Investigating the Genetic Basis of Unexplained Infertility and Potential Chromosomal Abnormalities

Abstract

Infertility affects millions globally, with 10-15% of couples experiencing unexplained cases. Despite advancements in medicine, the cause remains unknown, causing emotional distress. Recent research suggests a genetic basis for this issue. This review aims to provide a better understanding of the underlying genetic factors contributing to unexplained infertility and potentially identify genetic markers that could aid in the diagnosis and treatment of this condition. A literature review was conducted to understand the genetic basis of unexplained infertility. Relevant articles from databases like PubMed and Google Scholar were analyzed, covering topics like genetics, chromosomal abnormalities, genetic markers, and fertility, resulting in 50 articles. The literature review revealed that there is a strong correlation between unexplained infertility and chromosomal abnormalities. Several studies have reported an increased rate of chromosomal abnormalities in couples with unexplained infertility compared to those with normal fertility. Around 10% of couples with unexplained infertility had chromosomal abnormalities, with the most common being translocations. A higher rate of chromosomal abnormalities in couples with unexplained infertility who had a history of recurrent miscarriages. The review reveals a significant genetic component to unexplained infertility, with chromosomal abnormalities in affected couples indicating underlying genetic factors. Further research is needed to identify specific genetic markers for diagnosis and treatment, potentially leading to personalized treatment options. Genetic counseling and testing should be considered for couples with recurrent miscarriages to identify potential abnormalities and provide appropriate support.