Interference Between Respiratory Syncytial Virus and Human Rhinovirus Infection in Infancy

Achten, Niek B.; Wu, Pingsheng; Bont, Louis; Blanken, Maarten O; Gebretsadik, Tebeb; Chappell, James D.; Wang, Li; Yu, Chang; Larkin, Emma K.; Carroll, Kecia N.; Anderson, Larry J.; Moore, Martin L.; Sloan, Chantel D.; Hartert, Tina V.

doi:10.1093/infdis/jix031

Cited by 73 publications

(54 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding could be explained by the genetic factors described in both genders. 20 Despite the fact that RSV A/B is frequent worldwide and its distribution is consistent with a variety of reports in both developing and developed countries, RV has been increasingly reported by previous studies [21][22][23] and was the most frequently detected pathogen in the present study. Its high prevalence makes its infection more serious.…”

supporting

confidence: 91%

Demographic and seasonal characteristics of respiratory pathogens in neonates and infants aged 0 to 12 months in the Central‐East region of Tunisia

Khalifa

Hannachi

Guerrero

et al. 2018

Journal of Medical Virology

View full text Add to dashboard Cite

Background This study aimed to characterize the epidemiology of pathogenic respiratory agents in patients aged 0 to 12 months and hospitalized for acute respiratory infections in Tunisia between 2013 and 2014. Methods A total of 20 pathogens, including viruses, Mycoplasma pneumoniae , and Streptococcus pneumoniae , were detected using molecular sensitive assays, and their associations with the patient’s demographic data and season were analyzed. Results Viral infectious agents were found in 449 (87.2%) of 515 specimens. Dual and multiple infectious agents were detected in 31.4% and 18.6% of the samples, respectively. Viral infection was predominant in the pediatric environment (90.8%, P < 0.001), male patients (88.0%), and spring (93.8%). Rhinovirus was the most detected virus (51.8%) followed by respiratory syncytial virus A/B (34.4%), coronavirus group (18.5%), adenovirus (17.9%), and parainfluenza viruses 1‐4 (10.9%). Respiratory Syncytial virus A/B was significantly associated with gender (38.0% male cases vs 28.3% female cases, P = 0.02). Infections by Adenovirus , Bocavirus , and Metapneumovirus A/B increased with increasing age of patients (predominated cases aged 6‐12 months, P < 0.001). S. pneumoniae was detected in 30.9% of th tested samples. In 18.2% of the negative viral infections, only S. pneumoniae was identified. Conclusion A predominance of the rhinovirus infection was observed in this study. Coronavirus subtypes were described for the first time in Tunisia. The observed different pathogenic profiles across age groups could be helpful to avoid the misclassification of patients presenting with ARIs at the triage level when no standardized protocol is available. This study will provide clues for physicians informing decisions regarding preventive strategies and medication in Tunisia.

show abstract

supporting

confidence: 91%

Demographic and seasonal characteristics of respiratory pathogens in neonates and infants aged 0 to 12 months in the Central‐East region of Tunisia

Khalifa

Hannachi

Guerrero

et al. 2018

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…Recent efforts to incorporate a novel strategy, minimally invasive sampling of tissue (MITS) for histopathology, immunohistochemistry, and molecular studies, coupled with verbal autopsies and PCR detection of the virus in nasopharyngeal secretions should improve our understanding of the problem . In addition, respiratory virus surveillance will be critical after licensure of vaccines or antibodies to gauge their impact and monitor potential viral replacement, if RSV is cornered by these products . The emergence of antiviral drugs against respiratory pathogens in coming years may further encourage testing …”

Section: The Futurementioning

confidence: 99%

Respiratory syncytial virus is an “opportunistic” killer

Caballero

Polack

2018

Pediatric Pulmonology

View full text Add to dashboard Cite

Respiratory syncytial virus (RSV), responsible for more than three million yearly hospitalizations and up to 118 000 deaths in children under 5 years, is the leading pulmonary cause of death for this age group that lacks a licensed vaccine. Ninety‐nine percent of deaths due to the virus occur in developing countries. In‐hospital RSV fatalities affect previously healthy term infants in association with bacterial sepsis, clinically significant pneumothoraxes and, to a lesser extent, comorbid conditions. Community deaths affect low‐income children from socially vulnerable families and appear to be as frequent as inpatient fatalities. In industrialized countries, RSV deaths occur almost exclusively in children with premorbid conditions.In a sense, RSV is an “opportunistic” killer. It needs a synergistic premorbid, medical practice‐related, infectious, or social co‐factor to cause a fatal outcome. But while the complex problems associated with these co‐factors await solutions, candidate vaccines, long‐lived monoclonal antibodies and antivirals against RSV are under clinical evaluation. It seems reasonable to predict that the landscape of RSV infections will look different in the next decade.

show abstract

“…[62,69]. As we improve our ability to remove non-patient test results from the Trend dataset we will be able to characterize specific virus co-detection rates and their significance [53,54,66,67,70,71].…”

Section: The Seasonality and Co-infections Of Respiratory Pathogensmentioning

confidence: 99%

Automated Real-Time Collection of Pathogen-Specific Diagnostic Data: Syndromic Infectious Disease Epidemiology (Preprint)

Meyers¹,

Ginocchio²,

Faucett³

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

Interference Between Respiratory Syncytial Virus and Human Rhinovirus Infection in Infancy

Abstract: A negative association of RSV on HRV codetection was consistently observed across populations, seasons, disease severity, and geographical regions. Suppressing RSV infection by RSV immunoprophylaxis might increase the risk of having HRV infection.

Cited by 73 publications

References 33 publications

Demographic and seasonal characteristics of respiratory pathogens in neonates and infants aged 0 to 12 months in the Central‐East region of Tunisia

Demographic and seasonal characteristics of respiratory pathogens in neonates and infants aged 0 to 12 months in the Central‐East region of Tunisia

Respiratory syncytial virus is an “opportunistic” killer

Automated Real-Time Collection of Pathogen-Specific Diagnostic Data: Syndromic Infectious Disease Epidemiology (Preprint)

Contact Info

Product

Resources

About