Detection of<i>Bifidobacterium</i>Strains that Induce Large Quantities of IgA

Yasui, Hisako; Nagaoka, Noriko; Mike, Akito; Hayakawa, Kazuhito; Ohwaki, Makoto

doi:10.3109/08910609209141310

Cited by 91 publications

(44 citation statements)

References 17 publications

(1 reference statement)

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“…Additionally, the increased fecal Bifidobacterium spp. count that was observed in the present study may have resulted in higher intestinal IgA levels; Bifidobacterium has previously been shown to induce IgA production 23) Two observations in the present study suggest enteromammary pathway involvement, which is characterized by the homing of immune cells. First, maternal supplementation with 1-kestose was found to increase the total IgA concentration in milk, but not in serum, at 17 days after delivery ( Fig.…”

Section: Discussionsupporting

confidence: 69%

1-Kestose consumption during pregnancy and lactation increases the levels of IgA in the milk of lactating mice

Jinno

Nakamura

Nagata

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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To examine the effect of dietary supplementation with 1-kestose on the IgA levels in milk, BALB/c mice were fed diets with or without 5% 1-kestose during pregnancy and lactation. The total and specific IgA levels in the milk were measured at 7 and 14 days after delivery. A two-way ANOVA with repeated measures resulted in a significant effect of 1-kestose-supplementation on total IgA concentrations (p < 0.05) and the level of anti-Bacteroides IgA (p < 0.05). A significant positive correlation was found between the mean count of Bacteroides spp. in maternal feces and the total IgA concentration in maternal milk (r = 0.55, p < 0.05), suggesting a potential link between the gut and mammary gland immune system. In conclusion, this study demonstrated the effects of dietary prebiotics on milk IgA production.

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Section: Discussionsupporting

confidence: 69%

1-Kestose consumption during pregnancy and lactation increases the levels of IgA in the milk of lactating mice

Jinno

Nakamura

Nagata

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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“…Interestingly, with regard to the amount of B. breve, all 10-day-old infants were separated into two groups: (i) infants where B. breve constituted up to 15% of the bifidobacterial load, and (ii) infants where it accounted for Ͼ75% of the bifidobacterial load. B. breve was shown to be an efficient inducer of serum IgA (35), a main immunoglobulin found in mucous secretion of intestinal and respiratory tract (36), which averts penetration of pathogenic microorganisms by preventing their adsorption to mucosal epithelium. Therefore, in the future it would be very interesting to investigate whether such a huge gap in B. breve abundance has a host-related cause or can be explained by bacterial competition.…”

Section: Discussionmentioning

confidence: 99%

Bifidobacterial Succession and Correlation Networks in a Large Unselected Cohort of Mothers and Their Children

Avershina

Storrø

Øien

et al. 2013

Appl Environ Microbiol

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c Bifidobacteria are a major microbial component of infant gut microbiota, which is believed to promote health benefits for the host and stimulate maturation of the immune system. Despite their perceived importance, very little is known about the natural development of and possible correlations between bifidobacteria in human populations. To address this knowledge gap, we analyzed stool samples from a randomly selected healthy cohort of 87 infants and their mothers with >90% of vaginal delivery and nearly 100% breast-feeding at 4 months. Fecal material was sampled during pregnancy, at 3 and 10 days, at 4 months, and at 1 and 2 years after birth. Stool samples were predicted to be rich in the species Bifidobacterium adolescentis, B. bifidum, B. dentium, B. breve, and B. longum. Due to high variation, we did not identify a clear age-related structure at the individual level. Within the population as a whole, however, there were clear age-related successions. Negative correlations between the B. longum group and B. adolescentis were detected in adults and in 1-and 2-year-old children, whereas negative correlations between B. longum and B. breve were characteristic for newborns and 4-month-old infants. The highly structured age-related development of and correlation networks between bifidobacterial species during the first 2 years of life mirrors their different or competing nutritional requirements, which in turn may be associated with specific biological functions in the development of healthy gut.

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“…Use of specific probiotic may aims to modulate host immune response to potential harmful antigens. Oral administration of B. bifidum was reported to stimulate IgA response to ovaalbumin [26] and B. breve was shown to regulae IgA response to cholera toxin in mice [27]. In similar manner, rise in humoral response in comparison to control study including an increment in rota virus specific antibody secreting cell in the IgA class was observed in the children with acute rotavirus diarrhea who received L. rhamnosus during the acute phase of diarrhea [8].…”

Section: Discussionmentioning

confidence: 77%

Oral Administration of LBKV-3 as Probiotic Enhances Immunoglobulin Level and Faecal Microflora in Malnutrate Children

Hajare¹

2017

J Prob Health

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Role of probiotics in regulation of immune system and development in microflora has begun to implicate in humans and animals. Inconsistent data exist regarding the effect of a single probiotic strain in malnutrate children. The aim of this study clinically proven Lactobacillus acidophilus strain LBKV-3 intended as probiotc for human was used to test its effect on modulation of immunoglobulin and composition of faecal microflora. To accomplish this task, 135 malnutrate children were orally administrated with buffalo milk as control, fresh curd as a special module for assessment of stimulatory effects and probiotic acidophilus milk used as a probiotic. During feeding, we evaluate the level of saliva IgA, serum IgG and IgE and faecal microflora. The result of our study demonstrated that the frequency of immunoglobulin and microflora was not affected when children consumed buffalo milk. In presence of fresh curd, the level of IgA, IgG and composition of friendly bacteria slightly increases and proportion of pathogenic bacteria declines. However, probiotic acidophilus milk significantly triggers the level of IgA and IgG as well as population of helpful bacteria rises and concentration of pathogenic bacteria declines in comparison to fresh curd. Irrespective of IgA and IgG, the ratio of IgE reduces in presence of fresh curd and probiotic acidophilus milk. Thus, our study showed that probiotic has positive effects on modulation of immunoglobulin and regulation of gut microflora. To confirm these findings, large-scale experiments involving the use of a large number of humans of different age groups and under different health and nutritional condition are required to be performed. Moreover, a different dose or strain of probiotic also warrants further confirmation.

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Detection ofBifidobacteriumStrains that Induce Large Quantities of IgA

Cited by 91 publications

References 17 publications

1-Kestose consumption during pregnancy and lactation increases the levels of IgA in the milk of lactating mice

1-Kestose consumption during pregnancy and lactation increases the levels of IgA in the milk of lactating mice

Bifidobacterial Succession and Correlation Networks in a Large Unselected Cohort of Mothers and Their Children

Oral Administration of LBKV-3 as Probiotic Enhances Immunoglobulin Level and Faecal Microflora in Malnutrate Children

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