Interference of oral immunization with the intestinal absorption of heterologous albumin

André, C.; Lambert, Reginald M.; Bazin, Hervé; Heremans, J. F.

doi:10.1002/eji.1830041013

Cited by 96 publications

(33 citation statements)

References 14 publications

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“…1,6.1 Some strains of intestinal bacteria, particularly gram-negative bacteria which contain LPS, increase duodenal IgA plasmocytes which secrete IgA into the lumen. '-' However there are still no studies to show whether bifidobacteria, which are the predominant component of the intestinal flora of infants, and gram-positive bacteria that do not contain LPS,8 will induce IgA antibody.…”

Section: Discussionmentioning

confidence: 99%

Detection ofBifidobacteriumStrains that Induce Large Quantities of IgA

Yasui

Nagaoka

Mike

et al. 1992

Microbial Ecology in Health and Disease

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An in vitro screening test using the murine Peyer's patch cell culture method was developed for detection of bifidobacteria which induce large quantities of IgA. Bifidobacteria grown for 48 h were added at a dose corresponding to an absorbance value of 0.275 at 660 nm to BALB/c mouse Peyer's patch cells, and 7 days later the quantities of IgA antibody in the culture supernatants were measured by an ELISA method. With this screening test, three strains of bifidobacteria capable of inducing large quantities of' IgA were selected from 120 strains isolated from human faeces and identified as BiJdobacteriurn breve (two strains) and B. longurn (one strain). When one of the three strains (B. breve YIT 4064) was administered orally along with cholera toxin (CT) into mice, the amount of anti-CT IgA antibody in faeces and anti-CT IgA antibody production and proliferation in Peyer's patch cells tended to be greater and were significantly greater, respectively, than after administration of only C T or CT and B. breve Ka-6, which did not induce IgA.

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Section: Discussionmentioning

confidence: 99%

Detection ofBifidobacteriumStrains that Induce Large Quantities of IgA

Yasui

Nagaoka

Mike

et al. 1992

Microbial Ecology in Health and Disease

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“…Secretory immunity is the basis for specific protection at the mucosal level, where IgA is the main immunoglobulin. Mucosal IgA prevents the adhesion of bacteria or viruses, and reduces the absorption of food antigens in the intestine (25)(26)(27). Yasui et al (28) reported that certain lactic acid bacteria which generate large quantities of IgA could prevent infections of the rotavirus.…”

Section: Discussionmentioning

confidence: 99%

Stimulatory effect of Shoyu polysaccharides from soy sauce on the intestinal immune system

Matsushita¹,

Kobayashi²,

Tsukiyama³

et al. 1998

Int J Mol Med

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Abstract. Soy sauce (Shoyu) is a traditional Japanese fermented seasoning and is available worldwide. We investigated the effect of Shoyu polysaccharides (SPS) prepared from soy sauce on the intestinal immune system of mice. SPS enhanced the production of immunoglobulin A (IgA) from Peyer's patch cells in vitro, and its oral administration to 7-week-old male BALB/c mice for 2 weeks at a dose of 1.5 mg per day significantly (p<0.01) increased the concentration of IgA in the intestine as compared to control mice. Furthermore, experiments on the intestinal transport of SPS in vitro using the human intestinal epithelial cell line Caco-2 confirmed the permeation of uronic acid to be timedependent. In conclusion, SPS of soy sauce enhanced the production of IgA in vitro and in vivo, and the digested SPS might cross the enterocytic monolayer. Thus, soy sauce is a potentially promising food for enhancing host defenses.

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“…After rats were immunized with an oral administration of the antigen or with an emulsion of FREUND'S complete adjuvand and the antigen, it is widely accepted that there will be a decreased amount of absorbed intact antigen by the intestines. This finding suggests that immunocomplexes formed in the lumen seem to prevent absorption of the antigen [22,26,27].…”

Section: Discussionmentioning

confidence: 99%

Uptake of BSA and production of the antibody against BSA in rat intestine.

Igarashi

Fujiki

Takebe

et al. 1985

The Journal of Nihon University School of Dentistry

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After rats were orally administrated with bovine serum albumin (BSA) for 14, 30 and 90 days, we examined the localization of the absorbed intact BSA immunohistologically and the production of the antibody against the absorbed BSA in the intestine.Light microscopical sections with hematoxylin-eosin (H-E) stain, as compared with normal intestine, revealed an increased number of disrupted goblet cells and extended macrophages in the lamina propria.By the immunofluorescent method, intact BSA absorbed by the intestine was found in macrophages, intestinal columnar cells, the lateral extracellular spaces between the columnar cells, goblet cells and mucous materials in the lumen.The cytoplasm of the plasma, macrophages and intestinal columnar cells showed the antibody against BSA.These findings suggest that orally administrated BSA is absorbed in macromolecular form by the intestine and the antibody against BSA produced in the plasma cells is secreted in the lumen as secretory IgA (SIgA). And consequently, immunocomplexes are formed in the lumen, and there is an increased number of disrupted goblet cells and mucous release.

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Interference of oral immunization with the intestinal absorption of heterologous albumin

Cited by 96 publications

References 14 publications

Detection ofBifidobacteriumStrains that Induce Large Quantities of IgA

Detection ofBifidobacteriumStrains that Induce Large Quantities of IgA

Stimulatory effect of Shoyu polysaccharides from soy sauce on the intestinal immune system

Uptake of BSA and production of the antibody against BSA in rat intestine.

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