Interleukin-1 receptor antagonist in refractory haemochromatosis-related arthritis of the hands

Latourte, Augustin; Frazier, Aline; Brière, Claire; Ea, Hang‐Korng; Richette, Pascal

doi:10.1136/annrheumdis-2012-202738

Cited by 14 publications

(6 citation statements)

References 9 publications

(6 reference statements)

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“…LOGIFER database was declared at the CNIL authority (National Committee for Informatics and Freedom). The study was authorized by the ethics committee of Rennes (number [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. All patients gave informed written consent.…”

Section: Discussionmentioning

confidence: 99%

Worse Outcomes of Patients With HFE Hemochromatosis With Persistent Increases in Transferrin Saturation During Maintenance Therapy

Bardou-Jacquet

Lainé

Guggenbuhl

et al. 2017

Clinical Gastroenterology and Hepatology

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Section: Discussionmentioning

confidence: 99%

Worse Outcomes of Patients With HFE Hemochromatosis With Persistent Increases in Transferrin Saturation During Maintenance Therapy

Bardou-Jacquet

Lainé

Guggenbuhl

et al. 2017

Clinical Gastroenterology and Hepatology

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“…38 Therapeutic efficacy of IL-1RA is demonstrated in hand osteoarthritis 39 and in 2 cases suffering from another form of ironinduced arthropathy in case of hemochromatosis. 40 Opposing IL-1 was most effective when performed within 8 hours after blood exposure, but benefit was still achieved when performed until 24 hours after exposure to blood. This is in line with the observation that IL-1 production in blood-cartilage coculture is detected within 24 hours and prevented by addition of IL-4 and IL-10 within 4 to 8 hours.…”

Section: 28mentioning

confidence: 97%

IL-1β, in contrast to TNFα, is pivotal in blood-induced cartilage damage and is a potential target for therapy

Vulpen

Schutgens²,

Coeleveld

et al. 2015

Blood

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“…A genetic association between IL1RN and joint pain is suggested,93 and therapeutic efficacy of an IL-1 receptor antagonist is described in two patients with HH-related hand arthritis 94…”

Section: Preclinical Studies On the Effects Of Iron Versus Blood On Tmentioning

confidence: 99%

The detrimental effects of iron on the joint: a comparison between haemochromatosis and haemophilia

et al. 2015

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Joint damage due to (recurrent) joint bleeding in haemophilia causes major morbidity. Although the exact pathogenesis has not been fully elucidated, a central role for iron is hypothesised. Likewise, in hereditary haemochromatosis joint destruction is caused by iron overload. A comparison between these types of arthropathy could provide more insight in the influence of iron in inducing joint damage. A literature review was performed to compare both disorders with respect to their clinical and histological characteristics, and preclinical studies on the influence of iron on different joint components were reviewed. Similarities in the features of arthropathy in haemochromatosis and haemophilia are cartilage degeneration, subchondral bone changes with osteophyte and cyst formation, and osteoporosis. In both disorders synovial inflammation and proliferation are seen, although this is much more explicit in haemophilia. Other substantial differences are the age at onset, the occurrence of chondrocalcinosis radiographically and calcium pyrophosphate dihydrate deposition disease in haemochromatosis, and a rapid progression with joint deformity and neovascularisation in haemophilia. Preclinical studies demonstrate detrimental effects of iron to all components of the joint, resulting in synovial inflammation and hyperplasia, chondrocyte death, and impaired osteoblast function. These effects, particularly the synovial changes, are aggravated in the presence of a pro-inflammatory signal, which is prominent in haemophilic arthropathy and minimal in haemochromatosis. Additional research is needed to further specify the role of iron as a specific target in treating these types of arthropathy.

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Interleukin-1 receptor antagonist in refractory haemochromatosis-related arthritis of the hands

Cited by 14 publications

References 9 publications

Worse Outcomes of Patients With HFE Hemochromatosis With Persistent Increases in Transferrin Saturation During Maintenance Therapy

Worse Outcomes of Patients With HFE Hemochromatosis With Persistent Increases in Transferrin Saturation During Maintenance Therapy

IL-1β, in contrast to TNFα, is pivotal in blood-induced cartilage damage and is a potential target for therapy

The detrimental effects of iron on the joint: a comparison between haemochromatosis and haemophilia

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