Anthocyanins and intestinal barrier function: a review

Valdez, Jonathan C.; Bolling, Bradley W.

doi:10.31665/jfb.2019.5175

Cited by 20 publications

(18 citation statements)

References 128 publications

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“…Thus, fruits having ferulic acid with epigallocatechins appeared to be more effective inhibiting IC-induced barrier dysfunction in Caco-2 cells. Prior studies have also demonstrated the ability of FA to inhibit inflammation and protect gastrointestinal cells and TJ [24][25][26]. FA in Gulupa, Maracuyá, and Granadilla extracts showed TEER improvement (Table 3) of Caco-2 cells.…”

Section: Discussionmentioning

confidence: 79%

“…Caco-2 cells were treated with an inflammatory cocktail (IC) consisting of inflammatory cytokines IL-1β (25 ng/mL), TNF-α (50 ng/mL), IFN-γ (50 ng/mL), and pro-inflammatory lipopolysaccharide (LPS) (1 mg/mL) for 48 h. The IC was formulated to model intestinal barrier dysfunction induced by chronic inflammation as described previously [24]. Growth media, as a control, of the IC (880 µL) were pipetted into the basolateral compartment of Transwell plates.…”

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confidence: 99%

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Polyphenol Extracts from Three Colombian Passifloras (Passion Fruits) Prevent Inflammation-Induced Barrier Dysfunction of Caco-2 Cells

et al. 2019

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Chronic intestinal inflammation is associated with pathophysiology of obesity and inflammatory bowel diseases. Gastrointestinal inflammation increases barrier dysfunction exacerbating the immune response and perpetuating chronic inflammation. Anti-inflammatory flavonoids may prevent this intestinal barrier dysfunction. The purpose of this study was to evaluate the polyphenol composition of Colombian Passiflora edulis var. Flavicarpa (Maracuyá), Passiflora edulis var. Sims (Gulupa), and Passiflora ligularis var. Juss (Granadilla) (passion fruits) and to evaluate their ability to inhibit disruption of intestinal barrier dysfunction of Caco-2 (colorectal adenocarcinoma) cells by an inflammatory cocktail (IC). Polyphenols (flavan-3-ols, phenolic acids, flavonols), xanthenes, and a terpene were identified in passion fruits. Cyanidin 3-rutinoside, (+)-catechin and ferulic acid were the most abundant phenolics in P. edulis var. Flavicarpa, P. edulis var. Sims, and P. ligularis var. Juss, respectively. Fruit extracts prevented loss of transepithelial electrical resistance in Caco-2 cells treated with the IC. Among the extracts, P. ligularis var. Juss was most effective at maintaining Caco-2 transepithelial electrical resistance (TEER) with ~73% relative to the IC-treated cells with about 43% of initial TEER values. This fruit had cyanidin-3-rutinoside, (+)-catechin, (−)-epicatechin, and ferulic acid in its phenolic profile. Results of this work support the hypothesis that consumption of passion fruit extracts could benefit intestinal health.

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Section: Discussionmentioning

confidence: 79%

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confidence: 99%

Polyphenol Extracts from Three Colombian Passifloras (Passion Fruits) Prevent Inflammation-Induced Barrier Dysfunction of Caco-2 Cells

et al. 2019

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“…The protective effect of consumption of phenolic-rich grains, legumes, berries, nuts, and oilseeds against several chronic diseases was demonstrated by several researcher groups (Valdez et al, 2019;Shahidi et al, 2019aShahidi et al, , 2019b.…”

Section: Introductionmentioning

confidence: 99%

Amber, red and blue LEDs modulate phenolic contents and antioxidant activities in eight Cruciferous microgreens

Alrifai¹,

Hao²,

Liu³

et al. 2020

Journal of Food Bioactives

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Grass pea seeds of 30 varieties from Poland, Slovakia, Czech, Russia, Ukraine, Hungary, Bulgaria, India, Iran, Tunisia, Ethiopia, Canada, and Chile were investigated. Phenolic compounds were extracted from seeds into 80% (v/v) methanol. The total phenolics compounds content of the extracts was determined using Folin-Ciocalteu’s phenol reagent. The antioxidant activity was determined using ABTS and FRAP assays. Total phenolic contents ranged from 2.74 to 10.7 mg/g extract and from 35.9 to 144.7 mg/100 g seeds. The extracts and seeds were characterized using Trolox equivalent antioxidant capacity values of 0.014–0.060 mmol Trolox/g extract and 0.188–0.866 mmol Trolox/100 g seeds, and FRAP values of 0.188–0.866 mmol Fe2+/g extract and 0.541–1.398 Fe2+/100 g seeds. The total phenolics content of grass pea extract was correlated with the results of the ABTS (r = 0.854) and FRAP (r = 0.958) assays. A similar correlation existed between the results of both assays (r = 0.890). Phenolic acids were the dominant phenolic compounds of two cultivars of grass pea. Syringic and sinapic acids had the highest amounts while ferulic, p-hydroxybenzoic, protocatechuic, and p-coumaric acids were present in much lower quantitie. Phenolic acids were present in the form of free compounds, esters, and glycosides.

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“…Blue flowers such as cornflower, blue chicory and blue rosemary and purple flowers such as purple mint, purple passionflower, purple sage, common violet and lavender are the common edible flowers. Some of the fruits containing anthocyanins include cherries, plums, strawberries, raspberries, blackberries, grapes, red currants and black currants (Shahidi and Ambigaipalan, 2015;Valdez and Bolling, 2019). Stability of anthocyanins is dependent on the type of anthocyanin pigment, copigments, metal ions, light, pH, temperature, oxygen, enzymes and antioxidants (Castañeda-Ovando et al, 2009;Khoo et al, 2017;Pietta et al, 2003).…”

Section: Anthocyanidins and Anthocyaninsmentioning

confidence: 99%

Bioavailability and metabolism of food bioactives and their health effects: a review

Shahidi¹,

Ramakrishnam²,

Oh³

2019

Journal of Food Bioactives

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Numerous studies have demonstrated the availability of high-quality bioactive compounds in food along with their determination and quantification techniques. Many of these identified compounds have been claimed to possess health benefits such as anti-inflammatory, anti-cancer, antioxidant, anti-allergic, anti-fungal, antimicrobial and cardioprotective spasmolytic properties. However, mere presence of these compounds does not directly correlate with their potential health effects upon consumption. Since any food consumed does not reach the blood stream in the original form and as they are broken down to various compounds it is mandatory to consider their bioavailability and metabolism that takes place upon absorption. Furthermore, the efficacy of these bioactive compounds depends on various factors including the dosage, food matrix and stability of the compound during metabolism. Various bioavailability studies indicate that the parent bioactive compound is broken into various metabolites via oxidation, dehydroxylation, de-esterification, hydrolysis, carboxylation, α- and β-oxidation processes inside the human body. Therefore, this leads to an interesting conundrum that whether the proposed health effects are due to the parent bioactive compound or due to the metabolites formed during absorption. Some details in relation to the metabolism and metabolites of food bioactives are presented in this contribution.

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Anthocyanins and intestinal barrier function: a review

Cited by 20 publications

References 128 publications

Polyphenol Extracts from Three Colombian Passifloras (Passion Fruits) Prevent Inflammation-Induced Barrier Dysfunction of Caco-2 Cells

Polyphenol Extracts from Three Colombian Passifloras (Passion Fruits) Prevent Inflammation-Induced Barrier Dysfunction of Caco-2 Cells

Amber, red and blue LEDs modulate phenolic contents and antioxidant activities in eight Cruciferous microgreens

Bioavailability and metabolism of food bioactives and their health effects: a review

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