (2014) reported that the IL-10 -1082A/G polymorphism has a significant impact on the development of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, Miteva et al (2014) reported that the IL-10 -1082A/G polymorphism has a significant impact on the development of colorectal cancer. Qi et al (2014) conducted a meta-analysis of 12 studies, finding that the -592G/A variant correlates with increased risk of gastric cancer among Asians, while Hsu et al (2015) reported that Taiwanese carriers of the -819T/C CT genotype have a 3.32-fold increased risk of oral cancer. Moreover, Zhang et al (2015b) observed that the IL- Table 3.…”

Section: Discussionmentioning

confidence: 99%

Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma

Liu

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms of IL-10 (-592G/A, -819T/ C, and -1082A/C) in the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The study included 173 HBV-related HCC patients and 182 healthy controls. A polymerase chain reaction-restriction fragment length polymorphism assay was applied to assess the sequence variants of interest. Compared with control subjects, HCC patients were more likely to be older (t = 1.94, P = 0.03), have a family history of cancer (chi square = 17.86, P < 0.001), and exhibit higher alanine transaminase (t = 13.32, P < 0.001) and aspartate transaminase (t = 12.63, P < 0.001) levels. Using unconditional logistic regression analyses, we found that the GG genotype of -592G/A was associated with increased risk of HCC [odds ratio (OR) = 2.20, 95% confidence interval (CI) = 1.12-4.38], compared to the AA genotype. Under a dominant model, the AG+GG genotype correlated with HBV-related HCC susceptibility compared to the AA genotype, with an OR (95%CI) of 1.56 (1.02-2.48). Moreover, a recessive model showed the GG genotype to be associated with elevated risk of HCC compared to the AA+AG genotype (OR = 1.85, 95%CI = 1.01-3.47). However, no significant association between the -819T/C and -1082A/C variants and development of HBV-related HCC was observed under codominant, dominant, and recessive models. We conclude that the IL-10 -592G/A polymorphism does play a role in susceptibility to HBV-related HCC under codominant, dominant, and recessive models.

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“…This cytokine downregulates the production of pro-inflammatory cytokines by inhibition of Th 1 lymphocytes and stimulation of B, as well as Th 2, lymphocytes and thus downregulates the inflammatory response[212,213]. Since 2003 researchers have consistently reported associations between IL-10-592 A/C SNP and susceptibility to gastric cancer but with mixed or conflicting results[217]. A meta-analysis performed by Ni et al[218] indicated that in Asian populations the carriers of IL-10 -1082 GG-plus-GA genotypes are more susceptible to all types of gastric cancer.…”

Section: Inflammation Driven Malignancy Riskmentioning

confidence: 99%

Host pathogen interactions in Helicobacter pylori related gastric cancer

Chmiela¹,

Karwowska²,

Gonciarz³

et al. 2017

WJG

140

129

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Helicobacter pylori (H. pylori), discovered in 1982, is a microaerophilic, spiral-shaped gram-negative bacterium that is able to colonize the human stomach. Nearly half of the world's population is infected by this pathogen. Its ability to induce gastritis, peptic ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma has been confirmed. The susceptibility of an individual to these clinical outcomes is multifactorial and depends on H. pylori virulence, environmental factors, the genetic susceptibility of the host and the reactivity of the host immune system. Despite the host immune response, H. pylori infection can be difficult to eradicate. H. pylori is categorized as a group I carcinogen since this bacterium is responsible for the highest rate of cancer-related deaths worldwide. Early detection of cancer can be lifesaving. The 5-year survival rate for gastric cancer patients diagnosed in the early stages is nearly 90%. Gastric cancer is asymptomatic in the early stages but always progresses over time and begins to cause symptoms when untreated. In 97% of stomach cancer cases, cancer cells metastasize to other organs. H. pylori infection is responsible for nearly 60% of the intestinal-type gastric cancer cases but also influences the development of diffuse gastric cancer. The host genetic susceptibility depends on polymorphisms of genes involved in H. pylori-related inflammation and the cytokine response of gastric epithelial and immune cells. H. pylori strains differ in their ability to induce a deleterious inflammatory response. H. pylori-driven cytokines accelerate the inflammatory response and promote malignancy. Chronic H. pylori infection induces genetic instability in gastric epithelial cells and affects the DNA damage repair systems. Therefore, H. pylori infection should always be considered a pro-cancerous factor.

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Interleukin-10 gene -592C>A polymorphism and susceptibility to gastric cancer

Cited by 14 publications

References 25 publications

Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages

Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages

Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma

Host pathogen interactions in Helicobacter pylori related gastric cancer

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