2007
DOI: 10.1007/s11064-007-9323-z
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Interferon-γ Promotes Differentiation of Neural Progenitor Cells via the JNK Pathway

Abstract: It has been reported that interferon-gamma (IFN-gamma) facilitates differentiation of PC-12 cells and murine adult neural stem cells. Here we show that IFN-gamma promotes the differentiation of C17.2 neural progenitor cells (NPC) into a neuronal phenotype characterized by neurite outgrowth and the expression of the neuronal marker protein beta-III tubulin. IFN-gamma induced an increase in the activity c-jun N-terminal kinase (JNK) without affecting activities of extracellular signal-regulated kinases (ERKs 1 a… Show more

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Cited by 78 publications
(85 citation statements)
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“…Our results reveal that IFN␥ deficiency leads to increased neuronal production in vitro, with IFN␥ treatment of wild-type cells producing the opposite effect. In contrast, IFN␥ has been reported previously to promote neuronal differentiation of NPs (Wong et al, 2004;Kim et al, 2007;Leipzig et al, 2010), possibly as a result of different assay conditions (e.g., Wong et al exposed dissociated neurosphere cells to IFN␥ throughout differentiation, whereas in our paradigm, the treated NPs differentiated in IFN␥-free medium). Importantly, our in vitro findings were strongly supported by the observation that IFN␥ deficiency results in an increased number of newborn neurons in the olfactory bulb, providing the first evidence that endogenous IFN␥ controls neuronal production.…”
Section: Discussioncontrasting
confidence: 72%
“…Our results reveal that IFN␥ deficiency leads to increased neuronal production in vitro, with IFN␥ treatment of wild-type cells producing the opposite effect. In contrast, IFN␥ has been reported previously to promote neuronal differentiation of NPs (Wong et al, 2004;Kim et al, 2007;Leipzig et al, 2010), possibly as a result of different assay conditions (e.g., Wong et al exposed dissociated neurosphere cells to IFN␥ throughout differentiation, whereas in our paradigm, the treated NPs differentiated in IFN␥-free medium). Importantly, our in vitro findings were strongly supported by the observation that IFN␥ deficiency results in an increased number of newborn neurons in the olfactory bulb, providing the first evidence that endogenous IFN␥ controls neuronal production.…”
Section: Discussioncontrasting
confidence: 72%
“…[42][43][44] Although untested, there is a possibility that IFN␥ antagonizes these latter pathways or acts via a completely unrelated mechanism to suppress tau hyperphosphorylation. Signs of marked neurogenesis were also evident in IFN␥-expressing 3ϫTg-AD mice, a finding confirmed in a different murine AD model in the recent report from Baron et al 36 IFN␥ has been shown to promote neuronal differentiation in vitro, 45,46 neuronal plasticity, and receptor clustering. 47 Moreover, human neural stem/progenitor cell cultures express the cognate receptors for IFN␥, termed IFN-␥-R␣ and IFN-␥-R␤, and are driven toward a neuronal fate when cultured in the presence of IFN␥.…”
Section: Brdu Incorporationsupporting
confidence: 63%
“…IFNγ increases p11 through a direct interaction with IFNγ binding sites on the p11 promoter (22). IFNγ increases neurite outgrowth (23), promotes neuronal differentiation (24), and enhances neurogenesis (25), all of which are consistent with antidepressant-like activity (26). However, it has been suggested that IFNγ mediates depression-behaviors caused by immune activation (27).…”
Section: Discussionmentioning
confidence: 99%