Discordance of two interferon-γ release assays and tuberculin skin test in patients with uveitis

Abstract

Discordance of IGRA and TST results is common and requires further study. In our study in patients with uveitis, we found that ethnicity, age, and type of uveitis were some significant factors associated with TST/IGRA discordance, which may need to be taken into consideration when interpreting these results.

Étude observationnelle de l’usage du QuantiFERON® pour le diagnostic de tuberculose oculaire, basée sur 244 tests consécutifs

“…L'IDR est peu contributive dans les pays à large couverture vaccinale [23,27,28], et il existe souvent une discordance entre QTF et IDR, allant de 25 à 49% [29]. Dans notre étude la proportion de QFT positif et d'IDR négative était de 16%.…”

Retina and the tubercle Bacillus: Four decades of our journey and current understanding

“…Similar discordance has been reported in literature. [33] Hence, how should one manage a patient with positive TST and negative IGRA and vice versa? This becomes a clinical dilemma particularly when there are no facilities for undertaking NAAT-based tests and the guidelines on when to perform aqueous and vitreous tap in such patients is not clearly laid out.…”

Cost-effectiveness of alternative strategies for interferon-γ release assays and tuberculin skin test in tuberculous uveitis

“…There is currently no clear consensus on which test to use and the most cost-effective testing algorithm, specifically for the diagnosis of tuberculous uveitis 11. Therefore, in this study we attempted to determine the most cost-effective testing strategy in the context of tuberculous uveitis for our population.…”