Intergender Hand Transplant

However, it is unlikely to miss them under magnification in digital phototrichogram (Fig. 1). Trichoscopy allows distinguishing between normal terminal hairs and vellus hairs, which are 0.03 mm or less in thickness and less than 3 mm in length. 16,17 Hence, we conclude that the higher number of hairs counted during the follow-up in our patient reflects HF neogenesis and does not reflect transformation of vellus hair to terminal hair under hormonal influence.

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Immunosuppressive strategies in face and hand transplantation: a comprehensive systematic review of current therapy regimens and outcomes

Huelsboemer,

Boroumand,

Kochen

et al. 2024

Front. Transplant.

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BackgroundRecipients of Vascularized Composite Allotransplants require effective immunosuppressive therapy to prevent graft rejection. This systematic review summarizes the current body of literature on immunosuppressive regimens used in face and hand transplants while summarizing their outcome in terms of rejection, renal failure, and infections.MethodsA systematic search of electronic databases was conducted to identify relevant studies from 1998 until July 1st, 2023. We included all studies that discussed immunosuppressive strategies in face and hand transplant recipients according to PRISMA.ResultsThe standard triple maintenance therapy was mostly adjusted due to nephrotoxicity or high incidence of rejection. The most common alternative treatments utilized were sirolimus (25/91; 27.5%) or everolimus (9/91; 9.9%) following hand- and photophoresis (7/45; 15.6%), sirolimus (5/45; 11.1%) or belatacept (1/45; 2.2%) following face transplantation. Episodes of rejection were reported in 60 (65.9%) of hand- and 33 (73%) of face transplant patients respectively. Graft loss of 12 (13.2%) hand and 4 (8.9%) face transplants was reported. Clinical CMV infection was observed in 6 (6.6%) hand and 7 (15.5%) face transplant recipients.ConclusionsBased on the herein presented data, facial grafts exhibited a heightened incidence of rejection episodes and CMV infections. Facial mucosa adds complexity to the immunological graft composition highlighting the need of individualized immunosuppressive regimens and further research.

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Intergender Hand Transplant

Cited by 3 publications

References 14 publications

Letter to the Editor: Comment on Friji Mt, et al. Intergender Hand Transplant: A Sex Congruent Hand Transformation (Ann Plast Surg. 2021;86:223–225)

Letter to the Editor: Comment on Friji Mt, et al. Intergender Hand Transplant: A Sex Congruent Hand Transformation (Ann Plast Surg. 2021;86:223–225)

Invited Commentary from the Authors of: Friji Mt, et al. Intergender Hand Transplant: A Sex Congruent Hand Transformation

Immunosuppressive strategies in face and hand transplantation: a comprehensive systematic review of current therapy regimens and outcomes

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