Interactions of Renin–angiotensin System Gene Polymorphisms and Antihypertensive Effect of Benazepril in Chinese Population

Abstract

Gender-specific gene-gene interactions of the AGT, AGTR1 and ACE2 genes were associated with individual variation of response to benazepril. Further studies are needed to confirm this finding.

Epistatic interaction between common AGT G(− 6)A (rs5051) and AGTR1 A1166C (rs5186) variants contributes to variation in kidney size at birth

“…An important question remains as to whether the statistical epistasis (viewed as non-additivity of individual gene effects at the population level) between AGT and AGTR1 does actually imply a biological phenomenon: that is, a biomolecular interaction that affects the function of biochemical, metabolic or physiological systems (Moore and Williams, 2005). Although interaction between AGT and AGTR1 genes has been reported with respect to pulmonary complications (Salnikova et al, 2013), variation of response to antihypertensive drug (Chen et al, 2011), risk of myocardial infarction (Araújo et al, 2005), atrial fibrillation (Tsai et al, 2008), and end-stage renal disease (Su et al, 2014), other studies have failed to demonstrate this interaction (Tsai et al, 2007;Zhou et al, 2012).…”

The Gene-Gene Interaction of INSIG-SCAP-SREBP Pathway on the Risk of Obesity in Chinese Children

“…The INSIG-SCAP-SREBP pathway plays a crucial role in feedback regulating lipid synthesis. Components of the pathway may not serve as independent factors, because one component usually needs to contact with others in the pathway to complete some biological function [37]. SREBP2 is important to sterol regulation and it is synthesized and located on the endoplasmic reticulum (ER) membrane in their precursor form [38].…”