Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1) as a Prognostic Marker for Local Control in T1-2 N0 Breast Cancer Treated with Breast-Conserving Surgery and Radiation Therapy (BCS + RT)

Danish, H.; Goyal, Sharad; Taunk, Neil K.; Wu, Hao; Moran, Meena S.; Haffty, Bruce G.

doi:10.1111/tbj.12097

Cited by 22 publications

(13 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IFIT1-positive cells were more frequent after infection (Figures 5C and 5F), but highly upregulated in SIV, in cells localized in the perivascular domain (Figure 5I). This finding is contrasting with other findings in the literature, showing that IFIT1 is upregulated in HIV+ elite controllers(Krishnan et al 2014), or in cancer patients, where high levels of IFIT1 correlate with improvement following treatment(Danish et al 2013). On the other hand, it has been shown that a high expression of IFIT1 in areas of the brain is a marker of aberrant IFN response in aging(Baruch et al 2014).…”

Section: Resultscontrasting

confidence: 99%

Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain

Bortell

Basova

Najera

et al. 2017

J Neuroimmune Pharmacol

View full text Add to dashboard Cite

Microglia and macrophages are the main non-neuronal subsets of myeloid origin in the brain, and are critical regulators in neurodegenerative disorders, where inflammation is a key factor. Since HIV infection results in neurological perturbations that are similar to those in aging, we examined microglial and infiltrating myeloid subsets in the search for changes that might resemble the ones in aging. For that, we used the SIV infection in rhesus macaques to model neuroAIDS. We found that Sirt-1, a molecule that impacts survival and health in many models, was decreased in cell preparations containing a majority of microglia and myeloid cells from the brain of infected macaques. The role of Sirt-1 in neuroAIDS is unknown. We hypothesized that Sirt-1 silencing functions are affected by SIV. Mapping of Sirt-1 binding patterns to chromatin revealed that the number of Sirt-1-bound genes was 29.6% increased in myeloid cells from infected animals with mild or no detectable neuropathology, but 51% was decreased in severe neuropathology, compared to controls. Importantly, Sirt-1-bound genes in controls largely participate in neuroinflammation. Promoters of type I IFN pathway genes IRF7, IRF1, IFIT1, and AIF1, showed Sirt-1 binding in controls, which was consistently lost after infection, together with higher transcription. Loss of Sirt-1 binding was also found in brains from old uninfected animals, suggesting a common regulation. The role of Sirt-1 in regulating these inflammatory markers was confirmed in two different in vitro models, where Sirt-1 blockage modulated IRF7, IRF1 and AIF1 levels both in human macrophage cell lines and in human blood-derived monocytes from various normal donors, stimulated with a TLR9 agonist. Our data suggests that Sirt-1-inflammatory gene silencing is disturbed by SIV infection, resembling aging in brains. These findings may impact our knowledge on the contribution of myeloid subsets to the neurological consequences of HIV infection, aggravated and overlapping with the aging process.

show abstract

Section: Resultscontrasting

confidence: 99%

Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain

Bortell

Basova

Najera

et al. 2017

J Neuroimmune Pharmacol

View full text Add to dashboard Cite

show abstract

“…The antiviral functions of human IFIT proteins have been extensively demonstrated in many research studies Sen, 2011, 2015;Diamond and Farzan, 2013). Recent studies have implicated IFIT proteins as prognostic markers to determine the clinical outcome of many cancers, such as glioblastoma, hepatocellular carcinoma, breast cancer and pancreatic cancer (Danish et al, 2013;Zhang et al, 2016;Yang et al, 2017;Zhao et al, 2017). During the past several years, we explored the biological and clinical functions of IFIT proteins in oral squamous cell carcinoma (OSCC) (Blot et al, 1988;Lai et al, 2008Lai et al, , 2013Pidugu et al, 2019b).…”

Section: Introductionmentioning

confidence: 99%

Emerging Functions of Human IFIT Proteins in Cancer

Pidugu

et al. 2019

Front. Mol. Biosci.

109

105

View full text Add to dashboard Cite

Interferon-induced protein with tetratricopeptide repeats (IFIT) genes are prominent interferon-stimulated genes (ISGs). The human IFIT gene family consists of four genes named IFIT1, IFIT2, IFIT3, and IFIT5. The expression of IFIT genes is very low in most cell types, whereas their expression is greatly enhanced by interferon treatment, viral infection, and pathogen-associated molecular patterns (PAMPs). The proteins encoded by IFIT genes have multiple tetratricopeptide repeat (TPR) motifs. IFIT proteins do not have any known enzymatic roles. However, they execute a variety of cellular functions by mediating protein-protein interactions and forming multiprotein complexes with cellular and viral proteins through their multiple TPR motifs. The versatile tertiary structure of TPR motifs in IFIT proteins enables them to be involved in distinct biological functions, including host innate immunity, antiviral immune response, virus-induced translation initiation, replication, double-stranded RNA signaling, and PAMP recognition. The current understanding of the IFIT proteins and their role in cellular signaling mechanisms is limited to the antiviral immune response and innate immunity. However, recent studies on IFIT protein functions and their involvement in various molecular signaling mechanisms have implicated them in cancer progression and metastasis. In this article, we focused on critical molecular, biological and oncogenic functions of human IFIT proteins by reviewing their prognostic significance in health and cancer. Research suggests that IFIT proteins could be novel therapeutic targets for cancer therapy.

show abstract

“…Pei et al reported the role of IFIT1 in the limitation of hepatitis B virus replication, while Danish et al introduced IFIT1 as a prognostic marker for local control in T1-2 N0 breast cancer treated with breast-conserving surgery and radiation therapy. 25,26 Like the other central DEGs, IFIT1 is connected to most of the biological processes (see Figure 4).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Cytokine-Mediated Signaling Pathway Dysregulation in Arm Skin After CO2 Laser Therapy

et al. 2019

View full text Add to dashboard Cite

Introduction: Laser therapy is known as an efficient approach in dermatology surgery. CO2 laser therapy is a gold standard treatment in skin surgery. This study aimed to evaluate the interferons change after CO2 laser surgery Methods: Significant differentially-expressed genes (DEGs) of arm skin after 7 days of treatment by the CO2 laser relative to the controls are downloaded from Gene Expression Omnibus (GEO) and are included in the protein-protein interaction network via a STRING database (an application of Cytoscape software). The central DEGs were identified and enriched via gene ontology by using Clue GO software. Results: A network including 78 DEGs and 100 neighbors was constructed and STAT1, MX1, ISG15, OAS1, IFIT1, IRF8, OASL, OAS2, and RSAD2 as hubs and STAT1, PTPRC, MX1, IRF8, ISG15, IL6, RORC, SAMSN1, and IFIT1 as bottlenecks were introduced. The cytokine-mediated signaling pathway, interferon gamma signaling, hepatitis C, interferon alpha/beta signaling, and the type I interferon signaling pathway were identified as 5 clusters of biological terms which are related to the central nodes. Conclusion: It can be concluded that the cytokine-mediated signaling pathway is the major pathway that is dysregulated after laser application in the treated skin.

show abstract

Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1) as a Prognostic Marker for Local Control in T1-2 N0 Breast Cancer Treated with Breast-Conserving Surgery and Radiation Therapy (BCS + RT)

Cited by 22 publications

References 27 publications

Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain

Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain

Emerging Functions of Human IFIT Proteins in Cancer

Assessment of Cytokine-Mediated Signaling Pathway Dysregulation in Arm Skin After CO2 Laser Therapy

Contact Info

Product

Resources

About