Interleukin‐1 (IL‐1) bioactivity and inhibition of IL‐1 bioactivity in supernatant fluid from cultured microphthalmic (<i>mi</i>) mice teeth of different ages

Symons, A. L.; Polak, B.; Powell, R. N.; Seymour, G. J.

doi:10.1111/j.1600-0714.1995.tb01201.x

Cited by 5 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the localization of EGF in osteoclasts (21) and its ability to stimulate resorption by osteoclasts (22) implies a role for this growth factor during the formation of an eruption pathway. It has been shown that EGF stimulates synthesis of interleukin‐1 alpha (IL‐1α) in the stellate reticulum (23) and IL‐1α has been detected in the supernatants collected from cultured rat molars (24). It is a potent bone‐resorbing agent (25), promoting osteoclast‐like cell formation from marrow cells (26) and inducing the multinucleation and bone resorbing activity of osteoclasts (27).…”

mentioning

confidence: 99%

Reduced growth hormone receptor immunoreactivity in osteoclasts adjacent to the erupting molar in the incisor‐absent (osteopetrotic) rat

Symons

2003

European J Oral Sciences

View full text Add to dashboard Cite

First molars fail to erupt in the incisor-absent (ia/ia) rat because of a defect in osteoclast function. Growth factors that regulate local bone metabolism include growth hormone (GH), insulin-like growth factor-I (IGF-I), epidermal growth factor (EGF) and interleukin-1 alpha (IL-1alpha). Since osteoclast function may be affected by these factors, the aim of this study was to determine the distribution of GH receptor (GHr), IGF-I, EGF and IL-1alpha, in osteoclasts located occlusal to the erupting first molar, in the 'eruption pathway', in normal and ia/ia rats. Sagittal sections of the first molar and adjacent bone from 3- and 9-d-old animals were examined. Osteoclasts were identified using tartrate-resistant acid phosphatase (TRAP). The TRAP-positive osteoclast cell numbers were higher in ia/ia animals at 3 and 9 days-of-age. In the ia/ia group, fewer osteoclasts were GHr- and IGF-I-positive at 3 d of age, and at 9 d of age fewer osteoclasts were GHr-positive. In the ia/ia rat, defective osteoclast function failed to resorb bone to provide an eruption pathway for the lower first molar. The expression of GHr, and to some degree IGF-I, by these osteoclasts was reduced, which may be related to their ability to differentiate and function.

show abstract

mentioning

confidence: 99%

Reduced growth hormone receptor immunoreactivity in osteoclasts adjacent to the erupting molar in the incisor‐absent (osteopetrotic) rat

Symons

2003

European J Oral Sciences

View full text Add to dashboard Cite

show abstract

“…A functioning dental follicle and bone resorption are necessary for tooth eruption. Local bone metabolism involves the production of cytokines, such as interleukin‐1α and transforming growth factor‐β 15 . The production of these cytokines by dental tissues during eruption could trigger, with the release of interleukins, the degranulation of mastocytes and blistering.…”

Section: Discussionmentioning

confidence: 99%

Solitary mastocytoma: tooth eruption as triggering factor

et al. 2008

View full text Add to dashboard Cite

A 2‐month‐old white male infant presented with a slightly infiltrated, brownish‐erythematous plaque on the left arm a few days after birth (following normal physiologic pregnancy and parturition). His parents noted the development of a flaccid bulla on the site of the lesion after a fever and sought the aid of a specialist. The child presented no other general symptoms. At presentation, there was a blood serum‐filled flaccid bulla surrounded by seemingly healthy skin (Fig. 1). Rubbing of the skin surrounding the bulla produced a hive‐like reaction (Darier's sign). With the suspicion of a cutaneous mastocytoma, an incisional cutaneous punch biopsy was obtained (4 mm in diameter). 1 A blood serum‐filled flaccid bulla surrounded by seemingly healthy skin on the left arm of a 2‐month‐old white male infant Histopathologic examination showed a monomorphous and dense proliferation of mast cells within the superficial and deep dermis. Neoplastic cells displayed moderately abundant, oval‐ or polygonal‐shaped cytoplasm and round to oval nuclei (Fig. 2). The nuclei were characterized by clumped chromatin and indistinct or inapparent nucleoli. The cytoplasm was filled with small, faintly visible, eosinophilic or amphiphilic granules which stained metachromatically with Giemsa stain (Fig. 3). Scattered eosinophils were observed throughout the lesion. A final diagnosis of nodular mastocytoma was made. 2 Hematoxylin and eosin stain showing a dermal monomorphous proliferation of cells characterized by moderately abundant, oval‐ or polygonal‐shaped cytoplasm and round to oval nuclei (original magnification, ×20) 3 Giemsa stain showing metachromatic small granules within the cell cytoplasm (original magnification, ×20) Having followed the lesion's evolution for 3 years, we have observed that it has been affected periodically by blistering, together with sudden episodes of flushing lasting 15–20 min, in the presence of triggering factors such as fevers or vaccinations. The most recent episodes occurred between the age of 15 and 24 months, and were associated with the eruption of deciduous teeth. Over the past few months, with the patient now approximately 3 years of age, the lesion has grown progressively lighter and is beginning to disappear (Fig. 4). 4 After the age of 2 years, the mastocytoma became progressively lighter and smaller

show abstract

Dental follicle cell-conditioned medium enhances the formation of osteoclast-like multinucleated cells

Kawakami

Kuroda²,

Yoshida³

et al. 2000

The European Journal of Orthodontics

View full text Add to dashboard Cite

Interleukin‐1 (IL‐1) bioactivity and inhibition of IL‐1 bioactivity in supernatant fluid from cultured microphthalmic (mi) mice teeth of different ages

Cited by 5 publications

References 32 publications

Reduced growth hormone receptor immunoreactivity in osteoclasts adjacent to the erupting molar in the incisor‐absent (osteopetrotic) rat

Reduced growth hormone receptor immunoreactivity in osteoclasts adjacent to the erupting molar in the incisor‐absent (osteopetrotic) rat

Solitary mastocytoma: tooth eruption as triggering factor

Dental follicle cell-conditioned medium enhances the formation of osteoclast-like multinucleated cells

Contact Info

Product

Resources

About