Interleukin‐1 Receptor Antagonist Gene Polymorphism, Infectious Burden, and Coronary Artery Disease

Auer, Johann; Baldassano, Robert N.; Weber, Thomas; Eber, Bernd

doi:10.1086/340531

Cited by 5 publications

(2 citation statements)

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“…After the full texts were read, four papers were excluded because they didn't provide sufficient data for calculation of OR with 95% CI [35]–[38]; two papers were excluded because of examining the associations of other genetic polymorphisms rather than the three polymorphisms studied in our analysis [39]–[40]; another paper was excluded because it was family-based study [41]. In addition, two reviews [30], [42] and two comments [43], [44] were excluded with the exception of the one by Iacoviello et al [12], which provided a new study concerning the association of IL-1RN VNTR polymorphism and CHD. Furthermore, more than one study were included in each of the two papers by Francis et al [11] and Rios et al [26], respectively, and they were considered as separate studies in the following data analysis.…”

Section: Resultsmentioning

confidence: 99%

Associations between Interleukin-1 Gene Polymorphisms and Coronary Heart Disease Risk: A Meta-Analysis

et al. 2012

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ObjectiveA great number of studies regarding the associations between IL-1B-511, IL-1B+3954 and IL-1RN VNTR polymorphisms within the IL-1gene cluster and coronary heart disease (CHD) have been published. However, results have been inconsistent. In this study, a meta-analysis was performed to investigate the associations.MethodsPublished literature from PubMed and Embase databases were searched for eligible publications. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random- or fixed- effect model.ResultsThirteen studies (3,219 cases/2,445 controls) for IL-1B-511 polymorphism, nine studies (1,828 cases/1,818 controls) for IL-1B+3954 polymorphism and twelve studies (2,987 cases/ 2,208 controls) for IL-1RN VNTR polymorphism were included in this meta analysis. The results indicated that both IL-1B-511 and IL-1B+3954 polymorphisms were not associated with CHD risk (IL-1B-511 T vs. C: OR = 0.98, 95%CI 0.87–1.09; IL-1B+3954 T vs. C: OR = 1.06, 95%CI 0.95–1.19). Similarly, there was no association between IL-1RN VNTR polymorphism and CHD risk (*2 vs. L: OR = 1.00, 95%CI 0.85–1.17).ConclusionsThis meta-analysis suggested that there were no associations between IL-1 gene cluster polymorphisms and CHD.

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Section: Resultsmentioning

confidence: 99%

Associations between Interleukin-1 Gene Polymorphisms and Coronary Heart Disease Risk: A Meta-Analysis

et al. 2012

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“…Approximately 70% of the patients in our study had raised CRP levels, but unfortunately we do not have data on atherosclerosis in this patient group. It has also been suggested recently that IL-1ra is an important factor in atherosclerosis in general [32][33][34] and in atherosclerosis related to infective agents [35]. Polymorphisms in the IL-1ra gene are associated with atherosclerosis [36] and IL-1ra-deficient mice develop severe arteritis [37].…”

Section: Discussionmentioning

confidence: 99%

Interleukin (IL)-10, IL-1ra and IL-12 profiles in active and quiescent systemic lupus erythematosus: could longitudinal studies reveal patient subgroups of differing pathology?

Capper

Maskill

Gordon

et al. 2004

Clinical and Experimental Immunology

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SUMMARYSeveral cytokines have been implicated individually in the pathogenesis of systemic lupus erythematosus (SLE) and some, including interleukin (IL)-10, IL-12 and IL-1ra are raised during flares of disease activity. Few studies have been directed at examining the interactions between these cytokines and how their combined profile relates to disease activity. We have examined serum levels of IL-10, IL-12 and IL1ra in a cohort of SLE patients obtained from the Queen Elizabeth Hospital, Birmingham in crosssectional and, in a smaller group, longitudinal analyses. In the cross-sectional study, there were significant correlations between levels of the three cytokines. There were also significant correlations between levels of each cytokine and measures of disease activity. IL-10 levels correlated with ESR, antidsDNA antibody titres and C3D, IL-12 levels with anti-dsDNA antibody titres and IL-1ra levels with ESR, anti-dsDNA antibody titres and C3D. IL-1ra levels also correlated with CRP. Circulating IL-10 and IL-1ra levels were higher in patients with SLE than in normal controls, although in this study group they did not reach significance. Circulating IL-12 levels were, however, significantly higher in SLE compared to controls. This was true both in patients with active disease and those sampled during a quiescent phase. These data add to the evidence that cytokines such as IL-10, IL-12 and IL-1ra are important in SLE pathogenesis. In a retrospective study of serial serum samples from seven patients, we found two patients whose cytokine profile was very different from the rest of the group. In most patients normalized IL-10, IL-12 and IL-1ra levels mirrored BILAG scores closely, but in these two patients, IL-10, IL-12 and IL-1ra levels did not fluctuate with disease activity. It is possible that there is a subgroup of SLE patients whose cytokine profile could be an important indicator of their pathology. In order to confirm this and determine the frequency of such patients this study needs to be repeated with a much larger subject group. The coexistence of patient groups with different patterns of cytokine activity might explain conflicting reports of associations of levels of particular cytokines with SLE. As the observed differences could reflect different aetiologies of SLE, this information could reveal valuable endophenotypes for genetic and functional studies of SLE and might, ultimately, inform therapeutic management.Keywords interleukin 1 receptor antagonist (IL-1ra) interleukin-10 (IL-10) interleukin-12 (IL-12) systemic lupus erythematosus (SLE)

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Miscellaneous Infections and Atherosclerosis: Cardiovascular and Cerebrovascular Disease

Infections and the Cardiovascular System: New Perspectives

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Interleukin‐1 Receptor Antagonist Gene Polymorphism, Infectious Burden, and Coronary Artery Disease

Cited by 5 publications

References 10 publications

Associations between Interleukin-1 Gene Polymorphisms and Coronary Heart Disease Risk: A Meta-Analysis

Associations between Interleukin-1 Gene Polymorphisms and Coronary Heart Disease Risk: A Meta-Analysis

Interleukin (IL)-10, IL-1ra and IL-12 profiles in active and quiescent systemic lupus erythematosus: could longitudinal studies reveal patient subgroups of differing pathology?

Miscellaneous Infections and Atherosclerosis: Cardiovascular and Cerebrovascular Disease

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