Cognitive Impairment in Primary and Secondary Headache Disorders

Dhaem, Olivia Begasse de; Robbins, Matthew S.

doi:10.1007/s11916-022-01039-5

Cited by 8 publications

(3 citation statements)

References 161 publications

(187 reference statements)

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“…Migraine can negatively impact work productivity even on non-headache days as 40% of people with migraine have interictal symptoms such as cognitive impairments (e.g. deficits in attention, executive function, processing speed, and memory) [ 15 , 16 ]. In addition to migraine-related cognitive dysfunction, cogniphobia may interfere with work productivity too [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Migraine in the workplace

Dhaem

Sakai²

2022

eNeurologicalSci

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Section: Introductionmentioning

confidence: 99%

Migraine in the workplace

Dhaem

Sakai²

2022

eNeurologicalSci

Self Cite

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“…In addition, cognitive and affective deficits in brain tumor patients are related to various clinical factors, such as tumor size, tumor growth rates, 1 abnormal neurotransmitter activity, 45 headaches, 46 and epilepsy. 47 In our study, we observed that cognitive and affective impairments were primarily associated with larger tumor size in PitNET patients, rather than the duration of the disease course.…”

Section: Factors Impacting Cognitive and Affective Functioning In Pit...mentioning

confidence: 99%

Pituitary neuroendocrine tumor: A neuropsychological comparison with intra‐axial tumor

Tang,

Fang,

Bie

et al. 2024

Ann Clin Transl Neurol

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ObjectiveDespite pituitary neuroendocrine tumor (PitNET) being extra‐axial tumors without direct damage to brain tissue, patients with PitNET exhibit neuropsychological impairments. However, it remains unclear whether there are neuropsychological differences between PitNET and intra‐axial tumors that directly destroy the brain parenchyma. This prospective study aims to clarify this distinction to inform decision‐making for intracranial tumors of diverse origins.MethodsA total of 146 patients with PitNET, 74 patients with glioma representing intra‐axial tumors, and 52 age‐, sex‐, and education‐matched healthy controls were recruited. All patients received standard treatment and postoperative rehabilitation. Clinical data were meticulously collected, and neuropsychological tests were administered to all participants both before and 3 months after surgery.ResultsBoth PitNET and glioma patients experience the dual burden of cognitive and affective deficits. However, the feature of these deficits differs substantially. In PitNET patients, the deficits are relatively mild and focal, whereas in glioma patients, they are severe and extensive. Specifically, PitNET patients exhibit deficits in memory, anxiety, and negative affect. In contrast, glioma patients display deficits in executive function, attention, anxiety, positive/negative affect, and empathy. Notably, except for persistent memory deficits, the majority of neuropsychological scores declines in PitNET patients are restorable and can reach improvement within a short period after standard surgical therapy and perioperative management. Conversely, glioma patients not only fail to show improvements but also demonstrate worsening in terms of general cognition and memory postoperatively.InterpretationAs an extra‐axial tumor, PitNET may exhibit distinctive cognitive and affective functioning compared to intra‐axial tumors, highlighting the need for specific treatment approaches for PitNET patients.

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“…The two conditions are significantly debilitating and represent a significant burden on health systems [ 1 ]. Recent investigations have attempted to assess links between the two conditions, but, in most cases, the results were conflicting and inconclusive [ 2 ]. While an increased risk for mid-to-late-life cognitive impairment in migraineurs [ 3 , 4 , 5 , 6 , 7 ] has been frequently reported, fewer observations have contradicted the notion [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Migraine Pharmacological Treatment and Cognitive Impairment: Risks and Benefits

Russo

Rosa

Consoli

et al. 2022

IJMS

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Migraine is a common neurological disorder impairing the quality of life of patients. The condition requires, as an acute or prophylactic line of intervention, the frequent use of drugs acting on the central nervous system (CNS). The long-term impact of these medications on cognition and neurodegeneration has never been consistently assessed. The paper reviews pharmacological migraine treatments and discusses their biological and clinical effects on the CNS. The different anti-migraine drugs show distinct profiles concerning neurodegeneration and the risk of cognitive deficits. These features should be carefully evaluated when prescribing a pharmacological treatment as many migraineurs are of scholar or working age and their performances may be affected by drug misuse. Thus, a reconsideration of therapy guidelines is warranted. Furthermore, since conflicting results have emerged in the relationship between migraine and dementia, future studies must consider present and past pharmacological regimens as potential confounding factors.

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Cognitive Impairment in Primary and Secondary Headache Disorders

Cited by 8 publications

References 161 publications

Migraine in the workplace

Migraine in the workplace

Pituitary neuroendocrine tumor: A neuropsychological comparison with intra‐axial tumor

Migraine Pharmacological Treatment and Cognitive Impairment: Risks and Benefits

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