Interleukin-10: A Pleiotropic Regulator in Pregnancy

Cheng, Shi-Bin; Sharma, Surendra

doi:10.1111/aji.12329

Cited by 134 publications

(93 citation statements)

References 140 publications

(181 reference statements)

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“…Notably, data from animal studies suggest that NS1 activates immunological cascades in monocytes and macrophages leading to the pathologies observed in SD (Chen et al, 2015;Modhiran et al, 2015). In addition to its immunosuppressive roles, IL-10 has recently been reported as a protective mediator against plasma leakage and vascular dysfunction (Cheng & Sharma, 2015). IL-10 is secreted by a variety of cell types including CD4 + and CD8 + T cells, B cells, macrophages, monocytes, eosinophils and mast cells (O'Garra & Vieira, 2007).…”

Section: Discussionmentioning

confidence: 99%

Markers of dengue severity: a systematic review of cytokines and chemokines

Lee

Leong

Wilder‐Smith

2016

Journal of General Virology

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The prognosis of dengue remains a challenge in the early, objective triage of patients with dengue fever of differing severity. Circulating immuno-modulating proteins have brought new possibilities as prognostic markers of severe dengue (SD). This systematic review is devoted to understanding the potential utility of blood-based cytokines and chemokines as prognostication markers of SD based on the current literature. PubMed and Embase were searched. Of 794 candidate articles, 685 abstracts were screened against our exclusion/inclusion criteria and 25 (3.6 %) studies met the quality assessments. A total of 18 studies were retrospective observational and 2 were prospective cohort studies. Elevated IL-10, up to day 7 of fever onset, stood out as a candidate prognostic marker for SD using the 1997 and 2009 World Health Organization (WHO) case definitions. IFNg was another potential prognostic marker of SD (1997 WHO case definition), but its levels varied between studies. Significant heterogeneity in methodologies and patient cohorts prevent ready application of IL-10 and IFNg as prognostic markers to other dengue populations. Our results suggest that the current non-randomized studies are delivering inconsistent messages and higher-quality studies, with consistent methodologies and validation in independent patient cohorts, are needed to delineate confounding variables. Major gaps identified were full accounting and transparency of sampling days, dengue virus type, infection status and age group.

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Section: Discussionmentioning

confidence: 99%

Markers of dengue severity: a systematic review of cytokines and chemokines

Lee

Leong

Wilder‐Smith

2016

Journal of General Virology

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“…Pregnancy is a unique physiological process that involves intricate interplay of inflammatory and anti-inflammatory milieu, hormonal changes, and cellular and molecular events at the maternal-fetal interface (1) . Pre-eclampsia (PE) is a pregnancy-specific disorder (2) characterized by new onset of maternal hypertension and proteinuria after 20 weeks of gestation in a previously normotensive woman (3) .…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 99%

Maternal Oxidant-Antioxidant Homeostasis During Normotensive and Preeclamptic Pregnancy.

MD¹,

MD²,

MD³

2018

IJAR

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Objectives: To evaluate changes in oxidant milieu in normotensive pregnant women (No PE) and those who developed pre-eclampsia (PE) and to define a relation between these changes and PE development. Patients & Methods: All pregnant women gave three blood samples at 12 th week (S1) gestational age, start of 3 rd trimester (S2) and 48-hr postpartum (S3) for spectrophotometeric estimation of serum levels of malondialdehyde (MDA) and uric acid (UA), and activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and catalase activity. Control group included a similar number of non-pregnant women. Blood pressures were estimated at 1 st visit and monthly for diagnosis of PE. Results: 65 pregnant women developed PE; 54 had mild and 11 had severe PE; while 19 women developed early and 46 late PE. Sample S1 levels showed non-significant differences between all study participants. S2 serum MDA levels were significantly higher in pregnant women than their S1 and control levels and in PE versus No PE women. S2 serum UA levels were significantly higher in PE women than their S1, control and corresponding levels in No PE women. S2 serum SOD and GPx activity was significantly lower in PE women than their S1, control and corresponding measures in No PE women. Serum GR and catalase activities were significantly lower in S2 samples of pregnant women than their S1 and control activities with significantly lower activity in No PE women. S3 serum levels of MDA and UA were decreased and activities of antioxidant enzymes were adjusted in S3 sample than in S2 sample, but with significant difference between PE and No PE women. Statistical analysis defined serum MDA at ≥13.2±0.128 µmole/L and GPx activity at ≥450 U/L as risk cutoff point for PE development. Conclusion: Pregnancy is stressful condition associated with activation of oxidative stress (OS) and overproduction of oxidative products and disturbed activity of antioxidant enzymes. Exaggerated OS compromises placental functions and induces development of hypertensive manifestations. Elevated serum MDA and GPx enzyme

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“…Intrauterine actions of angiogenesis, immunity, and neuroendocrine regulation are juxtaposed to mechanisms of fetal growth and protection. The interleukin-10 (IL-10) is a key cytokine that plays a vital role in the maintenance of maternal-fetal tolerance by its pleiotropic activities [6,7]. IL-10 exerts profound effects not only on linking immunity and angiogenesis, but also on suppressing endoplasmic reticulum (ER) stress [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Association of interleukin-10 gene promoter polymorphisms with recurrent pregnancy loss: a meta-analysis

Gong

Zhang

et al. 2016

J Assist Reprod Genet

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Purpose It has been reported single-nucleotide polymorphisms (SNPs) of the IL-10 promoter might be associated with the susceptibility to recurrent pregnancy loss (RPL). Owing to the inconclusive results, we conducted a meta-analysis to systematically summarize and clarify the association between the IL-10 promoter SNPs and RPL risk. Methods A systematic search of studies on the association of the three SNPs with RPL was conducted in PubMed and Embase. Odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were used to pool the effect size. Result Eleven case-control studies on rs1800896, seven studies on rs1800871, and eight studies on rs1800872 were included. A significant association was identified between IL-10 rs1800896 with RPL risk (G versus A: OR = 1.21, 95 % CI 1.09-1.35). No evidence of association was found between rs1800871 and RPL when restricted to those studies in Hardy-Weinberg equilibrium in controls (T versus C: OR = 1.25, 95 % CI 0.76-2.06). No statistical association was demonstrated between rs1800872 and RPL (C versus A: OR = 1.08, 95 % CI 0.83-1.42). Conclusions IL-10 rs1800896 significantly increases the risk of RPL, while rs1800872 is not correlated with RPL risk. No significant association is demonstrated between rs1800871 and RPL risk but this requires further investigation.

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Interleukin-10: A Pleiotropic Regulator in Pregnancy

Cited by 134 publications

References 140 publications

Markers of dengue severity: a systematic review of cytokines and chemokines

Markers of dengue severity: a systematic review of cytokines and chemokines

Maternal Oxidant-Antioxidant Homeostasis During Normotensive and Preeclamptic Pregnancy.

Association of interleukin-10 gene promoter polymorphisms with recurrent pregnancy loss: a meta-analysis

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