Interactions of the human telomeric DNA with terbium–amino acid complexes

Xu, Haixia; Zhang, Haiyuan; Qu, Xiaogang

doi:10.1016/j.jinorgbio.2006.05.015

Cited by 41 publications

(36 citation statements)

References 20 publications

(30 reference statements)

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“…2) by microscopy. These results are consistent with the previous studies [25][26][27][28]. Apoptosis as a process intimately linked to the cell cycle [33].…”

Section: Discussionsupporting

confidence: 93%

“…Some reports showed that La induces apoptosis in certain cancer cells [27]. Xu's [28] research indicated that terbium-amino acid complexes can bind to the human telomeric DNA and have shown different features on DNA stability, binding stoichiometry, and sequence-dependent fluorescence enhancement. La has been regarded as calcium ion (Ca 2+ ) antagonist because of its similarity in coordination chemistry to Ca 2+ [29].…”

Section: Discussionmentioning

confidence: 99%

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Telomerase-Mediated Apoptosis of Chicken Lymphoblastoid Tumor Cell Line by Lanthanum Chloride

Zhang

Wang

et al. 2011

Biol Trace Elem Res

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To investigate the biological effects of lanthanum on chicken lymphoid tumors, cultures of the MDCC-MSB1 chicken lymphoblastoid cell line were treated with 2.5 mM lanthanum chloride for 2 days at 12-h intervals. The apoptotic cells were detected using the TdT-mediated dUTP nick end labeling assay and flow cytometer analysis. The telomerase activity and the chTERT mRNA expression levels of the MDCC-MSB1 cells were examined. The results showed that MDCC-MSB1 cell apoptosis occurred after incubation for 12 to 48 h induced by 2.5 mM LaCl(3). Consistent with the apoptosis results, telomerase activities in LaCl(3)-treated cells significantly decreased (P < 0.05) compared with 0 h group. Furthermore, the transcription of chTERT gene in MDCC-MSB1 cell was significantly inhibited in LaCl(3) treatment group (P < 0.05). These results suggest that the decrease of the chTERT transcription and telomerase activity play an important role in the La-induced apoptosis in chicken lymphoid tumor.

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“…2) by microscopy. These results are consistent with the previous studies [25][26][27][28]. Apoptosis as a process intimately linked to the cell cycle [33].…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Telomerase-Mediated Apoptosis of Chicken Lymphoblastoid Tumor Cell Line by Lanthanum Chloride

Zhang

Wang

et al. 2011

Biol Trace Elem Res

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“…More recently, Mao and co-workers have indicated that i-motif structure may interfere with RNA transcription [21]. But until now a few of small molecules that interact with i-motif DNA have been reported [22,23].…”

Section: Introductionmentioning

confidence: 99%

The interactions of phenanthroline compounds with DNAs: Preferential binding to telomeric quadruplex over duplex

Wang

Chen

et al. 2013

International Journal of Biological Macromolecules

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“…[13] It has been reported that denaturation of the Gquadruplex can be monitored by the hypochromicity change at 295 nm. From the melting profiles in Figure 2A, the chiral selectivity on inducing G-quadruplex formation of human telomeric DNA by the [Ni 2 L 3 ]…”

Section: Resultsmentioning

confidence: 99%

Chiral Metallo–Supramolecular Complexes Selectively Induce Human Telomeric G‐Quadruplex Formation under Salt‐Deficient Conditions

Zhao

Geng

Feng

et al. 2011

Chemistry A European J

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Chiral molecular recognition of human telomeric DNA is important for rational drug design and developing structural probes of G-quadruplexes. Here we report that a chiral supramolecular complex can selectively induce human telomeric G-quadruplex formation and discriminate different G-quadruplex sequences under salt-deficient conditions studied by circular dichroism (CD), UV meltings, stopped-flow spectroscopy, fluorescence resonance energy transfer, enzyme cleavage, and gel electrophoresis. P-enantiomer induced G-quadruplex formation is fast and does not require a large excess of P enantiomer. More importantly, this chiral compound induces loop sequence-dependent G-quadruplex formation.

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Interactions of the human telomeric DNA with terbium–amino acid complexes

Cited by 41 publications

References 20 publications

Telomerase-Mediated Apoptosis of Chicken Lymphoblastoid Tumor Cell Line by Lanthanum Chloride

Telomerase-Mediated Apoptosis of Chicken Lymphoblastoid Tumor Cell Line by Lanthanum Chloride

The interactions of phenanthroline compounds with DNAs: Preferential binding to telomeric quadruplex over duplex

Chiral Metallo–Supramolecular Complexes Selectively Induce Human Telomeric G‐Quadruplex Formation under Salt‐Deficient Conditions

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