Interleukin-1 associations in inflammatory bowel disease and the enteropathic seronegative spondylarthritis

Abstract

PurposeThis study aims to investigate any associations of the proinflammatory cytokine IL-1 in treated patients with inflammatory bowel disease (IBD) and the enteropathic seronegative spondylarthritis (eSpA).MethodsThirty-four patients with Crohn’s disease (CD), 26 with ulcerative colitis (UC) and 14 patients with SpA participated in the study. Valid clinical indexes, CRP values and the endoscopic and histologic examination were used for the determination of disease activity. IL-1α, IL-1β, IL-1 receptor antagonist (IL-1Ra) were measured by ELISA. Nonparametric tests were used for continuous and categorical data.ResultsEnteropathic SpA diagnosed in 29.4 % CD and 30.8 % UC patients. Active disease had 58.8 % CD (aCD), 76.9 % UC and 50 % SpA patients. Active and inactive CD (iCD) significantly differ on IL-1α levels (11.2 vs. 3.9 pg/ml; p = 0.034). Active and inactive UC significantly differ on IL-1β (3.7 vs. 2.3 pg/ml; p = 0.054) and IL-1Ra levels (15.9 vs. 12.7 pg/ml; p = 0.023). Active and inactive SpA (iSpA) significantly differ on IL-1Ra (16.9 vs. 14.8 pg/ml; p = 0.033) and marginally on IL-1α levels (20 vs. 3.9 pg/ml; p = 0.06). Patients with aCD/ieSpA exhibited significant differences on IL-1α (p = 0.022) compared to those with iCD/ieSpA.ConclusionsIL-1α is associated with CD activity, while IL-1β and IL-1Ra are associated with UC activity in treated patients with IBD. Prominent cytokine in SpAs seems to be IL-1α.

p-Cymene and Rosmarinic Acid Ameliorate TNBS-Induced Intestinal Inflammation Upkeeping ZO-1 and MUC-2: Role of Antioxidant System and Immunomodulation

“…IL-1β and TNF-α may alter epithelial permeability and facilitate the infiltration of inflammatory cells contributing to tissue damage. Furthermore, they mediate chronic intestinal inflammation by promoting the accumulation of IL-17A-secreting innate lymphoid cells and Th17 CD4 + cells [60][61][62]. Studies have revealed increased frequencies of activated cytotoxic T cells (CD8 + ) in active stages of IBDs close to the epithelial cells that may further exacerbate the inflammatory process through the production of TNF-α and IFN-γ, leading to the increased influx of luminal antigens through epithelial lesions [63,64].…”

Anthocyanins and intestinal barrier function: a review

“…IL-1α and IL-1β are mediators of the acute phase of IBD (Vounot-rypidis et al, 2013). In the context of IBD, IL-1α seems to be associated with CD, while IL-1β expression is enhanced in active UC (Vounotrypidis et al, 2013). IL-1β induces the delocalization of ZO-1 and occludin from the TJ, eliminating their effectiveness in maintaining the intestinal barrier.…”

The role of dietary polyphenols in inflammatory bowel disease: A possible clue on the molecular mechanisms involved in the prevention of immune and inflammatory reactions

“…Pro-inflammatory cytokines such as TNF-ɑ and IL-1 had a pivotal role to play during acute phase responses in IBD (Vounotrypidis et al, 2013). IL-1 includes IL-1ɑ and IL-1β, which are the key cy- growth factor β are regarded as anti-inflammatory or immunosuppressive cytokines (Neuman, 2004).…”