Interleukin-1 Production by Monocytes from Patients with Allergic Asthma after Stimulation in vitro with Lipopolysaccharide and &lt;i&gt;Dermatophagoides pteronyssinus&lt;/i&gt; Mite Allergen

Enk, Claes D.; Mosbech, H.

doi:10.1159/000234522

Cited by 8 publications

(3 citation statements)

References 7 publications

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“…collected during an acute asthma episode or after I week of CS therapy, did not show any significant difference when compared with the production of the same cytokine by PBM from healthy subjects. These results are in agreement with previous reports indicating a normal ability of monocytes from asthmatic subjects to secrete IL-I spontaneously or upon LPS stimulation [26]. Again, TNF levels were similar when this cytokine was determined in supernatants of PBM collected during acute asthma or from healthy donors.…”

Section: Discussionsupporting

confidence: 92%

Effect of corticosteroid treatment on interleukin‐1 and tumour necrosis factor secretion by monocytes from subjects with asthma

Vecchiarelli

Siracusa

Cenci³

et al. 1992

Clin Experimental Allergy

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Peripheral blood monocytes (PBM) may be activated in asthmatic patients, a condition usually reverted by corticosteroid (CS) treatment. In the present research we have evaluated the spontaneous or lipopolysaccharide (LPS)-induced production of interleukin 1 (IL-1) and tumour necrosis factor (TNF) by PBM obtained from 14 asthmatic subjects during an asthmatic attack and after 1 week of CS treatment. The control group included 20 healthy volunteers. PBM obtained during severe asthma showed a pattern of IL-1 and TNF secretion similar to that of normal subjects. After CS treatment, IL-1 levels did not change significantly in comparison to baseline values, while LPS-induced TNF production was apparently related to the degree of airway obstruction after CS treatment. In fact, TNF production by PBM from CS-responsive subjects was significantly decreased in comparison to the levels determined before CS treatment, while PBM from CS-resistant subjects produced the same cytokine levels regardless of CS treatment. The present study suggests that the determination of LPS-induced TNF secretion by PBM could be used to confirm the effectiveness of CS treatment in asthma.

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Section: Discussionsupporting

confidence: 92%

Effect of corticosteroid treatment on interleukin‐1 and tumour necrosis factor secretion by monocytes from subjects with asthma

Vecchiarelli

Siracusa

Cenci³

et al. 1992

Clin Experimental Allergy

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“…Df antigen‐induced IL‐1α, IL‐1β production by the PBMC of patients with active bronchial asthma, unlike that by the cells of non‐asthmatic subjects, was increased after antigen‐driven restimulation in vitro, but the difference was not significant. These results are supported by the report that when stimulated with D. pteronyssinus antigen, monocytes from patients with allergic asthma have the same ability to produce IL‐1 as monocytes from healthy controls [ 17]. In contrast, in our patients with remission of asthma symptoms, Df‐induced IL‐1α, IL‐1β production surprisingly showed a significant decrease.…”

Section: Discussionsupporting

confidence: 89%

Reduced IL-1 production in adolescents with mite antigen asthma in remission

Noma

Ichikawa

Yoshizawa

et al. 1998

Clinical and Experimental Immunology

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SUMMARYTo determine the immunological mechanisms associated with outgrowing mite antigen-induced bronchial asthma during adolescence, we studied the relationship between clinical status and Dermatophagoides farinae (Df) antigen-induced peripheral cell activation by measuring IL-1a and IL-lb production in patients with bronchial asthma. After antigen-driven restimulation in vitro, there was increased IL-1a, IL-1b production by peripheral blood mononuclear cells (PBMC) from patients with active bronchial asthma, while cellular IL-1a, IL-1b production was reduced in patients with asthma in remission. IL-1a and IL-1b production by PBMC (possibly reflecting airway inflammation) after exposure to Df antigen might be down-regulated in patients outgrowing mite antigen-induced asthma, because lipopolysaccharide-induced IL-1a, IL-1b production (seen in both normal individuals and patients with active asthma) was also reduced when patients were in remission.

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“…Monocytes from six patients with asthma and a positive bronchial challenge with extract from the house dust mite Dermatophagoides pteronyssinus (Dp) were stimulated with lipopolysaccharide (LPS) and the allergen extract from Dp (Enk et al, 1988).…”

Section: A Effect On Host Immune Systemmentioning

confidence: 99%

Bioactive Compounds in Tick and Mite Venoms (Saliva)

Motoyashiki

Azimov

2005

Toxin Reviews

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Ticks and mites are bloodsucking ectoparasites containing anticoagulants as well as many other bioactive compounds. Because of their extremely small size, collection of venom (saliva) is very difficult. Therefore, the scientific study of tick and mite venoms is far less well developed than that of other venoms such as snake, scorpion, and bee. In this review article, anticoagulant components, paralytic toxins, and the effect of venom on the immune system are reviewed. Anticoagulants are discussed in three parts, namely inhibition of thrombin, inhibition of factor X activation, and effect on other blood coagulation factors. Among the venom (saliva) components, lipids, enzymes, and other bioactive components are discussed. Paralysis is discussed without further subdivision. Immunological considerations are reviewed in two ways: their effect on host immune system, and efforts to develop vaccines and toxoids. All together 142 references were quoted.

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Interleukin-1 Production by Monocytes from Patients with Allergic Asthma after Stimulation in vitro with Lipopolysaccharide and <i>Dermatophagoides pteronyssinus</i> Mite Allergen

Cited by 8 publications

References 7 publications

Effect of corticosteroid treatment on interleukin‐1 and tumour necrosis factor secretion by monocytes from subjects with asthma

Effect of corticosteroid treatment on interleukin‐1 and tumour necrosis factor secretion by monocytes from subjects with asthma

Reduced IL-1 production in adolescents with mite antigen asthma in remission

Bioactive Compounds in Tick and Mite Venoms (Saliva)

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