Interleukin 1 receptor antagonist (IL-1ra) levels in patients with burns

Endo, S; Inada, Katsuya; Baba, Naomichi; Kasai, Tatsuya; Yamada, Yoshiki; Kondo, Mitsuhiro; Kikuchi, Masato; Suzuki, Tomoyuki; Taniguchi, Shotaro; Yoshida, Masao

doi:10.1097/00024382-199409001-00020

Cited by 11 publications

(17 citation statements)

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“…Significantly elevated levels of soluble TNF-a receptors, IL-1 receptor antagonist and IL-10 observed in our patients at the initial stage compared with healthy controls may indicate additional anti-inflammatory mechanisms involved in the course of SIRS during burn injuries (Table 2). Similarly, increased serum levels of IL-10, IL-1 ra and soluble TNF-a receptors in patients with systemic thermal injuries have been previously reported [5,10,11,14].…”

Section: Discussionsupporting

confidence: 59%

“…Recently, a relationship between serum concentrations of soluble TNF-a receptors in patients and further disease development (or death) has been found [10]. Moreover, there have been some correlations between IL-1 ra levels and the surface and depth of burns [11]. Determination of IL-6 or IL-10 levels has been demonstrated to have a prognostic significance in sepsis and death incidence related to SIRS [13,[23][24][25].…”

Section: Discussionmentioning

confidence: 99%

“…To verify this hypothesis we stratified our children into patients with SIRS and poor outcome (hypovolaemic shock) and those with a good outcome and afterwards the analysis by means of the Mann-Whitney test was performed (P < 0.05 for all indices tested). Likewise, the other authors considered IL-1 ra, IL-10 or the ratios of IL-6 to IL-10 and IL-10 to TNF-a to be strong candidates for predicting clinical outcome in SIRS patients [2,11,24,25]. Furthermore, Yamada et al provided evidence that soluble receptors for TNF-a (TNFR I, TNFR II) closely reflected the severity of the burns in both the acute post-burn period and the subsequent follow-up period [10].…”

Section: Discussionmentioning

confidence: 99%

“…IL-4, IL-13, IL-10 that inhibit proinflammatory cytokine production) and in release of circulating soluble receptors or receptor antagonists. Numerous studies have reported the presence of cytokine inhibitors for tumour necrosis factor-a (TNF-a), interleukin (IL)-1, IL-6 as well as anti-inflammatory cytokines in patients with a systemic inflammatory process or severe injury [2,4,[10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Evaluation of Proinflammatory Cytokine Inhibitors (sTNFR I, sTNFR II, IL‐1 ra), Anti‐inflammatory Cytokines (IL‐10, IL‐13) and Activation of Neutrophils after Burn‐induced Inflammation

et al. 2008

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The study was aimed at evaluating the involvement of sTNFR I, sTNFR II, IL‐1 ra, IL‐10, IL‐13 and reactive oxygen species (ROS) in systemic inflammatory response syndrome (SIRS) development in severely burned children and at assessing the prognostic value of the immunological markers studied. The study comprised 37 patients (17 burned children and 20 controls). Serum levels of the markers determined by means of ELISA and respiratory burst of neutrophils as well as p55 and p75 tumour necrosis factor‐α (TNF‐α) receptor expression using flow cytometry were evaluated twice. The burned children presented significantly higher levels of IL‐10 and cytokine inhibitors within the first 6–24 h after injury compared with controls (P < 0.05). The decreased oxygen metabolism of neutrophils and increased TNF‐α receptor expression were found on admission. Moreover, a significant decrease in initially high sTNFR I, sTNFR II, IL‐1 ra, IL‐10, IL‐13 concentrations (P < 0.05) and reduced expression of TNF‐α receptors (P < 0.05) were observed after burn therapy, whereas ROS generation evidently augmented (P < 0.05). Four of our children who developed hypovolaemic shock revealed a significantly lower ROS generation and higher concentrations of soluble TNF‐α receptors and IL‐1 ra together with IL‐10, IL‐13 compared with children with good outcome (P < 0.05). Our results revealed the involvement of both ROS, soluble TNF‐α receptors and IL‐1 ra in the development of SIRS in burned children; their monitoring allows for an assessment of the systemic inflammatory reaction activity. The neutrophil BURSTTEST and IL‐1 ra might have been clinically helpful markers of SIRS prognosis.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical Evaluation of Proinflammatory Cytokine Inhibitors (sTNFR I, sTNFR II, IL‐1 ra), Anti‐inflammatory Cytokines (IL‐10, IL‐13) and Activation of Neutrophils after Burn‐induced Inflammation

et al. 2008

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“…Tamakuma et al have suggested that sivelestat may function by reducing inflammatory reactions in the injured lung (29). Several studies have reported the relationships between the severity of sepsis, trauma, and burns with SIRS (31). SIRS is considered to be induced by hypercytokinemia, and the longer its duration, the likelier it is to progress to multiple organ dysfunction (1,32).…”

