Interconversion of sphingomyelin and ceramide in adult Schistosoma mansoni

Redman, C.; Kennington, Sonja; Spathopoulou, Thania; Kusel, J. R.

doi:10.1016/s0166-6851(97)00151-5

Cited by 22 publications

(20 citation statements)

References 47 publications

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“…Inter-conversion of sphingomyelin and ceramide is reported in S. mansoni (Redman et al 1997). Similar function of sphingomyelin may be attributed in case of P. cervi.…”

Section: Discussionsupporting

confidence: 78%

Comparison of fatty acid contents of the neutral and phospholipids of the trematode Paramphistomum cervi and liver of its host, Capra hircus

Ghosh¹,

Misra²

2013

J Parasit Dis

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The present observation records the lipid classes and their fatty acid composition of the neutral lipid and phospholipid of the trematode Paramphistomum cervi and liver of its host Capra hircus, the common Indian goat. Thin Layer Chromatography and Gas Liquid Chromatography were used to identify different neutral lipid and phospholipid components. The results show that among the neutral lipid fractions, the amount of combined hydrocarbon, wax ester and steryl ester is more or less equal in parasite and its host, but the percent of triacylglycerol is more in host liver than the parasite and the percent of total sterol is more in parasite than that of its host liver. Among the phospholipid fractions, phosphatidylinositol and phosphatidylethanolamine in the trematode parasite P. cervi and phosphatidylcholine and cardiolipin in the host's liver are the major components. The predominant fatty acids in the neutral lipid and phospholipid fractions of both the host liver and the trematode P. cervi include C16:0, C18:0, C18:1, and C18:2. The results reveal that the parasite P. cervi take up almost all the lipid and fatty acids from their host, which is required for their life cycle.

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“…Inter-conversion of sphingomyelin and ceramide is reported in S. mansoni (Redman et al 1997). Similar function of sphingomyelin may be attributed in case of P. cervi.…”

Section: Discussionsupporting

confidence: 78%

Comparison of fatty acid contents of the neutral and phospholipids of the trematode Paramphistomum cervi and liver of its host, Capra hircus

Ghosh¹,

Misra²

2013

J Parasit Dis

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“…Scavenging of lipids from the host environment for membrane synthesis during proliferation, growth, and development to the next stage and for energy is probably a common phenomenon in a parasite's life. Incorporation of phospholipids, fatty acids, cholesterol, and lysophospholipids from culture media and/or the host has been reported in several parasitic protozoa (Brouwers et al 1997; Lujan, Mowatt, and Nash 1996; Redman et al 1997; Stevens et al 1997; Vial and Ancelin 1998) and the nematode Schistosoma mansoni (Furlong et al 1995). The depletion of lipids and fatty acids in culture media with the increase of P. marinus meronts indicated that P. marinus effectively assimilated exogenous lipids and used them for proliferation.…”

Section: Discussionmentioning

confidence: 99%

Lipid Class and Fatty Acid Composition of the Protozoan Parasite of Oysters, Perkinsus marinus Cultivated in Two Different Media

Soudant

Chu

2001

J Eukaryotic Microbiology

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The meront stage of the oyster protozoan parasite, Perkinsus marinus, cultivated in two media with different fatty acid profiles was analyzed for its fatty acid and lipid class composition. The composition of fatty acids in the prezoosporangium stage of the parasite as well as that of the host oyster were investigated. Although the lipid class composition of meronts was dominated by phospholipids and triacylglycerol, there was no triaclgycerol detected in either culture medium. Despite the difference in fatty acid composition of the two media, the fatty acid composition of meronts in each medium was dominated by 14:0, 16:0, 18:0, 18:1(n-9), 20: (n-9), 18:2(n-6) and 20:4(n-6), a profile that differed from its host. The quantities of total lipids and fatty acids in meronts increased as the number of meronts increased and far exceeded the initial amounts in the media and in the initial cell inoculum. The meronts harvested 25 d post-inoculation, had about 3 to 6 times higher total lipids and 4 to 13 times higher fatty acids than the amounts contained in the media. The fatty acid profiles of both prezoosporangia and oysters resembled each other and consisted primarily of 16:0, 20:4(n-6), 20:5(n-3), 22:2delta7,15, and 22:6(n-3). These results indicate that during meront proliferation, the parasite synthesizes certain fatty acids and lipid classes. For development from meront to prezoosporangium, the parasite may rely on its host for lipid resources.

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“…[15][16][17] The proposed ARA killing mechanism was activation of parasite surface membrane-associated neutral sphingomyelinase with consequent apical bilayer SM hydrolysis and disruption of the SM-based hydrogen barrier shielding the worm from the hostile elements of the immune system. [15][16][17][18][19][20][21][22] Expectedly, ARA was shown to display significant therapeutic effects in mice and hamsters infected with S. mansoni or S. haematobium, inducing 50-78% reductions in worm burdens and worm egg loads. 16,17 ARA treatment of mice and hamsters was safe.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Arachidonic Acid for Treatment of Schistosoma mansoni-Infected Children in Menoufiya, Egypt

Selim

Sagheer

Amir

et al. 2014

The American Journal of Tropical Medicine and Hygiene

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Abstract. Arachidonic acid (ARA), an omega-6 fatty acid, kills juvenile and adult schistosomes in vitro and displays highly significant and safe therapeutic effects in mice and hamsters infected with Schistosoma mansoni or S. haematobium. This study aims to examine the efficacy and safety of ARA in treatment of school-age children infected with S. mansoni. In total, 66 S. mansoni-infected schoolchildren (20-23 children/study arm) received a single dose of 40 mg/kg praziquantel (PZQ), ARA (10 mg/kg per day for 15 days), or PZQ combined with ARA. The children were examined before and after treatment for worm egg counts in stool and blood biochemical and immunological parameters. ARA proved to be as efficacious as PZQ in treatment of schoolchildren with low infection intensity (78% and 85% cure rates, respectively). For moderate-intensity infection, the ARA and PZQ combination led to 100% cure rate. Biochemical, hematological, and immunological parameters were either unchanged or ameliorated after ARA therapy.

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Interconversion of sphingomyelin and ceramide in adult Schistosoma mansoni

Cited by 22 publications

References 47 publications

Comparison of fatty acid contents of the neutral and phospholipids of the trematode Paramphistomum cervi and liver of its host, Capra hircus

Comparison of fatty acid contents of the neutral and phospholipids of the trematode Paramphistomum cervi and liver of its host, Capra hircus

Lipid Class and Fatty Acid Composition of the Protozoan Parasite of Oysters, Perkinsus marinus Cultivated in Two Different Media

Efficacy and Safety of Arachidonic Acid for Treatment of Schistosoma mansoni-Infected Children in Menoufiya, Egypt

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