Intergenerational trends in reproduction: Infertility and pregnancy loss

Woolner, Andrea MF.; Bhattacharya, Siladitya

doi:10.1016/j.bpobgyn.2022.102305

Cited by 5 publications

(4 citation statements)

References 76 publications

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“…Couples with unexplained infertility need to discuss their family medical history with their healthcare provider to identify any potential genetic risk factors. For example, if a woman's mother or sister experiences unexplained infertility, it may indicate a genetic predisposition to this condition [82]. Furthermore, a family history of other reproductive disorders, such as endometriosis or polycystic ovary syndrome (PCOS), may also increase the risk of unexplained infertility [20].…”

Section: Family History and Genetic Counselingmentioning

confidence: 99%

Investigating the Genetic Basis of Unexplained Infertility and Potential Chromosomal Abnormalities

Mega Obukohwo,

Abosede Oreoluwa,

Comfort

et al. 2024

OBM Genet

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Infertility affects millions globally, with 10-15% of couples experiencing unexplained cases. Despite advancements in medicine, the cause remains unknown, causing emotional distress. Recent research suggests a genetic basis for this issue. This review aims to provide a better understanding of the underlying genetic factors contributing to unexplained infertility and potentially identify genetic markers that could aid in the diagnosis and treatment of this condition. A literature review was conducted to understand the genetic basis of unexplained infertility. Relevant articles from databases like PubMed and Google Scholar were analyzed, covering topics like genetics, chromosomal abnormalities, genetic markers, and fertility, resulting in 50 articles. The literature review revealed that there is a strong correlation between unexplained infertility and chromosomal abnormalities. Several studies have reported an increased rate of chromosomal abnormalities in couples with unexplained infertility compared to those with normal fertility. Around 10% of couples with unexplained infertility had chromosomal abnormalities, with the most common being translocations. A higher rate of chromosomal abnormalities in couples with unexplained infertility who had a history of recurrent miscarriages. The review reveals a significant genetic component to unexplained infertility, with chromosomal abnormalities in affected couples indicating underlying genetic factors. Further research is needed to identify specific genetic markers for diagnosis and treatment, potentially leading to personalized treatment options. Genetic counseling and testing should be considered for couples with recurrent miscarriages to identify potential abnormalities and provide appropriate support.

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Section: Family History and Genetic Counselingmentioning

confidence: 99%

Investigating the Genetic Basis of Unexplained Infertility and Potential Chromosomal Abnormalities

Mega Obukohwo,

Abosede Oreoluwa,

Comfort

et al. 2024

OBM Genet

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“…Approximately 30−50% of infertility cases are caused by male factors, 5 while the remaining infertility cases are due to female factors; moreover, intergenerational trends in infertility incidence are also observed. 6 Currently, female infertility is diagnosed by the sex hormone test, hysterosalpingography, the ultrasound-based antral follicle count test, and the anti-Mullerian hormone test. 7 These diagnostic tests, however, are required to be performed during the menstrual period of women and have a high cost.…”

Section: Introductionmentioning

confidence: 99%

Plasma Proteomics Analysis of Early Biomarkers for Predicting Female Fecundability: A Nested Case-Control Study

Huang,

Hong,

Zhang

et al. 2024

J. Proteome Res.

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The present study aimed to identify and verify new plasma protein markers to predict the female fecundability level. A nested case-control study was conducted involving couples who participated in the Chinese National Free Preconception Check-up Project. Women who successfully conceive within one year were defined as the high fecundability group, and those unable to conceive were defined as the low fecundability group. In the training cohort, potential protein biomarkers were identified using proteomics technology and were further tested in a validation cohort by the Western blotting assay, enzyme-linked immunosorbent assay, and biochemical tests. Meanwhile, receiver operating characteristic curve analysis were used to evaluate the predictive value. Cox proportional hazard regression analyses were conducted to calculate hazard ratios; restricted cubic spline analysis was used to assess the linear relationship between the the protein level and hazard ratios for fecundability. Pyruvate, a key product of glycolysis, was significantly increased in the high fecundability group (P < 0.01) compared to the low fecundability group, and its area under the curve value was 0.68 (P < 0.05). There was a linear positive dose−response association between the pyruvate level and fecundability possibility (hazard ratios = 1.66, 95% CI: 1.07−2.59, p for trend = 0.025, nonlinearity, p-value = 0.2927).

