Interferon-Gamma Expression by Intraepithelial Lymphocytes Results in a Loss of Epithelial Barrier Function in a Mouse Model of Total Parenteral Nutrition

Abstract

IEL cytokine expression changes significantly with TPN administration. The partial correction with IFN-gamma knockout mice suggests that an upregulation of IFN-gamma expression is one mechanism responsible for the loss of the epithelial barrier associated with TPN.

Effects of Adding Butyric Acid to PN on Gut‐Associated Lymphoid Tissue and Mucosal Immunoglobulin A Levels

“…33 Another group reported a PN-related intestinal IFN-γ increase in C57BL/6J mice. 34 Taken together, these reports suggest an imbalance in the intestinal cytokine milieu to be a very important mechanism for PN-induced reduction of intestinal IgA production. Of interest, butyric acid has been identified as a histone deacetylase (HDAC) inhibitor 17,35 and in vitro inhibition of HDAC in T lymphocytes reportedly suppressed IFN-γ production.…”

Poor oral nutrition after allogeneic stem cell transplantation correlates significantly with severe graft-versus-host disease

“…20 Parenteral nutrition may also result in lower levels of IL-4 and IL-10 6 and increased expression of interferon-g (IFNg). 22 IL-4 and IL-10 belong to the Th2 response, which may play an important role in the regulation of GVHD. 23 Interferon-g is a crucial cytokine in the second phase of acute GVHD, the activation of donor T cells.…”

Intestinal Intraepithelial Lymphocyte γδ-T Cell-Derived Keratinocyte Growth Factor Modulates Epithelial Growth in the Mouse

“…It has been previously shown that administration of TPN can lead to a number of alterations within the immune system of the small bowel mucosa. Among these changes is an increased expression of IFN-␥ and a loss of cells in the gutassociated lymphoid tissue (22,23,45). IELs eliminate infected and senescent cells through a combination of cytotoxicity, and via IFN-␥ and TNF-␣ release (46).…”