Section: Discussionmentioning

confidence: 99%

Effects of sivelestat on bronchial inflammatory responses after esophagectomy

Yamaguchi

Sugasawa²,

Takeuchi³

et al. 2011

Int J Mol Med

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Abstract. Post-operative pulmonary complications such as systemic inflammatory response syndrome (SIRS), acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are strongly associated with morbidity and mortality after esophagectomy. Post-operative administration of sivelestat sodium hydrate (sivelestat), a selective inhibitor of neutrophil elastase (NE), has been shown to improve the post-operative clinical course after esophagectomy. This study aimed to evaluate the effect of prophylactic administration of sivelestat on bronchial inflammatory responses. We randomized 24 patients into two groups. One group received 0.2 mg/kg/h sivelestat from the induction of anesthesia to post-operative day 1 (sivelestat group) and the other group received the same amount of physiological saline (control group). Bronchial alveolar epithelial lining fluid (ELF) samples were obtained from both groups at the induction of anesthesia and at the end of surgery. The serum and ELF levels of interleukin (IL)-6 and IL-8 were measured by enzyme-linked immunosorbent assay, and NE activity was spectrophotometrically determined using the same samples. Although IL-6 levels in the ELF significantly increased at the end of surgery compared with the pre-operative levels in both groups, the IL-8 levels and NE activity did not significantly increase at the end of the surgery compared to the corresponding pre-operative values in the sivelestat group. Moreover, IL-8 levels and NE activity in the ELF were significantly reduced at the end of surgery in the sivelestat group compared with corresponding values in the control group. The durations of ALI and ARDS were apparently shorter in the sivelestat group and the duration of SIRS was significantly shorter in the sivelestat group compared to the control group. We demonstrated that prophylactic use of sivelestat mitigated bronchial inflammation by suppressing NE activity and IL-8 levels in the ELF and shortened the duration of SIRS after transthoracic esophagectomy.

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A novel human ex vivo skin model to study early local responses to burn injuries

Hofmann

Fink

Eberl

et al. 2021

Sci Rep

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Burn injuries initiate numerous processes such as heat shock response, inflammation and tissue regeneration. Reliable burn models are needed to elucidate the exact sequence of local events to be able to better predict when local inflammation triggers systemic inflammatory processes. In contrast to other ex vivo skin culture approaches, we used fresh abdominal skin explants to introduce contact burn injuries. Histological and ultrastructural analyses confirmed a partial-thickness burn pathology. Gene expression patterns and cytokine production profiles of key mediators of the local inflammation, heat shock response, and tissue regeneration were analyzed for 24 h after burn injury. We found significantly increased expression of factors involved in tissue regeneration and inflammation soon after burn injury. To investigate purely inflammation-mediated reactions we injected lipopolysaccharide into the dermis. In comparison to burn injury, lipopolysaccharide injection initiated an inflammatory response while expression patterns of heat shock and tissue regeneration genes were unaffected for the duration of the experiment. This novel ex vivo human skin model is suitable to study the local, early responses to skin injuries such as burns while maintaining an intact overall tissue structure and it gives valuable insights into local mechanisms at the very beginning of the wound healing process after burn injuries.

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Interleukin 1 receptor antagonist (IL-1ra) levels in patients with burns

Cited by 11 publications

References 0 publications

Clinical Evaluation of Proinflammatory Cytokine Inhibitors (sTNFR I, sTNFR II, IL‐1 ra), Anti‐inflammatory Cytokines (IL‐10, IL‐13) and Activation of Neutrophils after Burn‐induced Inflammation

Clinical Evaluation of Proinflammatory Cytokine Inhibitors (sTNFR I, sTNFR II, IL‐1 ra), Anti‐inflammatory Cytokines (IL‐10, IL‐13) and Activation of Neutrophils after Burn‐induced Inflammation

Effects of sivelestat on bronchial inflammatory responses after esophagectomy

A novel human ex vivo skin model to study early local responses to burn injuries

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