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“…2 However, female infertility patients generally have a sense of shame and a high level due to the particularity of physiological reasons, which mainly comes from themselves, family, friends, and society, which brings negative effects to patients, such as negative emotion, social isolation, low life satisfaction, and so on. 3,4 The causes of female infertility are complex and diverse, including uterine factors, fallopian tube factors, ovarian factors, and immune factors and endocrine factors, among which fallopian tube factors are the most common cause of female infertility. [5][6][7] It accounts for approximately 30% to 50% of the incidence of female infertility and shows an upward trend year by year.…”

Section: Introductionmentioning

confidence: 99%

“…Among them, female and male factors each account for 30%, male and female common factors account for 10%, and unexplained infertility accounts for approximately 25% 2 . However, female infertility patients generally have a sense of shame and a high level due to the particularity of physiological reasons, which mainly comes from themselves, family, friends, and society, which brings negative effects to patients, such as negative emotion, social isolation, low life satisfaction, and so on 3,4 . The causes of female infertility are complex and diverse, including uterine factors, fallopian tube factors, ovarian factors, and immune factors and endocrine factors, among which fallopian tube factors are the most common cause of female infertility 5–7 .…”

Section: Introductionmentioning

confidence: 99%

Contrast Agent Reflux in Transvaginal 4-D Hysterosalpingo-Contrast Sonography

Yang,

Zhong,

Zhang

et al. 2023

Ultrasound Quarterly

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Transvaginal 4-D hysterosalpingo-contrast sonography (TV 4-D HyCoSy) plays an important role in the detection and diagnosis of clinical female infertility. The purposes of this study were to analyze the influencing factors of TV 4murD HyCoSy complicated with contrast agent reflux and to provide evidence for clinical diagnosis and treatment. Female patients diagnosed as infertility by transvaginal hysterosalpingography from January 2021 to December 2022 were included. The characteristics of patients with and without contrast agent reflux were evaluated. Pearson correlation and logistic regression were conducted to analyze the related factors affecting the occurrence of contrast reflux. A total of 416 patients undergoing TV 4-D HyCoSy were included, and the incidence of contrast agent reflux in patients undergoing TV 4-D HyCoSy was 38.94%. Pearson correlation analysis results indicated that history of uterine cavity operation (r = 0.556), adenomyosis of uterus (r = 0.584), examination on less than 5 days after menstruation (r = 0.602), endometrial thickness (r = 0.566), and endometrial polyps (r = 0.575) are all correlated with contrast agent reflux in patients undergoing 4-D HyCoSy (all P < 0.05). Logistic regression analysis showed that history of uterine cavity operation (odds ratio [OR], 1.109; 95% confidence interval [CI], 1.012–1.872), adenomyosis of uterus (OR, 2.026; 95% CI, 1.864–2.425), examination on less than 5 days after menstruation (OR, 2.465; 95% CI, 2.118–2.851), endometrial thickness less than 6 mm (OR, 2.866; 95% CI, 2.095–2.957), and endometrial polyps (OR, 1.587; 95% CI, 1.137–1.744) were the influencing factors of contrast agent reflux in patients undergoing (all P < 0.05). The incidence of contrast agent reflux in TV 4-D HyCoSy is high, and there are many influencing factors. Clinical medical workers should take early measures based on these influencing factors to reduce the contrast agent reflux.

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Intergenerational trends in reproduction: Infertility and pregnancy loss

Cited by 5 publications

References 76 publications

Investigating the Genetic Basis of Unexplained Infertility and Potential Chromosomal Abnormalities

Investigating the Genetic Basis of Unexplained Infertility and Potential Chromosomal Abnormalities

Plasma Proteomics Analysis of Early Biomarkers for Predicting Female Fecundability: A Nested Case-Control Study

Contrast Agent Reflux in Transvaginal 4-D Hysterosalpingo-Contrast Sonography

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