Interconnected Toroidal Hydrogels for Islet Encapsulation

Ernst, Alexander U.; Wang, Long‐Hai; Ma, Minglin

doi:10.1002/adhm.201900423

Cited by 42 publications

(48 citation statements)

References 37 publications

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“…6, H and I ). Note that silicone surface roughness modification was not needed, as hydrogel attachment to the twisted structure was sufficiently robust, consistent with other findings from our group ( 46 , 47 ).…”

Section: Resultssupporting

confidence: 90%

An inverse-breathing encapsulation system for cell delivery

et al. 2021

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Cell encapsulation represents a promising therapeutic strategy for many hormone-deficient diseases such as type 1 diabetes (T1D). However, adequate oxygenation of the encapsulated cells remains a challenge, especially in the poorly oxygenated subcutaneous site. Here, we present an encapsulation system that generates oxygen (O2) for the cells from their own waste product, carbon dioxide (CO2), in a self-regulated (i.e., “inverse breathing”) way. We leveraged a gas-solid (CO2–lithium peroxide) reaction that was completely separated from the aqueous cellular environment by a gas permeable membrane. O2 measurements and imaging validated CO2-responsive O2 release, which improved cell survival in hypoxic conditions. Simulation-guided optimization yielded a device that restored normoglycemia of immunocompetent diabetic mice for over 3 months. Furthermore, functional islets were observed in scaled-up device implants in minipigs retrieved after 2 months. This inverse breathing device provides a potential system to support long-term cell function in the clinically attractive subcutaneous site.

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Section: Resultssupporting

confidence: 90%

An inverse-breathing encapsulation system for cell delivery

et al. 2021

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“…Diabetes correction was observed up to 12 weeks in a diabetic mouse model, providing a proof‐of‐concept for the application of this intricate cell‐based technique. [ 138 ] It would thus be interesting to explore alternative, biodegradable materials for the production of the flexible reinforcement structure, while retaining the attractive mechanical properties that allow for device retrieval.…”

Section: Low Material‐based Te Strategies Aiming Tissue Healingmentioning

confidence: 99%

Minimalist Tissue Engineering Approaches Using Low Material‐Based Bioengineered Systems

Correia

Bjørge

Nadine

et al. 2021

Adv Healthcare Materials

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From an “over‐engineering” era in which biomaterials played a central role, now it is observed to the emergence of “developmental” tissue engineering (TE) strategies which rely on an integrative cell‐material perspective that paves the way for cell self‐organization. The current challenge is to engineer the microenvironment without hampering the spontaneous collective arrangement ability of cells, while simultaneously providing biochemical, geometrical, and biophysical cues that positively influence tissue healing. These efforts have resulted in the development of low‐material based TE strategies focused on minimizing the amount of biomaterial provided to the living key players of the regenerative process. Through a “minimalist‐engineering” approach, the main idea is to fine‐tune the spatial balance occupied by the inanimate region of the regenerative niche toward maximum actuation of the key living components during the healing process.

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“…Mice models received islet-containing constructs comprising the release of trophic/proangiogenic molecules from encapsulating biomaterials [85], the incorporation of immunomodulatory molecules in materials [86], as well as the cotransplantation of islets with other cell types [87]. Tailoring the device topography [88] and conformational design (e.g., donut-shaped [89], fiber-shaped [90], or 3D macroporous structures [91]), biomaterial chemistry, and mechanical properties, as well as the inclusion of extracellular matrix proteins in the encapsulating matrix [85,88,92] have been explored as roadways to improve/extend transplanted islet function.…”

Section: Approaches Combining Biomaterials and Cellsmentioning

confidence: 99%

Engineering Strategies for Allogeneic Solid Tissue Acceptance

Sousa

Mano

Oliveira

2021

Trends in Molecular Medicine

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Systemic immunosuppressants have allowed the transplantation of life-saving organs. However, they cause deleterious effects and long-term graft failure. Strategies promoting allogeneic graft acceptance and the maintenance of immunological competence have been proposed.Cell-based tolerance-inducing strategies that preserve immune competence have already extended human allograft acceptance, although toxic side effects or difficult reproduction of observed effects in humans have counteracted their clinical translation.Localized tolerance/immunosuppression mediated through bioengineered setups comprising immunomodulatory biomaterials and/or tissue engineeringinspired tools already achieved allograft acceptance in murine models and are game changing in the field. Such advances have contributed to unveiling the complex interplay of immune cells and allogeneic transplants.

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Interconnected Toroidal Hydrogels for Islet Encapsulation

Abstract: COMMUNICATION 1900423 (1 of 8)

Cited by 42 publications

References 37 publications

An inverse-breathing encapsulation system for cell delivery

An inverse-breathing encapsulation system for cell delivery

Minimalist Tissue Engineering Approaches Using Low Material‐Based Bioengineered Systems

Engineering Strategies for Allogeneic Solid Tissue Acceptance

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