Intérêt de la recherche du cytomégalovirus par polymerase chain reaction dans le syndrome de Posner-Schlossman

Rodier-Bonifas, C.; Pl, Cornut; Billaud, Geneviève; Lina, B.; Burillon, C.; Denis, P.

doi:10.1016/j.jfo.2010.10.008

Cited by 24 publications

(5 citation statements)

References 7 publications

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“…To the best of our knowledge, this is the first report to evaluate the association of serum cytokines with PSS. In view of the important role of CMV in the pathogenesis of PSS [3,4], CMV-IgG and CMV-IgM were further detected in all PSS patients and controls by indirect ELISA. However, since a history of ophthalmic CMV infection had been excluded from both PSS patients and controls by examining their previous medical records, the CMV infection rates of PSS patients and controls were lower than expected in the general population [17].…”

Section: Discussionmentioning

confidence: 99%

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Serum Th1 and Th17 related cytokines and autoantibodies in patients with Posner-Schlossman syndrome

et al. 2017

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Posner-Schlossman syndrome (PSS) shares some clinical features with uveitis and open angle glaucoma. Cytokines and autoantibodies have been associated with uveitis and open angle glaucoma. However, the role of serum cytokines and autoantibodies in the pathogenesis of PSS remains unknown. This study aimed to evaluate the associations of type 1 T helper (Th1) and Th17 related cytokines and autoantibodies with PSS. Peripheral blood serum samples were collected from 81 patients with PSS and 97 gender- and age-matched healthy blood donors. Th1 and Th17 related cytokines, including interleukin-1β (IL-1β), IL-12, tumor necrosis factor-α (TNF-α), interferon- γ (IFN-γ), IL-6 and IL-17, and glucose-6-phosphate isomerase (GPI) were determined by double antibody sandwich ELISA. Anti-nuclear antibody (ANA), anti-keratin antibody (AKA) and anti-neutrophil cytoplasmic antibody (ANCA) were detected by indirect immunofluorescence assay. Anti-cardiolipin antibody (ACA)-IgG, ACA-IgM, ACA-IgA, anti-double stranded DNA (anti-dsDNA) and anti-cyclic citrullinated peptide antibody (anti-CCP) were detected by indirect ELISA. Serum levels of IL-1β, IL-12 and IL-6 in PSS patients were significantly lower than those in controls (P < 0.003), and these associations survived the Bonferroni correction (Pc < 0.018). There was no significant difference in serum levels of TNF-α, IFN-γ and IL-17 between the PSS and control groups (Pc > 0.12). Positive rate of serum anti-dsDNA in PSS patients was significantly higher than that in the control group (P = 0.002, Pc = 0.018), while positive rates of serum ANA, AKA, ANCA, ACA-IgG, ACA-IgM, ACA-IgA, GPI and anti-CCP in the PSS group were not significantly different from those in the control group (Pc > 0.09). These results suggest that anti-dsDNA may contribute to the pathogenesis of PSS, while Th1 and Th17 related cytokines and other autoantibodies may not be major contributors to PSS.

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Section: Discussionmentioning

confidence: 99%

“…The etiology of PSS remains unclear. Pathogenic microbial infection mainly caused by cytomegalovirus (CMV) has been proposed as the initial and leading cause of PSS [3,4]. In addition, cytokine, allelic heterogenicity and vascular endothelial dysfunction can all contribute to the pathogenesis of PSS [4–7].…”

Section: Introductionmentioning

confidence: 99%

Serum Th1 and Th17 related cytokines and autoantibodies in patients with Posner-Schlossman syndrome

et al. 2017

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“…Equally, DNA from HSV and cytomegalovirus (CMV) has been found in the aqueous of patients with Posner-Schlossman syndrome. [70][71][72] Presumably, in those types of uveitic glaucoma that present with acutely raised IOP, the inflammatory debris and a degree of trabeculitis dominate to impair trabecular outflow in the acute setting; ciliary body shutdown and increased uveoscleral outflow may occur to a lesser extent. This, therefore, leads to an acute rise in pressure.…”

Section: What Happens In the Clinical Setting?mentioning

confidence: 99%

The Pathogenesis of Raised Intraocular Pressure in Uveitis

Baneke

Lim

Stanford

2015

Current Eye Research

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“…A smaller study evaluated aqueous samples of 7 patients with glaucomatocyclitic crisis and found 5 of these samples to be positive for CMV by PCR. Two of these patients were treated with oral antiviral therapy, and relapses occurred in these cases after cessation of treatment, suggesting that CMV is a potential cause of glaucomatocyclitic crisis and that oral valganciclovir may be an effective treatment [53]. …”

Section: Utility Of Pcr In Evaluation Of Anterior Segment Diseasementioning

confidence: 99%

Role of Molecular Diagnostics in Ocular Microbiology

Taravati¹,

Lam²,

Gelder³

2013

Curr Ophthalmol Rep

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Although microbial culture remains the gold standard for diagnosis of many ocular infections, the technique is limited by low yield, inability to detect certain organisms, and potentially long delays to results. DNA-based molecular diagnostic techniques use detection of specific nucleic acid sequences as evidence for presence of suspected pathogens. The polymerase chain reaction (PCR) is a powerful molecular biology technique that allows for detection of fewer than 10 copies of pathogen genome. Recent technical advances in PCR have permitted quantitation of pathogen load using quantitative PCR (qPCR), and have permitted multiplexing of primer sets. Use of pan-bacterial and pan-fungal primers for ribosomal DNA sequences has allowed diagnosis of bacterial and fungal infections using molecular techniques. In this review, we highlight recent advances in the application of PCR to the diagnosis of anterior segment and posterior segment ocular infectious diseases.

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Intérêt de la recherche du cytomégalovirus par polymerase chain reaction dans le syndrome de Posner-Schlossman

Cited by 24 publications

References 7 publications

Serum Th1 and Th17 related cytokines and autoantibodies in patients with Posner-Schlossman syndrome

Serum Th1 and Th17 related cytokines and autoantibodies in patients with Posner-Schlossman syndrome

The Pathogenesis of Raised Intraocular Pressure in Uveitis

Role of Molecular Diagnostics in Ocular Microbiology

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