Interictal Cognitive Deficits in Migraine Sufferers: A Meta-Analysis

Braganza, Dion L; Fitzpatrick, Lauren E.; Nguyen, Mai; Crowe, Simon F.

doi:10.1007/s11065-021-09516-1

Cited by 10 publications

(10 citation statements)

References 57 publications

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“…Different animal models of migraine used in the two studies might be a major cause for the contradictory results. Several clinical neuropsychological researches reported that cognitive symptoms in migraine patients are mainly presented as visuospatial abilities, processing speed, attention and executive functions [ 3 – 6 ]. Moreover, neuroimaging studies have revealed that the structural and functional alterations in the cerebral cortex and hippocampus were involved in cognitive impairment in migraine patients [ 5 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Migraine is the second most common form of headache disorder [ 1 ], and is the second leading cause of disability worldwide [ 2 ]. Cognitive symptoms, particularly impairment in visuospatial abilities, processing speed, attention, memory and executive functions [ 3 – 6 ], ranked second resulting in migraine-related disability, after pain [ 7 ]. Thus, there is an urgent need to identify the mechanisms and effective interventions for migraine-related cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

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P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine

et al. 2022

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Migraine is the second most common form of headache disorder and the second leading cause of disability worldwide. Cognitive symptoms ranked second resulting in migraine-related disability, after pain. P2X7 receptor (P2X7R) was recently shown to be involved in hyperalgesia in migraine. However, the role of P2X7R in migraine-related cognitive impairment is still ill-defined. The aim of this study was to explore the molecular mechanisms underlying migraine-related cognitive impairment and the role of P2X7R in it. Here we used a well-established mouse model of migraine that triggered migraine attacks by application of inflammatory soup (IS) to the dura. Our results showed that repeated dural IS stimulation triggered upregulation of P2X7R, activation of NLRP3 inflammasome, release of proinflammatory cytokines (IL-1β and IL-18) and activation of pyroptotic cell death pathway. Gliosis (microgliosis and astrogliosis), neuronal loss and cognitive impairment also occurred in the IS-induced migraine model. No significant apoptosis or whiter matter damage was observed following IS-induced migraine attacks. These pathological changes occurred mainly in the cerebral cortex and to a less extent in the hippocampus, all of which can be prevented by pretreatment with a specific P2X7R antagonist Brilliant Blue G (BBG). Moreover, BBG can alleviate cognitive impairment following dural IS stimulation. These results identified P2X7R as a key contributor to migraine-related cognitive impairment and may represent a potential therapeutic target for mitigating cognitive impairment in migraine.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine

et al. 2022

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“…Detailed descriptions of the subclinical neuropsychological features of PwM are beyond the scope of the present paper, and comprehensive reviews are already available on the subject [ 23 , 24 , 25 ]. Thus, only the main findings will be reported in this section.…”

Section: Cognitive Profiles In Migraineursmentioning

confidence: 99%

“…However, migraine is associated with slight cognitive dysfunctions also during the interictal periods. These appear in tasks involving complex attention and executive functioning, including set-shifting, spatial cognition, and immediate and delayed memory [ 24 , 25 , 28 ]. The deficits also affected global cognition, with a more prominent effect in PwM without aura [ 24 ].…”

Section: Cognitive Profiles In Migraineursmentioning

confidence: 99%

“…These appear in tasks involving complex attention and executive functioning, including set-shifting, spatial cognition, and immediate and delayed memory [ 24 , 25 , 28 ]. The deficits also affected global cognition, with a more prominent effect in PwM without aura [ 24 ]. They are influenced by the frequency and severity of the attacks [ 29 ].…”

Section: Cognitive Profiles In Migraineursmentioning

confidence: 99%

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Migraine Pharmacological Treatment and Cognitive Impairment: Risks and Benefits

Russo

Rosa

Consoli

et al. 2022

IJMS

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Migraine is a common neurological disorder impairing the quality of life of patients. The condition requires, as an acute or prophylactic line of intervention, the frequent use of drugs acting on the central nervous system (CNS). The long-term impact of these medications on cognition and neurodegeneration has never been consistently assessed. The paper reviews pharmacological migraine treatments and discusses their biological and clinical effects on the CNS. The different anti-migraine drugs show distinct profiles concerning neurodegeneration and the risk of cognitive deficits. These features should be carefully evaluated when prescribing a pharmacological treatment as many migraineurs are of scholar or working age and their performances may be affected by drug misuse. Thus, a reconsideration of therapy guidelines is warranted. Furthermore, since conflicting results have emerged in the relationship between migraine and dementia, future studies must consider present and past pharmacological regimens as potential confounding factors.

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Cognitive Impairment in Primary and Secondary Headache Disorders

Dhaem

Robbins

2022

Curr Pain Headache Rep

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Purpose of ReviewTo critically evaluate the recent literature on cognitive impairment and headache. Recent Findings Neurocognitive symptoms are prevalent, debilitating, and occur often with both primary and secondary headache disorders. Summary This is a "narrative review of the current literature in PubMed on cognitive function and headache." Migraine is associated with cognitive impairment years before a migraine diagnosis. In young and middle-aged adults, migraine is associated with deficits in attention, executive function, processing speed, and memory. It is unlikely that migraine is associated with dementia. Although methodologically difficult to assess, there does not seem to be an association between tension-type headache and cognitive dysfunction. In early to midlife, cluster headache seems to be associated with executive dysfunction. Several secondary headache syndromes relevant to clinicians managing headache disorders are associated with poorer cognitive performance or distinctive cognitive patterns, including those attributed to chronic cerebral or systemic vascular disorders, trauma, and derangements of intracranial pressure and volume, including frontotemporal brain sagging syndrome.

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Interictal Cognitive Deficits in Migraine Sufferers: A Meta-Analysis

Cited by 10 publications

References 57 publications

P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine

P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine

Migraine Pharmacological Treatment and Cognitive Impairment: Risks and Benefits

Cognitive Impairment in Primary and Secondary Headache Disorders

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