Interferon‐alpha therapy in children with malignant diseases: Clinical experience in twenty‐four patients treated in a single pediatric oncology unit

Kiss, Csongor; Kiss, M.; Szegedi, István; Arvai, Krisztina; Tóth, Judit; Oláh, Éva

doi:10.1002/mpo.10088

Cited by 7 publications

(5 citation statements)

References 15 publications

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“…During this period, 218 children received active anticancer treatment according to current Hungarian Pediatric Oncology-Hematology Group guidelines. The management of children with cancer was strictly uniform in every Hungarian pediatric cancer treatment center [23]. Patients were followed for five years.…”

Section: Patientsmentioning

confidence: 99%

Prevalence of Undernutrition and Effect of Body Weight Loss on Survival among Pediatric Cancer Patients in Northeastern Hungary

Kadenczki

Nagy

Kiss

2021

IJERPH

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Undernutrition is a prevalent condition in pediatric malignancy patients leading to unfavorable outcomes. The aim of this retrospective study was to determine the nutritional status and rate of undernutrition in 174 Hungarian pediatric patients with malignancies and the impact on 5-year survival based on anthropometric measurements. At the time of diagnosis, 5.0%, 4.6%, and 4.0% of patients were undernourished as determined by body weight (BW), weight-for-height (WFH), and body mass index (BMI) Z-score, respectively. The rate of undernutrition was 30.5% using ideal body weight percent (IBW%). Undernutrition at the time of diagnosis worsened the five-year overall survival only in solid tumor patients as defined by BMI Z-score and IBW%. Furthermore, 26.5% of patients became undernourished based on IBW% during the treatment period. Deterioration of nutritional status during treatment unfavorably influenced overall survival in both hematological and solid tumor subsets. Abnormal BW, WFH, and BMI Z-score were associated with poor prognosis in the hematologic group. The mortality risk was higher among hematologic patients with weight loss exceeding 20%. In conclusion, IBW% seems to be the most sensitive parameter to estimate undernutrition. Furthermore, BMI Z-score in both groups and severe weight loss in the hematological group may influence clinical outcome and play a role in prognosis assessment.

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Section: Patientsmentioning

confidence: 99%

Prevalence of Undernutrition and Effect of Body Weight Loss on Survival among Pediatric Cancer Patients in Northeastern Hungary

Kadenczki

Nagy

Kiss

2021

IJERPH

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“…Radiotherapy is mostly used in palliation. Experimental data and clinical observations obtained in adult patients as well as in certain childhood malignancies suggest a potential role for INF in some cancers refractory to conventional treatment 17. Uchiyama et al 18 used INF‐α in advanced childhood RCC after surgery with promising results.…”

Section: Discussionmentioning

confidence: 99%

Whole body hyperthermia in adjuvant therapy of children with renal cell carcinoma

Zhavrid¹,

Потапнев

2005

Pediatric Blood & Cancer

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Whole body hyperthermia (WBH) in combination with chemotherapy has been proven to be effective in some patients with advanced malignancies. However, only limited experience exists regarding the application of WBH with chemotherapy in children. We present the results of applying WBH and chemotherapy in five children with advanced renal cell carcinoma (RCC). WBH (3 hr, 41.8-42.5 degrees C) combined with doxorubicin (50 mg/m2) and interferon-alpha (3 MU/m2) were applied to patients after nephrectomy and lymph node dissection. Each patient received three to eight courses of treatment three times weekly. All children tolerated the combined therapy well without complications. Follow-up of 7-68 months (median: 22 months) showed no tumor progression in patients with locoregional (n = 3) and metastatic (n = 2) disease. WBH with moderate dose doxorubicin and INF-alpha might be a feasible treatment option in childhood RCC.

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“…The effect of cytokine preparations (Interleukin 2/IL 2/Proleukin and interferon alpha/IFN α 2b/ Intron A) on immune cell subpopulations has been studied in the children suffering with advanced malignan cies during intensive chemotherapy cycles combined with whole body hyperthermia (thermochemotherapy В клинической онкологии продолжается интен сивный поиск новых терапевтических подходов для повышения эффективности лечения больных с да леко зашедшими и рецидивными формами злокаче ственных опухолей. Большие надежды возлагают ся в этом плане на применение биотерапии, в том числе гипертермии [4,5,7,8]. Влияние гипертер мии на трансмембранный перенос и метаболизм может привести к преодолению лекарственной ус тойчивости и повышению иммуногенности опухо ли [6].…”

Section: Ismail Zade Rs Belevtsev MV Potapnev Mp Savitskiy Vunclassified

Interleukin-2 – And Interferon-Alpha- Induced Changes of Peripheral Blood Lymphocyte Subpopulations in Children With Advanced Malignancies, Treated With Chemotherapy and Whole Body Hyperthermia

Belevtsev¹,

Потапнев²,

Савицкий³

et al. 2014

Med. immunol.

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Резюме. Изучено влияние препаратов цитокинов интерлейкина 2 (Ронколейкин) и интерферона α 2b (Интрон А) на субпопуляционный состав лимфоцитов периферической крови у детей с распространенными формами злокачественных опухолей на этапах интенсивной химиотерапии с сеансами общей гипертермии. Показано, что применение Интрона А на фоне термохимиотерапии способствует восстановлению абсолют ного числа лимфоцитов периферической крови без существенного влияния на их субпопуляционный со став. Применение Ронколейкина сопровождалось более выраженной лимфопенией и повышением содержа ния активированных (CD25 + , HLA DR + ) T клеток по сравнению с использованием Интрона А. У больных, принимавших Ронколейкин или Интрон А, отмечено разнонаправленное изменение соотношения CD4 + / CD8 + Т клеток в сторону увеличения числа CD4 + Т клеток под действием Ронколейкина. Сделан вывод о разных механизмах иммуномодулирующего действия препаратов интерлейкина 2 и интерферона α 2b у он кологических больных, получающих комплексную химиобиотерапию с общей гипертермией.Ключевые слова: интерлейкин 2, интерферон альфа, общая гипертермия, опухоли у детей. Ismail zade R.S., Belevtsev M.V., Potapnev M.P., Savitskiy V.P., Zhavrid E.A., Buglova S.E. INTERLEUKIN 2 -AND INTERFERON ALPHA INDUCED CHANGES OF PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS IN CHILDREN WITH ADVANCED MALIGNANCIES, TREATED WITH CHEMOTHERAPY AND WHOLE BODY HYPERTHERMIAAbstract. The effect of cytokine preparations (Interleukin 2/IL 2/Proleukin and interferon alpha/IFN α 2b/ Intron A) on immune cell subpopulations has been studied in the children suffering with advanced malignan cies during intensive chemotherapy cycles combined with whole body hyperthermia (thermochemotherapy

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Interferon‐alpha therapy in children with malignant diseases: Clinical experience in twenty‐four patients treated in a single pediatric oncology unit

Cited by 7 publications

References 15 publications

Prevalence of Undernutrition and Effect of Body Weight Loss on Survival among Pediatric Cancer Patients in Northeastern Hungary

Prevalence of Undernutrition and Effect of Body Weight Loss on Survival among Pediatric Cancer Patients in Northeastern Hungary

Whole body hyperthermia in adjuvant therapy of children with renal cell carcinoma

Interleukin-2 – And Interferon-Alpha- Induced Changes of Peripheral Blood Lymphocyte Subpopulations in Children With Advanced Malignancies, Treated With Chemotherapy and Whole Body Hyperthermia

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