Interleukin-1 Genotype in Periodontitis

Abstract

This paper presents the current knowledge concerning the role of polymorphisms of IL1A and IL1B genes in periodontitis. Attention has been paid to the role of IL-1 in the pathogenesis of the disease, and to the significance of a genetic test, investigating the presence of composite two polymorphisms of IL-1 gene, as a risk factor for severe periodontitis. The significance of this test for prevention of periodontitis and its therapy has been discussed. IL-1 polymorphisms have been presented and described according to the reference single nucleotide polymorphism (SNP) identification number (rsID), established to eradicate the redundancy of reported polymorphisms in the SNP database processed by the National Center for Biotechnology Information. The prevalence of these genotypes in different populations and ethnic groups and its effect on periodontal health have been discussed. The presented data show inconsistent results. It seems that at least two polymorphisms, rs1800587 and rs1143634, are associated with periodontal inflammation. Therefore, they can be regarded as candidate genes involved in further periodontitis risk assessment. It seems that geographical and ethnical factors can play a great role, as the prevalence of specific polymorphisms varies greatly depending on the population studied.

Comprehensive Analysis of Risk Factors for Periodontitis Focusing on the Saliva Microbiome and Polymorphism

“…The prevalence of periodontitis was significantly associated with the salivary microbiome, but not with SNPs. Some studies showed the association between SNPs and periodontitis [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ], but few studies assessed the relationships among polymorphisms, the microbiome, and periodontitis simultaneously. The results showed that the microbiome, rather than SNPs, affected the prevalence of periodontitis.…”

“…After genotype imputation, variants with an R 2 < 0.3 were excluded, resulting in 12,617,547 variants. Of the SNPs that passed quality control, 51 SNPs related to periodontitis were identified [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ].…”

Associations between Interleukin Gene Polymorphisms and Risks of Developing Extremity Posttraumatic Osteomyelitis in Chinese Han Population

“…They participate in systemic inflammation and play vital roles in innate and adaptive immunity. Previous studies had indicated that IL gene SNPs associate with the development of both bacteria-and virus-related inflammatory disorders, such as sepsis [9,10], periodontitis [11,12], hepatitis B [13], and C [14] virus infections. However, current studies were still limited regarding the potential associations between IL gene SNPs and the risks of developing PTOM, especially in Chinese population.…”

Sex Variations in the Oral Microbiomes of Youths with Severe Periodontitis

“…In contrast to our results, when Belstrøm et al used microarrays to examine the oral microbiomes of 292 Danish individuals with low levels of dental caries and periodontitis, they found that diet, BMI, age, and sex did not significantly affect microbial abundance, though socioeconomic status affected the oral microbiome profiles [ 42 ]. Other possible factors could explain the differences observed in our study, including genetic variations, social factors, chronology of tooth eruption, and hormonal differences, which could affect the composition of the plaque microbiomes [ 14 , 43 ].…”