Interfacial and spectroscopic behavior of phenothiazine drug/bile salt mixture in urea solution

Kumar, Dileep; Azum, Naved; Rub, Malik Abdul; Asiri, Abdullah M.

doi:10.1007/s11696-021-01634-7

Cited by 19 publications

(2 citation statements)

References 42 publications

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“…One more thermodynamic parameter, named minimum free energy ( G min ), which is attained at the outmost adsorption at equilibrium, is also used to determine the attractive interaction/synergism at the interfacial boundary via Equation (11) [ 31 , 32 ].

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Section: Resultsmentioning

confidence: 99%

Interaction of TX-100 and Antidepressant Imipramine Hydrochloride Drug Mixture: Surface Tension, 1H NMR, and FT-IR Investigation

Rub

Azum

Kumar

et al. 2022

Gels

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Interfacial interaction amongst the antidepressant drug-imipramine hydrochloride (IMP) and pharmaceutical excipient (triton X-100 (TX-100-nonionic surfactant)) mixed system of five various ratios in dissimilar media (H2O/50 mmol·kg−1 NaCl/250 mmol·kg−1 urea) was investigated through the surface tension method. In addition, in the aqueous solution, the 1H-NMR, as well as FT-IR studies of the studied pure and mixed system were also explored and deliberated thoroughly. In NaCl media, properties of pure/mixed interfacial surfaces enhanced as compared with the aqueous system, and consequently the synergism/attractive interaction among constituents (IMP and TX-100) grew, whereas in urea (U) media a reverse effect was detected. Surface excess concentration (Γmax), composition of surfactant at mixed monolayer (X1σ), activity coefficient (f1σ (TX-100) and f2σ (IMP)), etc. were determined and discussed thoroughly. At mixed interfacial surfaces interaction, parameter (βσ) reveals the attractive/synergism among the components. The Gibbs energy of adsorption (ΔGadso) value attained was negative throughout all employed media viewing the spontaneity of the adsorption process. The 1H NMR spectroscopy was also employed to examine the molecular interaction of IMP and TX-100 in an aqueous system. FT-IR method as well illustrated the interaction amongst the component. The findings of the current study proposed that TX-100 surfactant could act as an efficient drug delivery vehicle for an antidepressant drug. Gels can be used as drug dosage forms due to recent improvements in the design of surfactant systems. Release mechanism of drugs from surfactant/polymer gels is dependent upon the microstructures of the gels and the state of the drugs within the system.

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…”

Section: Resultsmentioning

confidence: 99%

Interaction of TX-100 and Antidepressant Imipramine Hydrochloride Drug Mixture: Surface Tension, 1H NMR, and FT-IR Investigation

Rub

Azum

Kumar

et al. 2022

Gels

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“…The proclivity of amphiphilic molecules to self-aggregates can also be used to evaluate the different thermodynamic parameters. One of the thermodynamic parameters, known as Gibbs free energy (∆G o m ), was assessed for the association of singular components (IMP and TX-100) along with their blended system in different ratios using Equation ( 7) [51][52][53].…”

Section: Thermodynamic Parametermentioning

confidence: 99%

Investigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study

et al. 2021

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In this paper, the interaction of imipramine hydrochloride (IMP, antidepressant drug) and a non-ionic surfactant Triton X-100 (TX-100) mixture in five different ratios through the tensiometric method in different solvents (aqueous/0.050 mol·kg−1 aqueous NaCl/0.250 mol·kg−1 aqueous urea (U)) were examined thoroughly at a temperature of 298 K. UV–Visible studies in an aqueous system of IMP + TX-100 mixtures were also investigated and discussed in detail. The pure (IMP and TX-100) along with the mixtures’ critical micelle concentration (cmc) were assessed by a tensiometric technique. The obtained deviation of the mixtures’ cmc values from their ideal values revealed the nonideal behavior of IMP + TX-100 mixtures amongst IMP and TX-100. Compared to aqueous systems, in the presence of aqueous NaCl, several changes in micelles/mixed micelles occurred, and hence a synergism/attractive interaction amongst components was found increased while in the existence of U, the synergism/attractive interaction between them decreased. The evaluated interaction parameter (βRb) value of mixed micelles showed the attractive or synergism between the IMP and TX-100. Various evaluated thermodynamic parameters in an aqueous system showed that the mixed micellization of the IMP + TX-100 mixture was an entropically spontaneous phenomenon, although the existence of salt in all studied systems can somewhat increase the spontaneity of the micellization process and in the aqueous U system, the spontaneity of the micellization process decreased. In an aqueous system, the interaction between IMP and TX-100 was also confirmed by UV–Visible study.

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Effect of a Biosurfactant on Micellar Behavior of Cationic Surfactants in Aqueous Solution

Moradi

Bagheri

2022

J Solution Chem

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Interfacial and spectroscopic behavior of phenothiazine drug/bile salt mixture in urea solution

Cited by 19 publications

References 42 publications

Interaction of TX-100 and Antidepressant Imipramine Hydrochloride Drug Mixture: Surface Tension, 1H NMR, and FT-IR Investigation

Interaction of TX-100 and Antidepressant Imipramine Hydrochloride Drug Mixture: Surface Tension, 1H NMR, and FT-IR Investigation

Investigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study

Effect of a Biosurfactant on Micellar Behavior of Cationic Surfactants in Aqueous Solution

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