Interferon Gamma-Cytokine With Antiviral, Immunomodulatory and Antitumor Action

Сологуб, Т. В.; Tsvetkov, V. V; Deeva, E. G.

doi:10.17816/pavlovj2014356-60

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…The efficacy of the antimicrobial action of the drug is increased by the immunomodulatory effect on the body, caused by recombinant porcine IFN-α and IFN-γ that by increasing the activity of neutrophils, monocytes/macrophages regulate the BIO Web of Conferences 36, 06010 (2021) https://doi.org/10.1051/bioconf/20213606010 FSRAABA 2021 migration of phagocytes into the inflammatory focus, enhance the cytotoxic properties of macrophages, death and intracellular bacteria [28]. IFN-α exhibits immunomodulatory properties, increasing the activity of natural killers, T-helpers, phagocytes, the intensity of differentiation of B-lymphocytes [29], as well as the antibacterial activity of macrophages [30]. In addition, the bacteriostatic effect of IFN-α is due to the disturbance of bioenergetic processes in bacteria (due to depletion of tryptophan), and the mediated bactericidal effect is due to the generation of nitric oxide and reactive oxygen species in macrophages [30,31].…”

Section: Resultsmentioning

confidence: 99%

“…In addition, the bacteriostatic effect of IFN-α is due to the disturbance of bioenergetic processes in bacteria (due to depletion of tryptophan), and the mediated bactericidal effect is due to the generation of nitric oxide and reactive oxygen species in macrophages [30,31]. IFN-γ, being the most important anti-inflammatory cytokine, has a pronounced immunomodulatory effect, activates the effector functions of macrophages, cytotoxic Tlymphocytes, natural killer cells, prostaglandin and corticosteroid systems, contributing to the effective elimination of the infectious agent [29,32].…”

Section: Resultsmentioning

confidence: 99%

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Therapeutic efficacy of a complex drug based on interferons for Actinobacillus pleuropneumonia in piglets

et al. 2021

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The article presents the results of studying the therapeutic efficacy of the complex drug tsipropig based on recombinant porcine interferons for Actinobacillus pleuropneumonia of piglets at an industrial pig-breeding complex and its effect on nonspecific immunity. It has been found that the drug has pronounced therapeutic properties and an immunomodulatory effect due to the presence of the fluoroquinolone antibiotic ciprofloxacin in the composition of tsipropig, the immunocorrective activity of its constituent recombinant porcine interferons alpha and gamma and vitamins E and A possessing antioxidant properties.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Therapeutic efficacy of a complex drug based on interferons for Actinobacillus pleuropneumonia in piglets

et al. 2021

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“…The positive effect of biferon-C on cellular nonspecific and adaptive immunity in piglets in case of specific prevention of circovirosis and mycoplasmosis is due to the presence of recombinant porcine interferons -alpha and -gamma in its composition. The immunomodulatory effect of interferons lies in their ability to regulate the interaction of cells involved in the immune response [34]. The latter carry out a rapid induction of the endogenous cytokine system.…”

Section: Resultsmentioning

confidence: 99%

“…The latter carry out a rapid induction of the endogenous cytokine system. The most pronounced immunomodulatory properties are possessed by endogenous interferon-gamma, which is a key cellular cytokine and an inhibitor of the humoral adaptive immune response, activates Th1 cells, NK cells, macrophages, cytotoxic T lymphocytes, and increases the organism's nonspecific resistance [34,35].…”

Section: Resultsmentioning

confidence: 99%

Correction of cellular immunity with biferon-C in piglets in case of specific prevention of circovirosis and mycoplasmosis

2020

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The results of studying the effect of biferon-C containing recombinant porcine interferons -alpha and -gamma on cellular nonspecific and adaptive immunity in piglets in case of specific prevention of circovirosis and mycoplasmosis are presented. The corrective effect of the drug on cellular immunity was stated, manifested by an increase in the absorption and functional and metabolic activity of phagocytes, the relative and absolute number of T- and B-lymphocytes, T-cells with helper activity and a lower formation of the level of T-suppressors, an increase in the T-helpers/T-suppressors ratio.

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Immunological features of allergic rhinitis in combination with chronic rhinosinusitis of bacterial etiology

Kulikova¹,

Orlova²,

Baranova³

et al. 2022

Med. immunol.

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Rhinitis is a socially significant and widespread disease. Often, various forms of rhinitis are combined, and thus cause severe clinical manifestations, insufficient effectiveness of drug treatment, as well as difficulties in differential diagnosis. It is known that a significant number of patients have a combination of allergic rhinitis (AR) with chronic rhinosinusitis of bacterial etiology. This condition is based on a chronic multifactorial inflammatory process of the nasal mucosa, which determines the steady progression of the disease. Of interest is the study of a number of allergo-immunological parameters in nasal secretions in order to assess local inflammation and changes in mucosal immunity in allergic rhinitis in combination with chronic rhinosinusitis of bacterial etiology (AR with HRSBE). Mucosal immunity and biological mediators determine local inflammation and pathophysiological response to etiological factors in the immunopathogenesis of AR with CRSBE. The work carried out the determination of the level of cytokines: IL-4, IL-10, TGF-â1, IFNã spontaneous and induced; immunoglobulins: IgA, IgM, IgG, sIgA in nasal secretions; leukotrienes: LT C4/ D4/E4 and LTB4 in plasma and total IgE in serum in patients with AR with moderate-severity HRSBE without exacerbation. It has been shown that the leading role in the formation of the inflammatory process in AR with CRSBE belongs to cytokines: IL-4, IL-10, TGF-â; immunoglobulins: IgM, sIgA; leukotrienes: LT C4/D4/E4 and LTB4 and total IgE. Induced cytokine production largely reflects the reserve capabilities of immunocompetent cells in response to the action of a pathogenic factor. The results obtained are associated with the persistent course of allergic and infectious inflammation and the progression of the disease. Thus, cytokines: IL-4, IL-10, TGF-â1; immunoglobulins: IgM, sIgA, IgE total and LT C4/D4/E4 and LTB4 make a significant contribution to pathogenetic mechanisms, determining the clinical course of AR with CRSBE, and can serve as biological markers of the activity of the pathological process. Undoubtedly, the immune mechanisms in the combined pathological inflammatory reaction from the mucosa in AR with HRSBE are complex and multifaceted. A personalized approach to the treatment of patients with AR with CRSBE is determined by the severity and intensity of the inflammatory reaction, as well as mucosal mucosal immunity disorders. The study of the role and significance of the production of leading cytokines, immunoglobulins in nasal secretions, as well as leukotrienes and total IgE in the blood will help the doctor in determining the tactics and duration of pharmacotherapy.

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Interferon Gamma-Cytokine With Antiviral, Immunomodulatory and Antitumor Action

Cited by 7 publications

References 5 publications

Therapeutic efficacy of a complex drug based on interferons for Actinobacillus pleuropneumonia in piglets

Therapeutic efficacy of a complex drug based on interferons for Actinobacillus pleuropneumonia in piglets

Correction of cellular immunity with biferon-C in piglets in case of specific prevention of circovirosis and mycoplasmosis

Immunological features of allergic rhinitis in combination with chronic rhinosinusitis of bacterial etiology

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