Behavior synthesis and optimization beyond the register transfer level require an efficient utilization of the underlying platform features. This paper presents a platform-based resource binding approach based on a distributed register-file microarchitecture (DRFM), which makes efficient use of distributed embedded memory blocks as register files in modern FPGAs. DRFM contains multiple islands, each having a local register file, a functional unit pool and data-routing logic. Compared to the traditional discrete-register counterpart, a DRFM allows use of the platformfeatured on-chip memory or register-file IP blocks to implement its local register files, and this results in a substantial saving of multiplexing logic and global interconnects. DRFM provides a useful architectural template and a direct optimization objective for minimizing inter-island connections for synthesis algorithms. Given the scheduling solution and resource (functional units) constraints, two novel algorithms in the resource binding stage are developed based on DRFM: (i) A simultaneous DRFM clustering and binding algorithm, which decides the configuration of DRFM and the assignment of operations into islands with the focus on optimizing global connections; (ii) A data-forwarding scheduling algorithm, which takes advantage of the operation slacks to handle the read-port restriction of register files. On the Xilinx Virtex4 FPGA platform, experimental results with a set of real-life test cases show a 50% logic area reduction achieved by applying our approach, with a 14.6% performance improvement, compared to the traditional discrete-register-based approach. Also, experiments on small-size designs show that our algorithm produces the same number of total connections and at most one more maximum feeding-in connection compared to optimal solutions generated by ILP.