INTERLEIKIN 1 KAK MEDIATOR VOSPALENIYa I TERAPEVTIChESKAYa MIShEN''

Ильина, Анна Евгеньевна; Stanislav, Marina; Денисов, Л. Н.; Насонов, Е. Л.

doi:10.14412/1995-4484-2011-1463

Cited by 5 publications

(1 citation statement)

References 86 publications

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“…ИЛ1 -плейотропный «провоспалительный» цитокин, играющий фундаментальную роль в развитии многих острых и хронических ИВЗ человека [6][7][8][9][10][11]. ИЛ1 -основной пред-ставитель семейства цитокинов, включающего 11 молекул: ИЛ1α, ИЛ1β, рецепторный антагонист ИЛ1 (ИЛ1Ра), ИЛ18, ИЛ33, четыре изоформы ИЛ36 (ИЛ36α, ИЛ36β, ИЛ36γ, ИЛ36Ра), ИЛ37 и ИЛ38 [12].…”

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Role of Interleukin 1 in the Development of Human Diseases

Насонов¹,

Елисеев²

2016

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Role of Interleukin 1 in the Development of Human Diseases

Насонов¹,

Елисеев²

2016

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Influence of <i>Helicobacter pylori</i> on cytokine regulation in chronic atrophic gastritis

Смирнова

Синяков

2020

Russian Journal of Infection and Immunity

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At present, the level of Helicobacter pylori infection is determined by geographic area, gender and age of the examined individuals, and can reach up to 95% of the total population. Environmental adaptation of H. pylori is exhibited in its ability to adhere to the gastric mucosal epithelium and modulated expression of its own virulent factors. Current concepts implicate that H. pylori can survive inside epithelial cells, evading host immune response. Cytokines are produced by immune cells and act to regulate its major stages. A cytokine cascade launched after Helicobacter pylori infection triggers immune reactions, progression of chronic inflammatory and destructive processes in the gastric mucosa. The role of cytokines in precancerous diseases of the stomach is ambiguous because, on the one hand, they activate immune response aimed at eliminating the pathogen, whereas on the other hand, they do contribute to the disease progression. The aim of our study was to examine profile of some cytokines and features of cytokine regulation in H. pylori-infected middle-aged males with chronic gastritis (CG) as well as chronic atrophic gastritis (CAG). In patients with CG with H. pylori, CAG and CAG with H. pylori, an increase in the cytokine IL-2 was observed that might contribute to augmented damaging effect of cytotoxic lymphocytes, as well as implementation of antitumor effect. CAG with H. pylori was featured with IL-8 hyperproduction, which resulted in increased absolute numbers of band neutrophils in peripheral blood and their decreased phagocytic activity evidencing about altered host defense mechanisms. There was increased amount of IFNy involved in recognition of malignantly transformed cells and upregulated expression of the major histocompatibility complex molecules on antigen-presenting cells. In patients with CG with H. pylori and CAG with H. pylori, production of IL-4 was increased, which might serve as a contributing factor to the chronicity of H. pylori-associated diseases. Overproduction of type 1 and type 2 cytokines indicates about activated Th1 and Th2 type immune reactions in H. pylori-associat-ed CG. A potent pro-inflammatory cytokine cascade triggers inflammatory changes in gastric mucosa with developing neutrophil infiltration and lymphocyte activation. Damage and death of epithelial cells upon inflammation form erosive and ulcerative defects, or changes manifested as gastric mucosal atrophy, metaplasia and neoplasia. The data obtained may be used as additional diagnostic criteria in early diagnostics of precancerous stomach diseases.

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Inflammatory response and its role in antenatal transformation of the cervix

et al. 2020

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Understanding how the cervical tissue changes before childbirth is one of the most significant issues of modern-day obstetrics. This article reviews current original research findings by domestic and foreign authors in the field of antenatal cervical transformation mechanisms. Cellular and humoral components of inflammation in the cervix are presented as the most significant causes of morphological changes in cervical tissues. The perspectives of further research in the field have been stated in this review.

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INTERLEIKIN 1 KAK MEDIATOR VOSPALENIYa I TERAPEVTIChESKAYa MIShEN''

Cited by 5 publications

References 86 publications

Role of Interleukin 1 in the Development of Human Diseases

Role of Interleukin 1 in the Development of Human Diseases

Influence of <i>Helicobacter pylori</i> on cytokine regulation in chronic atrophic gastritis

Inflammatory response and its role in antenatal transformation of the cervix

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