Interactions of testosterone and all-trans retinoic acid in regulation of androgen receptor expression in rat lacrimal gland

Ubels, John L.; Veenstra, E.D.; Ditlev, J.A.; Ingersoll, Kyle E.

doi:10.1016/j.exer.2003.07.006

Cited by 11 publications

(5 citation statements)

References 21 publications

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“…324 -331 In effect, the retinoic acid derivatives promote MGD and evaporative dry eye. 330,332,333 Major mechanisms involved in the action of retinoic acid include the suppression of androgen receptor mRNA and protein 334,335 and the inhibition of retinol dehydrogenase-4, which leads to a decrease in the local production of dihydrotestosterone. 336 Understanding the influence of retinoic acid on the meibomian gland is very important, given that this compound is the key ingredient of many antiaging cosmetics for use around the eye, and as people age they become more susceptible to the development of dry eye.…”

Section: Effect Of All-trans Retinoic Acid On the Meibomian Glandmentioning

confidence: 99%

The International Workshop on Meibomian Gland Dysfunction: Report of the Subcommittee on Anatomy, Physiology, and Pathophysiology of the Meibomian Gland

Knop

Millar

et al. 2011

Invest. Ophthalmol. Vis. Sci.

853

968

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Section: Effect Of All-trans Retinoic Acid On the Meibomian Glandmentioning

confidence: 99%

The International Workshop on Meibomian Gland Dysfunction: Report of the Subcommittee on Anatomy, Physiology, and Pathophysiology of the Meibomian Gland

Knop

Millar

et al. 2011

Invest. Ophthalmol. Vis. Sci.

853

968

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“…Therefore, we propose that androgens and retinoids regulate spermatogenesis in a complementary manner to guarantee efficient sperm production in zebrafish. Although an androgen/retinoid interplay promoting spermatogonia differentiation is a new proposal, interactions between androgen and RA signaling have been demonstrated in other tissues/cell types (Li et al, 2002;Munetsuna et al, 2009;Ubels et al, 2003). In contrast to mammalian models, where preventing either androgen or retinoid signaling completely blocked spermatogenesis, removing one of these pathways in zebrafish still allows (some) sperm production to occur, albeit in a compromised manner.…”

Section: Androgens and Retinoids Jointly Promote Spermatogenesismentioning

confidence: 99%

Endocrine and local signaling interact to regulate spermatogenesis in zebrafish: Follicle-stimulating hormone, retinoic acid and androgens

et al. 2019

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Retinoic acid (RA) is critical for mammalian spermatogonia differentiation, and stimulates Stra8 expression, a gene required for meiosis. Certain fish species, including zebrafish, have lost the stra8 gene. While RA still seems important for spermatogenesis in fish, it is not known which stage(s) respond to RA or if its effects are integrated into the endocrine regulation of spermatogenesis. In zebrafish, RA promoted spermatogonia differentiation, supported androgen-stimulated meiosis and reduced spermatocyte and spermatid apoptosis. Follicle-stimulating hormone (Fsh) stimulated RA production. Expressing a dominant-negative RA receptor variant in germ cells clearly disturbed spermatogenesis but meiosis and spermiogenesis still took place although sperm quality was low in 6 months-old adults. This condition also activated Leydig cells. Three months later, spermatogenesis apparently had recovered, but doubling of testis weight demonstrated hypertrophy, apoptosis/DNA damage among spermatids was high and sperm quality remained low. We conclude that RA signaling is important for zebrafish spermatogenesis but is not of critical relevance. Since Fsh stimulates androgen and RA production, germ cell-mediated, RA-dependent reduction of Leydig cell activity may form a hitherto unknown intratesticular negative feedback loop.

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“…These effects appear to be mediated through receptor-dependent and –independent actions (Nelson and others 2006; Tsukada and others 2000) and alterations in gene expression (Nelson and others 2008). In addition, RA may suppress androgen receptors (Ubels and others 2003; Ubels and others 2002) and inhibit retinol dehydrogenase-4 in sebaceous glands (Karlsson and others 2003), which would diminish the local, intracrine production of dihydrotestosterone (DHT). Of interest, specific deletion of scd-1 in the mouse skin causes a robust elevation of retinol, RA and RA-induced genes in the skin (Flowers and others 2011).…”

Section: Anti-aging Treatment- Potential Influence On Mgd and Dry Eyementioning

confidence: 99%

Aging and dry eye disease

Ding

Sullivan

2012

Experimental Gerontology

134

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Dry eye disease is a prevalent eye disorder that in particular affects the elderly population. One of the major causes of dry eye, meibomian gland dysfunction (MGD), shows increased prevalence with aging. MGD is caused by hyperkeratinization of the ductal epithelium of meibomian gland and reduced quantity and/or quality of meibum, the holocrine product that stabilizes and prevents the evaporation of the tear film. Of note, retinoids which are used in current anti-aging cosmetics may promote the development of MGD and dry eye disease. In this review, we will discuss the possible mechanisms of age-related MGD.

show abstract

Interactions of testosterone and all-trans retinoic acid in regulation of androgen receptor expression in rat lacrimal gland

Cited by 11 publications

References 21 publications

The International Workshop on Meibomian Gland Dysfunction: Report of the Subcommittee on Anatomy, Physiology, and Pathophysiology of the Meibomian Gland

The International Workshop on Meibomian Gland Dysfunction: Report of the Subcommittee on Anatomy, Physiology, and Pathophysiology of the Meibomian Gland

Endocrine and local signaling interact to regulate spermatogenesis in zebrafish: Follicle-stimulating hormone, retinoic acid and androgens

Aging and dry eye disease

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