Interference of tannic acid on the genotoxicity of mitomycin C, methylmethanesulfonate, and nitrogen mustard in somatic cells ofDrosophila melanogaster

Lehmann, Maurı́cio; Gräf, Ulrich; Reguly, Maria Luı́za; Andrade, Heloı́sa Helena Rodrigues de

doi:10.1002/1098-2280(2000)36:3<195::aid-em2>3.0.co;2-b

Cited by 30 publications

(20 citation statements)

References 31 publications

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“…According to Lehmann et al (2000), with the increase in the consumption of foods containing chemopreventive components, it may be possible to improve protection against the damage caused by mutagenic and carcinogenic compounds. This has led to an increased interest in the possible antimutagenic effects of natural products or chemical compounds and, consequently, an increase in studies in this area.…”

Section: Discussionmentioning

confidence: 99%

Trans-resveratrol concentrations and antimutagenic potential of juice from the grape cultivars Vênus, BRS Violeta and Isabel

Polonio¹,

Rocha²,

Clemente³

2014

Genet. Mol. Res.

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ABSTRACT. Grape juice, in addition to being an energetic food, due to its high sugar content, has several compounds that can prevent or treat various types of diseases. Resveratrol is a compound present in grapes that has attracted a lot of interest; in addition to preventing cardiovascular disease linked to lipid metabolism, it has chemopreventive and chemotherapeutic activities. We evaluated the antimutagenic activity and determined the trans-resveratrol content in grape juice from the varieties Vênus, BRS Violeta and Isabel. The grape juices from the three cultivars and the resveratrol solution were tested in the methG1 system in Aspergillus nidulans. The conidia from the biA1methG1 strain were treated for 4 h in 10% grape juice (v/v). After washing, the conidia were placed in selective media to analyze survival and mutations. The standard resveratrol solution and the grape juice of the cultivar Isabel, both with a trans-resveratrol content of 1 mg/ mL, presented antimutagenic potential in this test system because the frequency of mutation of the treatments was significantly lower than the frequency of spontaneous mutation. However, grape juice from Evaluation of antimutagenicity of grape juice the varieties Vênus and BRS Violeta, both with a lower quantity of trans-resveratrol, gave weak antimutagenic activity in this test system because the frequency of mutation of the treatments was significantly higher than the frequency of spontaneous mutation.

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Section: Discussionmentioning

confidence: 99%

Trans-resveratrol concentrations and antimutagenic potential of juice from the grape cultivars Vênus, BRS Violeta and Isabel

Polonio¹,

Rocha²,

Clemente³

2014

Genet. Mol. Res.

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“…However, the frequencies of spontaneous spots normally observed in HB crosses are usually slightly higher than those observed in the ST cross (Graf and van Schaik, 1992;Lehmann et al, 2000;Cunha et al, 2001). Compared to the negative control group, urethane induced a statistically significant number of small single spots and large single spots in the ST cross and in all three categories of spots with the HB cross and demonstrated a high bioactivation effect, with 2.4 spots per fly in the ST cross vs. 10.2 spots per fly in the HB cross.…”

Section: Somatic Mutation and Recombination Test (Smart)mentioning

confidence: 99%

Antigenotoxic effects of Mandevilla velutina (Gentianales, Apocynaceae) crude extract on cyclophosphamide-induced micronuclei in Swiss mice and urethane-induced somatic mutation and recombination in Drosophila melanogaster

Silva

Sousa

Gräf³

et al. 2008

Genet. Mol. Biol.

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A Mandevilla velutina crude extract was investigated using the mouse micronucleus test (MNT) and the Drosophila melanogaster somatic mutation and recombination test (SMART) using standard (ST) and high bioactivation (HB) crosses. The MNT used 10 mg, 20 mg or 40 mg per 100 g of body weight (bw) of extract with and without 0.2 mg per 100 g bw peritoneal cyclophosphamide. There was no genotoxicity in the negative control or extract only groups and, compared to the cyclophosphamide control, there was a significant reduction in micronucleated polychromatic erythrocytes in all the groups given extract plus cyclophosphamide. For SMART larvae were fed 5 or 10 mg mL -1 of extract for seven days with and without 0.89 mg mL -1 of urethane given on day seven. The ST and HB flies showed no significant differences in spots between the negative control and the extract only groups. The number of urethane-induced spots was reduced by the highest concentration of extract for the ST flies and by both concentrations of extract for the HB flies. The results suggest that M. velutina extract is not genotoxic but is antigenotoxic.

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“…However, most reports have focused on individual agents, or on limited sets of chemical analogues, whereas only a few studies have been devoted to hormesis-related effects of complex or model mixtures (Pagano et al 1986;Kaur et al 2000;Lehmann et al 2000;Pautou et al 2000;Backhaus et al 2004;Koshy et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Complex Mixture-Associated Hormesis and Toxicity: The Case of Leather Tanning Industry

et al. 2008

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h A series of studies investigated the toxicities of tannery-derived complex mixtures, i.e. vegetable tannin (VT) from Acacia sp. or phenol-based synthetic tannin (ST), and wastewater from tannin-based vs. chromium-based tanneries. Toxicity was evaluated by multiple bioassays including developmental defects and loss of fertilization rate in sea urchin embryos and sperm (Paracentrotus lividus and Sphaerechinus granularis), and algal growth inhibition (Dunaliella tertiolecta and Selenastrum capricornutum). Both VT and ST water extracts resulted in hormetic effects at concentrations ranging 0.1 to 0.3%, and toxicity at levels ≥1%, both in sea urchin embryo and sperm, and in algal growth bioassays. When comparing tannin-based tannery wastewater (TTW) vs. chromium-based tannery effluent (CTE), a hormesis to toxicity trend was observed for TTW both in terms of developmental and fertilization toxicity in sea urchins, and in algal growth inhibition, with hormetic effects at 0.1 to 0.2% TTW, and toxicity at TTW levels ≥1%. Unlike TTW, CTE showed a monotonic toxicity increase from the lowest tested level (0.1%) and CTE toxicity at higher levels was significantly more severe than TTW-induced toxicity. The results support the view that leather production utilizing tannins might be regarded as a more environmentally friendly procedure than chromium-based tanning process.

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Interference of tannic acid on the genotoxicity of mitomycin C, methylmethanesulfonate, and nitrogen mustard in somatic cells ofDrosophila melanogaster

Cited by 30 publications

References 31 publications

Trans-resveratrol concentrations and antimutagenic potential of juice from the grape cultivars Vênus, BRS Violeta and Isabel

Trans-resveratrol concentrations and antimutagenic potential of juice from the grape cultivars Vênus, BRS Violeta and Isabel

Antigenotoxic effects of Mandevilla velutina (Gentianales, Apocynaceae) crude extract on cyclophosphamide-induced micronuclei in Swiss mice and urethane-induced somatic mutation and recombination in Drosophila melanogaster

Complex Mixture-Associated Hormesis and Toxicity: The Case of Leather Tanning Industry

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