Interleukin‐1 receptor antagonist gene polymorphism in japanese patients with systemic lupus erythematosus

Suzuki, Hiroshi; Matsui, Yoshiki; Kashiwagi, Hirokazu

doi:10.1002/art.1780400227

Cited by 35 publications

(24 citation statements)

References 6 publications

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“…This variation may probably have a functional importance because the repeated sequence contains possible binding sites for the transcription factors [23]. Association between the IL-1Ra VNTRs and SLE has also been investigated, both with a positive association [18,24] and a negative association [25,26] as the result.…”

Section: Il-1 Receptor Antagonistmentioning

confidence: 99%

Cytokine Polymorphisms in Systemic Lupus Erythematosus and Sjögren's Syndrome

et al. 2001

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Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) are defined genetically as complex diseases where multiple genes are involved in their pathogenesis. Among the genes of interest are those coding for the cytokines, molecules involved in immunoregulation that have been shown to play important roles in these diseases. Whether abnormalities in cytokine production are owing to genetic polymorphisms within the genes themselves is a matter of intensive study. The finding of functional polymorphisms within cytokine genes and their potential association with disease will open new avenues in their treatment.

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Section: Il-1 Receptor Antagonistmentioning

confidence: 99%

Cytokine Polymorphisms in Systemic Lupus Erythematosus and Sjögren's Syndrome

et al. 2001

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“…This molecule is particularly polymorphic and a significant increase of a null allele has been reported in SLE patients (271), especially those with photosensitivity (272). A correlation with CCLE has also been published in abstract form (273).…”

mentioning

confidence: 99%

The pathophysiology of photosensitivity in lupus erythematosus

Orteu

Sontheimer

Dutz

2001

Photoderm Photoimm Photomed

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“…Competition of sTNF-R with TNF-R on the surface of cells and binding of IL-1Ra to IL-1 receptors on the surface of cells result in interference with TNF activities [22,35] and IL-1 activities [19,20], respectively. The elevation of sTNF-R and IL-1Ra in plasma/serum and biological fluids reflecting a variety of inflammatory disorders has been shown in several diseases [24][25][26][27][28]. In addition, protective and inhibitory effects of sTNF-R and IL-1Ra against several inflammatory diseases have been shown [17,18,[29][30][31].…”

Section: Discussionmentioning

confidence: 99%

“…The elevation of these cytokine inhibitors in serum/plasma and biological fluids in several diseases [24][25][26][27][28], and the inhibitory and protective effects of these cytokine inhibitors against IL-1-and TNF--mediated diseases, have been demonstrated [17,18,[29][30][31]. Although up-regulation of TNF-and IL-1 in bronchial asthma has been demonstrated, serum sTNF-R and IL-1Ra levels have not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

Elevation of serum soluble tumour necrosis factor (TNF) receptor and IL-1 receptor antagonist levels in bronchial asthma

Yoshida

Hashimoto

Nakayama

et al. 1996

Clinical and Experimental Immunology

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SUMMARYThe specific inhibitor for TNF-activity, soluble form of the 55-kD TNF receptor (sTNF-RI) and soluble form of the 75-kD receptor (sTNF-RII), and the specific inhibitor for IL-1 activity, IL-1 receptor antagonist (IL-1Ra), have been identified. It has been shown that the levels of these inhibitors are elevated in plasma/serum and biological fluids in several diseases, and the protective and inhibitory effect of these inhibitors exist in several inflammatory diseases. In the present study, we measured serum levels of sTNF-RI, STNF-RII and IL-1Ra by ELISA in 36 patients with bronchial asthma (16 atopic and 20 non-atopic) during asthma attacks and in stable conditions in order to assess the state of these inhibitors in allergic inflammation. The levels of sTNF-RI, sTNF-RII and IL-1Ra in sera obtained during bronchial asthma attacks were higher than those in sera obtained in stable conditions. These findings were obtained regardless of atopic status. These results suggest that higher levels of serum sTNF-RI, sTNF-RII and IL-1Ra may reflect up-regulation of TNF-R expression and IL-1Ra production in allergic inflammation, and sTNF-RI, sTNF-RII and IL-1Ra may contribute to regulating TNF--and IL-1-mediated production and development of allergic inflammation.

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Interleukin‐1 receptor antagonist gene polymorphism in japanese patients with systemic lupus erythematosus

Cited by 35 publications

References 6 publications

Cytokine Polymorphisms in Systemic Lupus Erythematosus and Sjögren's Syndrome

Cytokine Polymorphisms in Systemic Lupus Erythematosus and Sjögren's Syndrome

The pathophysiology of photosensitivity in lupus erythematosus

Elevation of serum soluble tumour necrosis factor (TNF) receptor and IL-1 receptor antagonist levels in bronchial asthma

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