Interactions of the lepidotrichial matrix components during tail fin regeneration in teleosts

Santamaría, Jesús A.; Marí‐Beffa, Manuel; Becerra, José

doi:10.1111/j.1432-0436.1992.tb00662.x

Cited by 40 publications

(35 citation statements)

References 19 publications

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“…Analyzing the type of collagen present in regenerating lepidotrichia and actinotrichia was beyond the scope of the present study. As a matter of fact, not even the type of collagen present in normal actinotrichia and lepidotrichia is yet known (SANTAMARIA et al, 1992). We have reported that the mean diameter of collagen fibrils in lepidotrichia was within the range of that of Type-II collagen fibrils in cartilages obtained from the same specimens, whilst the observations reported in the same article suggested that actinotrichia may be composed of a different type of collagen, unique to this structure (MONTES et al, 1982).…”

Section: Discussionmentioning

confidence: 82%

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Regeneration of Fin Rays in Teleosts: A Histochemical, Radioautographic, and Ultrastructural Study.

Becerra

Junqueira

Bechara

et al. 1996

Archives of Histology and Cytology

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Section: Discussionmentioning

confidence: 82%

“…However, collagen typing by means of fibril diameter morphometry is likely to remain a controversial issue (KEENE et al, 1987). In addition, immunocytochemistry using antibodies raised against mammalian Type-I and Type-II collagens produced irregular results in tailfin rays of teleosts (SANTAMARiA et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

Regeneration of Fin Rays in Teleosts: A Histochemical, Radioautographic, and Ultrastructural Study.

Becerra

Junqueira

Bechara

et al. 1996

Archives of Histology and Cytology

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“…Histological and immunologic analyses revealed that type II collagen (Montes et al, 1982) and glycosaminoglycans were components of the regenerating bony fin ray (Santamaria and Becerra, 1991;Santamaria et al, 1992). We found several typical collagens, such as type I, II, V, VIII, X, XI and XII collagen, in our ESTs.…”

Section: Extracellular Matrix Expressed In Regenerating Bony Fin Raymentioning

confidence: 81%

Large-scale analysis of the genes involved in fin regeneration and blastema formation in the medaka, Oryzias latipes

Katogi

Nakatani

Shin-I

et al. 2004

Mechanisms of Development

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Medaka is an attractive model to study epimorphic regeneration. The fins have remarkable regenerative capacity and are replaced about 14 days after amputation. The formation of blastema, a mass of undifferentiated cells, is essential for regeneration; however, the molecular mechanisms are incompletely defined. To identify the genes required for fin regeneration, especially for blastema formation, we constructed cDNA libraries from fin regenerates at 3 days postamputation and 10 days postamputation. A total of 16,866 expression sequence tags (ESTs) were sequenced and subjected to BLASTX analysis. The result revealed that about 60% of them showed strong matches to previously identified proteins, and major signaling molecules related to development, including FGF, BMP, Wnt, Notch/Delta, and Ephrin/Eph signaling pathways were isolated. To identify novel genes that showed specific expression during fin regeneration, cDNA microarray was generated based on 2900 independent ESTs from each library which had no sequence similarity to known proteins. We obtained 6 candidate genes associated with blastema formation by gene expression pattern screening in competitive hybridization analyses and in situ hybridization. Olrfe16d23 and olrfe14k04 were expressed only in early regenerating stages when blastema formation was induced. The expression of olrf5n23, which encodes a novel signal peptide, was detected in wound epidermis throughout regeneration. Olrfe23l22, olrfe20n22, and olrfe24i02 were expressed notably in the blastema region. Our study has thus identified the gene expression profiles and some novel candidate genes to facilitate elucidation of the molecular mechanisms of fin regeneration.

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“…The cell cycle speeds up, from a median G2 length of >6 h during blastema formation to only 1 h during outgrowth (Nechiporuk and Keating 2002), and the fin begins to rapidly grow back. Blastemal cells differentiate into scleroblasts, which begin to secrete the matrix that will form the new bones, the lepidotrichia (Geraudie and Singer 1992;Santamaria et al 1992;Becerra et al 1996;Mari-Beffa et al 1996). Both of the usual suspects, Wnt/␤-catenin signaling and FGF signaling, are still active and important for the outgrowth phase of fin regeneration; both pathways are required for expression of shh, which becomes an important player during this time (Laforest et al 1998;Poss et al 2000;Stoick-Cooper et al 2007).…”

Section: Regenerative Outgrowthmentioning

confidence: 99%

Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine

Stoick-Cooper¹,

Moon²,

Weidinger³

2007

Genes Dev.

275

278

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While all animals have evolved strategies to respond to injury and disease, their ability to functionally recover from loss of or damage to organs or appendages varies widely damage to skeletal muscle, but, unlike amphibians and fish, they fail to regenerate heart, lens, retina, or appendages. The relatively young field of regenerative medicine strives to develop therapies aimed at improving regenerative processes in humans and is predicated on >40 years of success with bone marrow transplants. Further progress will be accelerated by implementing knowledge about the molecular mechanisms that regulate regenerative processes in model organisms that naturally possess the ability to regenerate organs and/or appendages. In this review we summarize the current knowledge about the signaling pathways that regulate regeneration of amphibian and fish appendages, fish heart, and mammalian liver and skeletal muscle. While the cellular mechanisms and the cell types involved in regeneration of these systems vary widely, it is evident that shared signals are involved in tissue regeneration. Signals provided by the immune system appear to act as triggers of many regenerative processes. Subsequently, pathways that are best known for their importance in regulating embryonic development, in particular fibroblast growth factor (FGF) and Wnt/␤-catenin signaling (as well as others), are required for progenitor cell formation or activation and for cell proliferation and specification leading to tissue regrowth. Experimental activation of these pathways or interference with signals that inhibit regenerative processes can augment or even trigger regeneration in certain contexts.

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Interactions of the lepidotrichial matrix components during tail fin regeneration in teleosts

Cited by 40 publications

References 19 publications

Regeneration of Fin Rays in Teleosts: A Histochemical, Radioautographic, and Ultrastructural Study.

Regeneration of Fin Rays in Teleosts: A Histochemical, Radioautographic, and Ultrastructural Study.

Large-scale analysis of the genes involved in fin regeneration and blastema formation in the medaka, Oryzias latipes

Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine

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