Photoluminescence ͑PL͒ from GaInSb/AlInSb type I multi-quantum-wells, grown on GaAs, has been investigated as a function of strain in the quantum wells. Luminescence, between 3 and 4 m, was observed for all samples, with good agreement between the measured and calculated peak emission energies. Analysis of the temperature dependence of the luminescence suggests that population of excited quantum well hole subbands occurs at high temperature, leading to a reduction in the PL signal. Room temperature luminescence was obtained from a sample with ϳ0.8% strain in the quantum wells. Preliminary results from laser diodes fabricated from companion wafers indicate lasing up to 220 K. © 2008 American Institute of Physics. ͓DOI: 10.1063/1.2990224͔Continuing interest in the development of III-V alloys for use in mid-infrared ͑3-5 m͒ light sources and detectors is driven by the extensive range of potential applications in this spectral region, including environmental gas monitoring, noninvasive medical diagnosis, tunable infrared spectroscopy, and free space optical communications.1 Over the last couple of years, there has been significant progress in laser performance leading to, for example, recent reports of room temperature cw lasing at 3.8 m from quantum cascade lasers, 2 at 3.75 m from interband cascade lasers, 3 and at 3.36 m from compressively strained type 1 quantum wells ͑QWs͒. 4 We have also previously reported lasing from simpler double heterostructures 5 and type I multi-quantumwell ͑MQW͒ lasers based on the GaInSb/AlGaInSb/AlInSb material system. 6 This material system has the potential advantages of being able to achieve band offsets suitable for electronic confinement and also provide sufficiently high compressive strain for lower threshold laser operation, 7 and we recently reported on the successful realization of midinfrared coherent emission from MQW diode lasers using this material system grown by molecular beam epitaxy ͑MBE͒ on GaAs substrates.6 However, to realize the advantages of this material system, a greater understanding of the optical properties of these MQWs is required, and in this paper we analyze the photoluminescence ͑PL͒ from the GaInSb MQWs in the active region, with the aim of investigating the effect of strain in the QWs on their optical properties. We also report preliminary measurements made on laser diodes fabricated from companion wafers and the materials parameters and theoretical model used to describe the PL results will be later applied to fully understand the properties of these lasers.