Interleukin-10 family cytokines pathway: genetic variants and psoriasis

Галимова, Е. С.; Rätsep, Ranno; Traks, Tanel; Kingo, Külli; Escott‐Price, Valentina; Kõks, Sulev

doi:10.1111/bjd.15363

Cited by 19 publications

(8 citation statements)

References 63 publications

(162 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In African Americans, the rs1400986 and rs1518108 polymorphisms were associated with chronic hepatitis B infection [16]. Galimova et al, [30] analyzed 48 polymorphisms in 377 patients with psoriasis and 403 healthy controls and reported that the rs1400986 T allele was associated with decreased risk of psoriasis and that the combination of IL10 rs1554286 and IL20 rs1518108 was associated also with a reduced risk of presenting this disease. In these studies, were only compared the three different genotypes in each polymorphism, they did not use an analysis considering the inheritance models like in our study.…”

Section: Discussionmentioning

confidence: 99%

Common Variants in IL-20 Gene are Associated with Subclinical Atherosclerosis, Cardiovascular Risk Factors and IL-20 Levels in the Cohort of the Genetics of Atherosclerotic Disease (GEA) Mexican Study

et al. 2020

View full text Add to dashboard Cite

Inflammation has been involved in the development of atherosclerosis, type 2 diabetes mellitus, insulin resistance, and obesity. Interleukin 20 is a pro-inflammatory cytokine encoded by a polymorphic gene located in chromosome 1. The aim of the study was to evaluate the association of two IL-20 polymorphisms (rs1400986 and rs1518108) with subclinical atherosclerosis (SA), cardiovascular risk factors and IL-20 levels in a cohort of Mexican individuals. The polymorphisms were determined in 274 individuals with SA and 672 controls. Under different models, rs1400986 (OR = 0.51, Pcodominant1 = 0.0001; OR = 0.36, Pcodominant2 = 0.014; OR = 0.49, Pdominant = 0.0001 and OR = 0.55, Padditive = 0.0001) and rs1518108 (OR = 0.62, Pcodominant2 = 0.048 and OR = 0.79, Padditive = 0.048) were associated with a lower risk of SA. These polymorphisms were associated with cardiovascular risk factors in individuals with SA and controls. Controls with the rs1400986 TT genotype presented high levels of IL-20 (p = 0.031). In individuals with the rs1400986 CC genotype, we observed a negative correlation between IL-20 levels and total abdominal tissue (TAT), visceral abdominal tissue (VAT) and subcutaneous abdominal tissue (SAT). Our results indicate that the IL-20 rs1400986 and rs1518108 polymorphisms were associated with decreased risk of developing SA and with some cardiovascular risk factors in individuals with SA and healthy controls. Negative correlation between BMI and VAT/SAT ratio in individuals with rs1400986 CC genotype and among IL-20 levels and TAT, VAT and SAT was observed.

show abstract

Section: Discussionmentioning

confidence: 99%

Common Variants in IL-20 Gene are Associated with Subclinical Atherosclerosis, Cardiovascular Risk Factors and IL-20 Levels in the Cohort of the Genetics of Atherosclerotic Disease (GEA) Mexican Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Attenuated expression of Mda-7/IL-24 was found in various kinds of carcinomas, such as colon cancer, breast cancer, melanoma and acute myeloid leukaemia [4,16,17]. The decreased expression of Mda-7/IL-24 was thought to be associated with numerous tumour biological characteristics, such as growth, metastasis, recurrence and chemotherapy resistance [4,[18][19][20]. Our previous studies have shown that transfection of endogenous Mda-7/IL-24 induced mature differentiation of Raji and Daudi lymphoma cells, which was Figure 3.…”

Section: Discussionmentioning

confidence: 99%

Low expression of Mda-7/IL-24 and high expression of C-myb in tumour tissues are predictors of poor prognosis for Burkitt lymphoma patients

Zhao

Yang

et al. 2018

Hematology

View full text Add to dashboard Cite

show abstract

“…Attenuated expression of Mda-7/IL-24 was found in acute myeloid leukemia and Burkitt lymphoma cells ( 3 , 4 , 15 ). The decreased expression of Mda-7/IL-24 was thought to be associated with numerous tumor biological characteristics, such as differentiation blockage, malignant proliferation, invasion and chemotherapy resistance ( 4 , 16 – 18 ). Our previous studies have shown that transfection of endogenous Mda-7/IL-24 induced terminal differentiation of Burkitt lymphoma cells, which was characterized by growth inhibition, morphological and cell surface antigens changes and decreased expression of malignant markers ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

The clinical significance of Mda‑7/IL‑24 and C‑myb expression in tumor tissues of patients with diffuse large B cell lymphoma

Zhao

Yang

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma in adults. Mda-7/IL-24 had been identified as a differentiation inducer of B phenotype lymphoma cells. Previous studies have revealed that knockdown of C-myb also leads to the terminal differentiation of B cell lymphoma. The aim of the present study was to investigate the association between the expression of Mda-7/IL-24 and C-myb, and their prognostic significance for DLBCL patients. The tumor tissues were collected from 72 cases of DLBCL patients and detected with reverse transcription-quantitative polymerase chain reaction, western blotting and immunohistochemistry assays. The results showed that, the expression of Mda-7/IL-24 mRNA and protein was lower while the expression of C-myb was higher in DLBCL tissues, compared with the specimens of normal lymph node tissues. Furthermore, C-myb expression was negatively correlated with Mda-7/IL-24 expression at mRNA and protein levels in DLBCL tissues. The expression of Mda-7/IL-24 and C-myb in DLBCL tissues was associated with some clinicopathological parameters such as clinical stage, infiltration in bone marrow, Ki67 expression level in the tumor tissues and overall survival rates. These results indicated that low expression of Mda-7/IL-24, along with high expression of C-myb, are predictor for poor prognosis of DLBCL patients, suggesting that Mda-7/IL-24 and C-myb may be potential targets for clinical treatment of DLBCL.

show abstract

Interleukin-10 family cytokines pathway: genetic variants and psoriasis

Cited by 19 publications

References 63 publications

Common Variants in IL-20 Gene are Associated with Subclinical Atherosclerosis, Cardiovascular Risk Factors and IL-20 Levels in the Cohort of the Genetics of Atherosclerotic Disease (GEA) Mexican Study

Common Variants in IL-20 Gene are Associated with Subclinical Atherosclerosis, Cardiovascular Risk Factors and IL-20 Levels in the Cohort of the Genetics of Atherosclerotic Disease (GEA) Mexican Study

Low expression of Mda-7/IL-24 and high expression of C-myb in tumour tissues are predictors of poor prognosis for Burkitt lymphoma patients

The clinical significance of Mda‑7/IL‑24 and C‑myb expression in tumor tissues of patients with diffuse large B cell lymphoma

Contact Info

Product

Resources

About