2001
DOI: 10.1034/j.1600-0781.2001.170301.x
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The pathophysiology of photosensitivity in lupus erythematosus

Abstract: The strong association between photosensitivity and lupus erythematosus has led to the suggestion that abnormal photoreactivity participates in the pathogenesis of cutaneous lesions. In this review we discuss the evidence for abnormal cutaneous reactivity to sunlight in lupus and speculate on the cellular, molecular

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Cited by 42 publications
(30 citation statements)
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References 271 publications
(251 reference statements)
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“…Within the skin, these cytokines are thought to be produced predominately by keratinocytes and activated T cells (8,17,18). LT␣3, defined as having similar biological activity as TNF-␣, is also found to be expressed on activated keratinocytes and T cells in skin tissue, suggesting that the interaction of LT␣3 singling may also be involved in the induction of keratinocyte destruction (24).…”
Section: Discussionmentioning
confidence: 99%
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“…Within the skin, these cytokines are thought to be produced predominately by keratinocytes and activated T cells (8,17,18). LT␣3, defined as having similar biological activity as TNF-␣, is also found to be expressed on activated keratinocytes and T cells in skin tissue, suggesting that the interaction of LT␣3 singling may also be involved in the induction of keratinocyte destruction (24).…”
Section: Discussionmentioning
confidence: 99%
“…Regulation by members of the TNF superfamily of the expression of adhesion molecules has been well established (8,27,28). Both LT␣3 and TNF-␣ can up-regulate the expression of adhesion molecules such as ICAM-1 in vitro (8).…”
Section: Discussionmentioning
confidence: 99%
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