Interferon γ release assay for the diagnosis of uveitis associated with tuberculosis: a Bayesian evaluation in the absence of a gold standard

Abstract

The T-SPOT.TB assay is more specific but less sensitive than the TST and should be used in preference to the TST in low-TB-prevalence populations. Used in conjunction, the likelihood of TAU is greatest if the T-SPOT.TB and TST are both positive.

Review of Results of QuantiFERON TB Gold Test in Presumed Ocular Tuberculosis in a South Indian Patient Population

“…Gineys et al 9 reported 44% QFT-G positivity in presumed ocular tuberculosis in a low TB endemic country while Ang et al 10 reported 66% QFT-G positivity in presumed ocular tuberculosis in a moderate TB endemic country. Gineys et al reported encouraging results with ATT in patients with values over 2 IU.…”

Posterior Uveitis

“…Current evidence shows that while TST is more sensitive [ 278 ], QFT and T-SPOT are more specifi c for the diagnosis of presumed ocular tuberculosis ( [ 11 , 12 ], EBM: C, 2+). TST and T-SPOT test should be the investigation of choice in high and low endemic populations, respectively ( [ 12 ], EBM:C, 2+).…”

Discordance of two interferon-γ release assays and tuberculin skin test in patients with uveitis

“…However, the diagnosis of tuberculous uveitis is challenging due to low yield from cultures of intraocular samples given the small sample volumes and low bacterial load 2. As such, tuberculous uveitis is currently diagnosed using a combination of suggestive clinical features (broad-based posterior synechiae, granulomatous inflammation, serpiginious choroiditis, retinal vasculitis) in combination with concomitant evidence of active or latent systemic tuberculosis (TB) 3.…”