Interest of cellular differentiation in the production of vincristine and vinblastine in suspension cultures of Catharanthus roseus (L.) G Don.

Zavala-Ortiz, Daniel; México, Tecnológico Nacional de; Martínez-Montero, M.J.; Guédon, Emmanuel; Marc, Annie; Ebel, Bruno; Barradas-Dermitz, Dulce María; Hayward‐Jones, Patricia M.; Mata-Rosas, Martín; Aguilar‐Uscanga, María Guadalupe

doi:10.24275/rmiq/bio2228

Cited by 2 publications

(1 citation statement)

References 37 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…f.) Lindau [162], Catharanthus roseus (L.) G Don. [163], and Artemisia absinthium [164], where higher production of PDSM were obtained under light exposure. On the other hand, species such as Plumbago europaea L. [160] showed 1.7 times the production of plumbagina, the main bioactive compound, when CSC were cultured in darkness; besides, Ajuga bracteosa exhibited a higher concentration of PDSM and antioxidant activity when its CSC was subjected to darkness and methyl jasmonate as elicitor [165], and Ruta graveolens with a 3.14-fold increase in total flavonoid content [166].…”

Section: Lightmentioning

confidence: 95%

Engineering Considerations to Produce Bioactive Compounds from Plant Cell Suspension Culture in Bioreactors

Motolinía-Alcántara

Castillo‐Araiza

Rodrı́guez-Monroy

et al. 2021

Plants

View full text Add to dashboard Cite

The large-scale production of plant-derived secondary metabolites (PDSM) in bioreactors to meet the increasing demand for bioactive compounds for the treatment and prevention of degenerative diseases is nowadays considered an engineering challenge due to the large number of operational factors that need to be considered during their design and scale-up. The plant cell suspension culture (CSC) has presented numerous benefits over other technologies, such as the conventional whole-plant extraction, not only for avoiding the overexploitation of plant species, but also for achieving better yields and having excellent scaling-up attributes. The selection of the bioreactor configuration depends on intrinsic cell culture properties and engineering considerations related to the effect of operating conditions on thermodynamics, kinetics, and transport phenomena, which together are essential for accomplishing the large-scale production of PDSM. To this end, this review, firstly, provides a comprehensive appraisement of PDSM, essentially those with demonstrated importance and utilization in pharmaceutical industries. Then, special attention is given to PDSM obtained out of CSC. Finally, engineering aspects related to the bioreactor configuration for CSC stating the effect of the operating conditions on kinetics and transport phenomena and, hence, on the cell viability and production of PDSM are presented accordingly. The engineering analysis of the reviewed bioreactor configurations for CSC will pave the way for future research focused on their scaling up, to produce high value-added PDSM.

show abstract

Section: Lightmentioning

confidence: 95%

Engineering Considerations to Produce Bioactive Compounds from Plant Cell Suspension Culture in Bioreactors

Motolinía-Alcántara

Castillo‐Araiza

Rodrı́guez-Monroy

et al. 2021

Plants

View full text Add to dashboard Cite

show abstract

Development of Catharanthus callus cell lines for indole-derived alkaloids production

Zavala-Ortiz,

Infanzón-Rodríguez,

Gomez-Rodriguez

et al. 2024

South African Journal of Botany

View full text Add to dashboard Cite

Interest of cellular differentiation in the production of vincristine and vinblastine in suspension cultures of Catharanthus roseus (L.) G Don.

Abstract: Modelado de la biodegradación en biorreactores de lodos de hidrocarburos totales del petróleo intemperizados en suelos y sedimentos (Biodegradation modeling of sludge bioreactors of total petroleum hydrocarbons weathering in soil and sediments)

Cited by 2 publications

References 37 publications

Engineering Considerations to Produce Bioactive Compounds from Plant Cell Suspension Culture in Bioreactors

Engineering Considerations to Produce Bioactive Compounds from Plant Cell Suspension Culture in Bioreactors

Development of Catharanthus callus cell lines for indole-derived alkaloids production

Contact Info

Product

Resources

About