Intérêt d’une formule infantile épaissie avec activité lactasique dans la prise en charge des troubles digestifs bénins du nourrisson

Roy, P.; Aubert-Jacquin, C.; Avart, C.; Gontier, Camille

doi:10.1016/j.arcped.2004.10.001

Cited by 13 publications

(18 citation statements)

References 29 publications

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“…Hence, formula ii, iii, and iv are composed of a mixture of fermented and nonfermented infant formula in a ratio of 15:85 (ii) or 50:50 (iii, iv). The rationale to supplement prebiotics to a product with a level of 50% fermented formula was based on the previously observed beneficial effects on gut comfort ( 8 ). The level of 15% fermented formula was included to assess a potential dose dependency given the unknown effect on safety and tolerance of the newly developed formulae and has been shown to be well-tolerated ( 29 ).…”

Section: Methodsmentioning

confidence: 99%

Partly Fermented Infant Formulae With Specific Oligosaccharides Support Adequate Infant Growth and Are Well‐Tolerated

Huet

Abrahamse‐Berkeveld

Tims

et al. 2016

J. pediatr. gastroenterol. nutr.

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Objective:Fermented formulae (FERM) and a specific mixture of 90% short-chain galacto-oligosaccharides and 10% long-chain fructo-oligosaccharides (scGOS/lcFOS; 9:1) have a potential beneficial effect on gastrointestinal function and microbiota development in infants. The present study assessed the safety and tolerance of the combination of partly fermented infant milk formulae and scGOS/lcFOS compared with either 1 feature, in healthy term infants.Methods:Four hundred thirty-two infants were enrolled before 28 days of age and followed up to 17 weeks of age and assigned to 1 of the 4 groups: (i) formula with scGOS/lcFOS, (ii) scGOS/lcFOS + 15% FERM, (iii) scGOS/lcFOS + 50% FERM, or (iv) 50% fermented formula (50% FERM). Primary outcome was daily weight gain during intervention (equivalence criterion: difference in daily weight gain ≤3 g/day). Infants’ anthropometrics, formula intake, number, and type of (serious) AEs were monitored monthly. Stool samples were collected at baseline and after 17 weeks for analysis of physiological and microbiological parameters.Results:Equivalence of weight gain per day was demonstrated in both the intention-to-treat and per-protocol population, with a mean weight gain (SD) of 29.7 (6.1), 28.2 (4.8), 28.5 (5.0), and 28.7 (5.9) g/day for the groups i to iv respectively. No differences were observed in other growth parameters, formula intake, and the number or severity of AEs. In all scGOS/lcFOS-containing formulae, a beneficial effect of scGOS/lcFOS was observed, indicated by the lower pH, lower Clostridium difficile levels, and higher secretory immunoglobulin A levels.Conclusions:The partly fermented infant milk formulae containing the specific mixture scGOS/lcFOS were well-tolerated and resulted in normal growth in healthy infants.

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Section: Methodsmentioning

confidence: 99%

Partly Fermented Infant Formulae With Specific Oligosaccharides Support Adequate Infant Growth and Are Well‐Tolerated

Huet

Abrahamse‐Berkeveld

Tims

et al. 2016

J. pediatr. gastroenterol. nutr.

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“…Despite their widespread use over many years, only six randomized, controlled, double-blind studies [41,54,55,56,57,58] have been performed with fermented infant formulae. See Table 1 for an overview of recent (1989–2013) clinical studies with fermented infant formulae.…”

Section: The Evidence: Benefits Of Fermented Formulae On Gi Functimentioning

confidence: 99%

“…Various thickeners can be added to formula (or expressed human milk) to increase the viscosity and have been clinically proven to alleviate reflux and regurgitation in infants under six months [59,60]. Thickeners added to a fermented formula are applied in the study by Roy and co-workers [54]: after 15 days, a fermented formula thickened with corn starch (with a high amylopectin content) was shown to decrease the frequency and severity of regurgitation, belching and hiccups in 47 infants aged 1–3 months. To what extent the fermentation and the presence of lactase in the formula contributed to these effects (on top of the added thickening starch) could not be determined.…”

Section: The Evidence: Benefits Of Fermented Formulae On Gi Functimentioning

confidence: 99%

“…A decrease in intensity of the overall digestive discomfort was recorded for both groups studied, but the decrement was significantly larger in the fermented formula group [54]. More specifically, the decrease in “gas intensity” (flatulence) was significantly more pronounced in the fermented formula group; also, “intestinal bloating” tended to be lower in the fermented formula group.…”

Section: The Evidence: Benefits Of Fermented Formulae On Gi Functimentioning

confidence: 99%

“…The lactase enzyme produced by Streptococcus thermophilus or most Lactobacillus bulgaricus strains during the fermentation process resists gastric stress and is also postulated to be one of the main engines responsible for the beneficial health effect of fermented infant formulae, particularly regarding the effect observed on symptoms linked to the distal digestive tract, i.e. , the colon [54]. …”

Section: Potential Mechanisms Of Action: How?mentioning

confidence: 99%

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GI Symptoms in Infants Are a Potential Target for Fermented Infant Milk Formulae: A Review

et al. 2014

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Besides pre- and pro-biotic-containing infant formulae, fermented infant formulae are commonly used to relieve or prevent symptoms of gastrointestinal (GI) discomfort in young infants. During the fermentation process in cow’s milk-based formulae, the beneficial bacteria modulate the product by forming several beneficial compounds, which contribute to the alleviation of the symptoms observed. This review summarizes the clinical evidence on the impact of fermented infant formulae on common pediatric GI-symptoms. The potential mechanisms involved are discussed: i.e., the lactose and protein (in-) digestibility, effects on gastric emptying and gut transit and modulation of the colonic microbiota. Although initial evidence indicates a beneficial effect of fermented formulae on GI discomfort in newborns, validation and confirmation of the clinical proof obtained so far is warranted, as well as further research to (more fully) understand the mode of action.

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Fermented infant formulas without live bacteria: a systematic review

2015

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Limited available evidence suggests that the use of fermented infant formula, compared with the use of standard infant formula, does not offer clear additional benefits, although some benefit on gastrointestinal symptoms cannot be excluded. What is known • Fermented formulas, i.e., those fermented with lactic acid-producing bacteria during the production process and not containing significant amounts of viable bacteria in the final product, are widely available in many countries. What is new • Limited evidence available suggests that the use of fermented infant formula, compared with the use of standard infant formula, does not offer clear additional benefits, although some benefit on gastrointestinal symptoms cannot be excluded. At the same time, no negative health effects have been documented.

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Intérêt d’une formule infantile épaissie avec activité lactasique dans la prise en charge des troubles digestifs bénins du nourrisson

Cited by 13 publications

References 29 publications

Partly Fermented Infant Formulae With Specific Oligosaccharides Support Adequate Infant Growth and Are Well‐Tolerated

Partly Fermented Infant Formulae With Specific Oligosaccharides Support Adequate Infant Growth and Are Well‐Tolerated

GI Symptoms in Infants Are a Potential Target for Fermented Infant Milk Formulae: A Review

Fermented infant formulas without live bacteria: a systematic review

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